A5024524782- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Head and Neck Cancer Studies
- Neural dynamics and brain function
- Neurological Disease Mechanisms and Treatments
- Fetal and Pediatric Neurological Disorders
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Nicotinic Acetylcholine Receptors Study
- Radiomics and Machine Learning in Medical Imaging
- Smoking Behavior and Cessation
- Mental Health Research Topics
- Cerebrovascular and genetic disorders
- Neuroscience and Neuropharmacology Research
- Health, Environment, Cognitive Aging
- Heart Rate Variability and Autonomic Control
Second Affiliated Hospital of Zhejiang University
2016-2025
Wenzhou Medical University
2020-2025
First Affiliated Hospital of Wenzhou Medical University
2020-2025
Zhejiang University
2014-2024
University of Hong Kong
2023-2024
Harbin Institute of Technology
2021-2024
Shenzhen Institute of Information Technology
2024
First Affiliated Hospital of Guangzhou Medical University
2022-2024
State Key Laboratory of Respiratory Disease
2022-2024
Guangzhou Medical University
2022-2024
Neuro-inspired vision systems hold great promise to address the growing demands of mass data processing for edge computing, a distributed framework that brings computation and storage closer sources data. In addition capability static image sensing processing, hardware implementation neuro-inspired system also requires fulfilment detecting recognizing moving targets. Here, we demonstrated optical sensor based on two-dimensional NbS2/MoS2 hybrid films, which featured remarkable photo-induced...
Abstract Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel (CSVD) the most common pathogenesis We hypothesize that AD and CSVD could be associated glymphatic dysfunction, contributing to cognitive impairment. Method Participants completed amyloid PET, diffusion tensor imaging (DTI), T2 fluid-attenuated inversion-recovery (FLAIR) sequences were included from Disease Neuroimaging Initiative (ADNI)....
The progression of Parkinson's disease (PD) seems to vary according the stage, which greatly influences management PD patients. However, underlying mechanism in remains unclear. This study was designed explore progressive pattern iron accumulation at different stages Sixty right-handed patients and 40 normal controls were recruited. According 45 with Hoehn-Yahr stage ≤ 2.5 15 ≥ 3 grouped into early-stage (EPD) late-stage (LPD) groups, respectively. content cardinal subcortical nuclei...
Abstract Increasing evidence suggests that Parkinson’s disease (PD) exhibits disparate spatial and temporal patterns of progression. Here we used a machine-learning technique—Subtype Stage Inference (SuStaIn) — to uncover PD subtypes with distinct trajectories clinical neurodegeneration events. We enrolled 228 patients 119 healthy controls comprehensive assessments olfactory, autonomic, cognitive, sleep, emotional function. The integrity substantia nigra (SN), locus coeruleus (LC), amygdala,...
Two-dimensional (2D) layered semiconductors with nonlinear optical (NLO) properties hold great promise to address the growing demand of multifunction integration in electronic-photonic integrated circuits (EPICs). However, co-design 2D NLO for on-chip telecommunication is limited by their essential shortcomings terms unsatisfactory optoelectronic properties, odd-even layer-dependent activity and low susceptibility telecom band. Here we report synthesis SnP2Se6, a van der Waals semiconductor...
Arterial pulsation has been suggested as a key driver of paravascular cerebrospinal fluid flow, which is the foundation glymphatic clearance. However, whether intracranial arterial pulsatility associated with markers in humans not yet studied. Seventy-three community participants were enrolled study. 4D phase-contrast magnetic resonance imaging (MRI) was used to quantify hemodynamic parameters including flow index (PIflow) and area (PIarea) from 13 major intracerebral segments. Three...
ABSTRACT Background Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality patients' life. Although disturbances in some related brain networks have been reported, pathophysiology depression PD still unclear. Here, we aim to investigate whole‐brain functional connectivity patterns depressed patients. Methods We recruited 17 patients diagnosed with major depressive disorder, without depression, healthy control subjects....
Because the roles of striatal-thalamo-cortical and cerebello-thalamo-cortical circuits in heterogeneous motor impairments Parkinson's disease (PD) are becoming recognized, this study was designed to investigate relationships between regional iron cardinal subcortical nuclei these different impairments.Sixty-two PD patients 40 normal subjects were included accepted for Enhanced T2 -Star Weighted Angiography Scanning (3.0T). According Unified Disease Rating Scale, divided into tremor-dominant...
In the era of intensity-modulated radiotherapy (IMRT), role neoadjuvant chemotherapy (NAC) for locoregionally advanced nasopharyngeal carcinoma (NPC) is under-evaluated. The aim this study was to compare efficacy NAC plus IMRT and concurrent chemoradiotherapy (CCRT) adjuvant (AC) on NPC. Between January 2004 December 2008, 240 cases NPC confirmed by pathologic assessment in Sun Yat-sen University Cancer Center were reviewed. Of patients, 117 received followed IMRT, 123 treated with CCRT AC....
Assessing glymphatic function using in-vivo imaging method is of great value for understanding its contribution to major brain diseases. In the present study, we aim validate association between a variety risk factors and potential index function—Diffusion Tensor Image Analysis Along Perivascular Space (ALPS index). We enrolled 142 subjects from communities performed multi-modality magnetic resonance scans. The ALPS was calculated diffusion tensor data, associations with demographic factors,...
Understanding the pathophysiology of white matter hyperintensity (WMH) is necessary to reduce its harmfulness. Dilated perivascular space (PVS) had been found related WMH. In present study, we aimed examine topological connections between WMH and PVS, investigate whether increased interstitial fluid mediates correlation PVS volumes. One hundred thirty-six healthy elder subjects were retrospectively included from a prospectively collected community cohort. Sub-millimeter T2 weighted FLAIR...
Glymphatic dysfunction may contribute to the accumulation of Alzheimer's disease (AD) pathologies. Conversely, AD pathologic change might also cause neuroinflammation and aggravate glymphatic dysfunction, forming a loop that accelerates progression. In vivo validations are needed confirm their relationships.In this study, we included 144 cognitively normal participants with pathological biomarker data (baseline CSF Aβ1-42, T-Tau, P-Tau181; plasma P-Tau181 at baseline least one follow-up)...
Background: Obesity is considered a risk factor for the development of several neurodegenerative diseases, including Parkinson's disease (PD). Recent studies have revealed that glymphatic function compromised in PD patients. This study aims to investigate impact different body mass index (BMI) statuses on system patients using diffusion tensor image analysis along perivascular space (DTI-ALPS) method.
Abstract Background and purpose Glymphatic dysfunction may play a significant role in the development of neurodegenerative diseases. We aimed to evaluate association between glymphatic risk malignant event/clinical milestones Parkinson disease (PD). Methods This study included 236 patients from August 2014 December 2020. Diffusion tensor imaging analysis along perivascular space (DTI‐ALPS) index was calculated as an approximate measure function. The primary outcomes were four clinical...
As a complex mental process, creativity requires the coordination of multiple brain regions. Previous pathological research on figural has indicated that there is mechanism by which left side inhibits activities right during creative thinking, but this not been directly demonstrated. In study, we used functional magnetic resonance imaging (fMRI) to demonstrate existence inhibitory in young adults (15 women, 11 men, mean age: 22 years) were artists. By making comparisons between activity and...
Abstract Organic–inorganic hybrid perovskites have realized a high power conversion efficiency (PCE) in both n–i–p and p–i–n device configurations. However, since the structure exempts sophisticated processing of charge‐transporting layers, it seems to possess better potential for practical applications than one. Currently, inorganic NiO x is most prevailing hole‐transporting layer (HTL) used perovskite solar cells. Nevertheless, defects might exist on its surface influence charge...
Deep medullary veins (DMVs) participate in the drainage of surrounding white matter. In cerebral small vessel disease (CSVD), disrupted DMVs were often observed together with damaged matter, but phenomenon lacked validation and explanation. We hypothesized that venous disruption might cause matter damage through increased interstitial fluid resulting from hemodynamic alteration, we designed a comprehensive multi-modality MRI study to testify our hypothesis. Susceptibility-weighted imaging...
Purpose This study aimed to develop and validate a radiomics model based on whole‐brain white matter clinical features predict the progression of Parkinson disease (PD). Methods PD patient data from Parkinson's Progress Markers Initiative (PPMI) database was evaluated. Seventy‐two patients with progression, as measured by Hoehn‐Yahr Scale (HYS) (stage 1‐5), 72 stable were matched sex, age, category HYS included in current study. Each individual’s T 1 ‐weighted MRI scans at baseline timepoint...