A5100353748- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Genetic Mapping and Diversity in Plants and Animals
- RNA Research and Splicing
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- Plant Reproductive Biology
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Wheat and Barley Genetics and Pathology
- Genetics and Plant Breeding
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Glioma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Legume Nitrogen Fixing Symbiosis
- Autophagy in Disease and Therapy
- Plant Disease Resistance and Genetics
- Cryptography and Data Security
Sun Yat-sen University
2012-2025
Nanjing Drum Tower Hospital
2023-2025
University of Chinese Academy of Sciences
2008-2025
Chinese Academy of Sciences
2016-2025
Central South University
2021-2025
Institute of Applied Ecology
2025
Nanjing Medical University
2013-2025
Hospital of Hebei Province
2025
Nanjing University
2022-2025
Jiangxi Agricultural University
2023-2024
Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests involvement epigenetic pathways, mechanisms remains unclear. Two studies now show that altered paternal diet affects level mouse sperm. Chen et al. injected transfer RNA (tRNA) fragments from males had been kept on a high-fat into normal oocytes. The progeny displayed disorders and concomitant alteration genes pathways. Sharma observed...
Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved colorectal carcinogenesis. identity and functional capacity of adenoma- or carcinoma-related microbe(s), however, have not been surveyed comprehensive manner. Here we perform metagenome-wide association study (MGWAS) on stools advanced adenoma carcinoma patients healthy subjects, revealing microbial genes, strains...
DNA methylation plays an important role in biological processes human health and disease. Recent technological advances allow unbiased whole-genome (methylome) analysis to be carried out on cells. Using bisulfite sequencing at 24.7-fold coverage (12.3-fold per strand), we report a comprehensive (92.62%) methylome of the unique sequences peripheral blood mononuclear cells (PBMC) from same Asian individual whose genome was deciphered YH project. PBMC constitute source for clinical tests...
DNA methylation plays important biological roles in plants and animals. To examine the rice genomic landscape assess its functional significance, we generated single-base resolution methylome maps for Asian cultivated Oryza sativa ssp. japonica, indica their wild relatives, rufipogon nivara.The overall level of genomes is four times higher than that Arabidopsis. Consistent with results reported Arabidopsis, promoters represses gene expression while gene-body generally appears to be...
Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an estimation the relative contribution genetic shared nonshared environmental factors to phenotypic variability. Using DNA methylation profiling ∼20,000 CpG sites as a phenotype, we have examined discordance levels in three neonatal tissues from 22 MZ 12 DZ twin pairs. exhibit wide range within-pair differences at birth, but show generally lower than Within-pair was lowest islands all increased function distance...
Abstract Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are very limited and the underlying mechanisms poorly understood. We report that bone-borne TGF-β induces acetylation of transcription factor KLF5 in PCa metastases, acetylated (Ac-KLF5) causes osteoclastogenesis metastatic lesions by activating CXCR4, leads to IL-11 secretion, stimulating SHH/IL-6 paracrine signaling. While essential maintaining mesenchymal phenotype tumorigenicity, Ac-KLF5 also...
Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution human genetic architecture and diversity. We present such study 50 species spanning 38 genera 14 families, including 27 first reported here, with many from previously less well represented groups, New World monkeys Strepsirrhini. Our analyses reveal heterogeneous rates genomic rearrangement gene across lineages. Thousands genes under positive selection in different lineages play...
Abstract Epigenetic alterations and metabolic dysfunction are two hallmarks of aging. However, the mechanism how their interaction regulates aging, particularly in mammals, remains largely unknown. Here we show ELOVL fatty acid elongase 2 (Elovl2), a gene whose epigenetic most highly correlated with age prediction, contributes to aging by regulating lipid metabolism. We applied artificial intelligence predict protein structure ELOVL2 its substrate. Impaired Elovl2 function disturbs synthesis...
Abstract Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4 (GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However, wide application GPX4 in therapy is hampered due to poor delivery efficacy and nonspecific ferroptosis. Taking advantage vivo self-assembly, we develop peptide-ferriporphyrin conjugate with microenvironment specific improve penetration, endocytosis inhibition, ultimately enhancing its anticancer activity...
Several mechanisms have been proposed to account for the origination of new genes. Despite extensive case studies, general principles governing this fundamental process are still unclear at whole-genome level. Here, we unveil genome-wide patterns mutational leading genes and their subsequent lineage-specific evolution different time nodes in Drosophila melanogaster species subgroup. We find that (1) tandem gene duplication has generated ∼80% nascent duplicates limited single ( D. or yakuba...
Summary A new reverse genetics method has been developed to identify and isolate deletion mutants for targeted plant genes. Deletion mutant libraries are generated using fast neutron bombardment. DNA samples extracted from the used screen by polymerase chain reaction (PCR) specific primers flanking By adjusting PCR conditions preferentially amplify alleles, were identified in pools of samples, each pool containing 2592 lines. obtained 84% loci an Arabidopsis population 51 840 Using a similar...
Breast cancer is the second-leading cause of cancer-related deaths in women, but details how it begins remain elusive. Increasing evidence supports association aggressive triple-negative (TN) breast with heightened expression Polycomb group protein Enhancer Zeste Homolog 2 (EZH2) and increased tumor-initiating cells (TICs). However, mechanistic links between EZH2 TICs are unclear, direct demonstration a tumorigenic function vivo lacking. Here, we identify an unrecognized EZH2/NOTCH1 axis...
Since their arrival in the Tibetan Plateau during Neolithic Age, Tibetans have been well-adapted to extreme environmental conditions and possess genetic variation that reflect living environment migratory history. To investigate origin of basis adaptation a rigorous environment, we genotyped 30 individuals with more than one million SNP markers. Our findings suggested Tibetans, together Yi people, were descendants Tibeto-Burmans who diverged from ancient settlers East Asia. The valleys...
Aging and sun exposure are the leading causes of skin cancer. It has been shown that epigenetic changes, such as DNA methylation, well established mechanisms for cancer, also have emerging roles in aging common disease. Here, we directly ask whether methylation is altered following and/or chronic humans.We compare epidermis dermis both sun-protected sun-exposed derived from younger subjects (under 35 years old) older (over 60 old), using Infinium HumanMethylation450 array whole genome...
Methyltransferase-like 3 (METTL3) is the main enzyme for N6-methyladenosine (m6A)-based methylation of RNAs and it has been implicated in many biological pathophysiological processes. In this study, we aimed to explore potential involvement METTL3 osteoblast differentiation decipher underlying cellular molecular mechanisms. We demonstrated that downregulated human osteoporosis ovariectomized (OVX) mouse model, as well during osteogenic differentiation. Silence by short interfering RNA...
DNA methylation at the 5-position of cytosine (5mC) is an epigenetic modification that regulates gene expression and cellular plasticity in development disease. The ten-eleven translocation (TET) family oxidizes 5mC to 5-hydroxymethylcytosine (5hmC), providing active mechanism for demethylation, it may also provide its own regulatory function. Here we applied oxidative bisulfite sequencing generate whole-genome hydroxymethylation maps single-base resolution human normal liver lung as well...