About
Contact & Profiles
A5070702620
Research Areas
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
Vanderbilt University Medical Center
2017-2020
10.1038/ng.3753
article
EN
Nature Genetics
2017-01-16
Abstract Although metastasis is the most common cause of cancer deaths, metastasis-intrinsic dependencies remain largely uncharacterized. We previously reported that metastatic pancreatic cancers were dependent on glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Surprisingly, PGD catalysis was constitutively elevated without activating mutations, suggesting a non-genetic basis for enhanced activity. Here we report metabolic adaptation stably activates to reprogram chromatin....
10.1038/s41467-020-17839-5
article
EN
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Nature Communications
2020-08-13
10.1038/s41388-018-0346-5
article
EN
Oncogene
2018-05-30
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