A5028289735- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Corneal Surgery and Treatments
- Periodontal Regeneration and Treatments
- Knee injuries and reconstruction techniques
- Ocular Surface and Contact Lens
- Mesenchymal stem cell research
- Corneal surgery and disorders
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Retinal Diseases and Treatments
- Nanoparticles: synthesis and applications
- Reproductive Biology and Fertility
- Wound Healing and Treatments
- Wnt/β-catenin signaling in development and cancer
- Retinal Development and Disorders
- Tissue Engineering and Regenerative Medicine
- Connexins and lens biology
- Gestational Diabetes Research and Management
- Smart Grid and Power Systems
- Solidification and crystal growth phenomena
- Proteoglycans and glycosaminoglycans research
- Air Quality and Health Impacts
- Advanced Decision-Making Techniques
- Energy Load and Power Forecasting
Sun Yat-sen University
2016-2025
State Grid Corporation of China (China)
2013-2024
Chengdu Fifth People's Hospital
2023-2024
Jinan University
2024
PowerChina (China)
2023-2024
Chengdu University of Traditional Chinese Medicine
2023-2024
Hangzhou First People's Hospital
2024
Fanjingshan National Nature Reserve
2024
Health Commission of Anhui Province
2023
China Electronics Technology Group Corporation
2023
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role osteoclast-initiated subchondral bone remodeling in sensory innervation for OA pain. We show that osteoclasts secrete netrin-1 to induce nerve axonal growth bone. Reduction osteoclast formation by knockout receptor activator nuclear factor kappa-B ligand (Rankl) osteocytes inhibited nerves into bone, dorsal root ganglion neuron hyperexcitability,...
Unlike braided fabrics, knitted scaffolds have been proven to favor deposition of collagenous connective tissue matrix, which is crucial for tendon/ligament reconstruction. But cell seeding such often requires a gel system, unstable in dynamic situation, especially the knee joint. This study developed novel, biodegradable nano-microfibrous polymer scaffold by electrospinning PLGA nanofibers onto order provide large biomimetic surface attachment. Porcine bone marrow stromal cells were seeded...
Significance Retinal damage and resulting irreversible vision loss are feared complications of rapid substantially elevated intraocular pressure (IOP) in acute glaucoma. An inflammatory response to retinal ischemia/reperfusion injury involving Toll-like receptor 4 (TLR4) IL-1β has been implicated disease pathogenesis; however, the underlying mechanisms remain incompletely understood. This study demonstrates critical role caspase-8 IOP-induced cell death rodent models TLR4 signaling, mediated...
Abstract Carbon nanotubes (CNTs) hold promise in manufacturing, environmental, and biomedical applications, as well food agricultural industries. Previous observations have shown that CNTs antimicrobial activity; however, the impact of to human gut microbes has not been investigated. Here, antibacterial activity against commonly encountered digestion system— L. acidophilus , B. adolescentis E. coli faecalis S. aureus —are evaluated. The bacteria studied include pathogenic non‐pathogenic,...
Abstract Epigenetic alterations and metabolic dysfunction are two hallmarks of aging. However, the mechanism how their interaction regulates aging, particularly in mammals, remains largely unknown. Here we show ELOVL fatty acid elongase 2 (Elovl2), a gene whose epigenetic most highly correlated with age prediction, contributes to aging by regulating lipid metabolism. We applied artificial intelligence predict protein structure ELOVL2 its substrate. Impaired Elovl2 function disturbs synthesis...
The objectives of this study were to evaluate the morphology and biomechanical function Achilles tendons regenerated using knitted poly-lactide-co-glycolide (PLGA) loaded with bone marrow stromal cells (bMSCs). animal model used was that an adult female New Zealand White rabbit a 10-mm gap defect tendon. In group I, 19 hind legs created defects treated allogeneic bMSCs seeded on PLGA scaffold. II, tendon in repaired scaffold alone, III, 6 as normal control. tendon-implant constructs groups I...
Abstract Multipotent mesenchymal stem cells (MSC) are reported to be immunoprivileged as well immunosuppressive. Hence, they ideal candidates for allogeneic transplantation induce regeneration of diseased tissues and organs. However, it is not known whether MSC would retain their immunomodulatory properties after differentiating into the local cell types site. This study sought investigate this question with a novel New Zealand White rabbit osteogenesis model. Results showed that osteogenic...
Exposure to nanoparticles has presented potential risks human cardiorespiratory systems. Pulmonary retention and extrapulmonary redistribution of inhaled have been considered be important contributing factors diseases. In the present work, 22-nm 59Fe2O3 (radioactive isotope 59Fe-labeled ferric oxide nanoparticles) were intratracheally instilled into male Sprague-Dawley rats at a dose 4 mg/rat. Extrapulmonary distribution in organs its metabolism lung, blood, urine, feces measured for 50 days...
Abstract Human embryonic stem cells (hESCs) are ideal seed for tissue regeneration, but no research has yet been reported concerning their potential tendon regeneration. This study investigated the strategy and efficacy of using hESCs regeneration as well mechanism involved. were first induced to differentiate into mesenchymal (MSCs), which had three lineages positive MSC surface markers. hESC-derived MSCs (hESC–MSCs) regenerated tissues in both an vitro engineering model vivo ectopic model,...