A5074378026- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Cancer-related gene regulation
- Renal and related cancers
- Genetics and Neurodevelopmental Disorders
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Acute Myeloid Leukemia Research
- Genomics and Phylogenetic Studies
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- IL-33, ST2, and ILC Pathways
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2015-2024
University of Baltimore
2007-2024
Sidney Kimmel Comprehensive Cancer Center
2023-2024
Mount Sinai Hospital
2024
Thermo Fisher Scientific (Sweden)
2020
National Institutes of Health
2001-2016
National Heart Lung and Blood Institute
2016
Harvard University
2007-2014
University of Maryland, Baltimore
2014
Abstract Motivation: The recently released Infinium HumanMethylation450 array (the ‘450k’ array) provides a high-throughput assay to quantify DNA methylation (DNAm) at ∼450 000 loci across range of genomic features. Although less comprehensive than sequencing-based techniques, this product is more cost-effective and promises be the most widely used DNAm measurement technology over next several years. Results: Here we describe suite computational tools that incorporate state-of-the-art...
Abstract Background DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on levels. It is not yet known whether captures aspects biological Results Here we test differences between people’s ages and estimated ages, age, predict all-cause mortality in later life. The difference (Δ ) was calculated four longitudinal cohorts older people. Meta-analysis proportional hazards models from the used to determine association Δ mortality. A 5-year...
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard International Space Station; his served as genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension increased intima-media thickness, altered ocular structure, transcriptional metabolic DNA...
The methylation state of DNA from human colon tissue displaying neoplastic growth was determined by means restriction endonuclease analysis. When compared to adjacent normal tissue, both benign polyps and malignant carcinomas substantially hypomethylated. With the use probes for hormone, γ-globin, α-chorionic gonadotropin, γ-crystallin, changes were detected in all 23 growths examined. Benign hypomethylated a degree similar that tissue. These results indicate hypomethylation is consistent...
Loss of imprinting (LOI), an epigenetic alteration affecting the insulin-like growth factor II gene (IGF2), is found in normal colonic mucosa about 30% colorectal cancer (CRC) patients, but it only 10% healthy individuals. In a pilot study to investigate utility LOI as marker CRC risk, we evaluated 172 patients at colonoscopy clinic. The adjusted odds ratio for lymphocytes was 5.15 with positive family history [95% confidence interval (95% CI), 1.70 16.96; probability P = 0.002], 3.46...
Context Changes over time in epigenetic marks, which are modifications of DNA such as by methylation, may help explain the late onset common human diseases.However, changes methylation or other marks a given individual have not yet been investigated. ObjectivesTo determine whether there longitudinal global individuals and to evaluate maintenance demonstrates familial clustering. Design, Setting, ParticipantsWe measured luminometric assay, quantitative measurement genome-wide on sampled at 2...
During the past 5 years, high-throughput technologies have been successfully used by epidemiology studies, but almost all focused on sequence variation through genome-wide association studies (GWAS). Today, study of other genomic events is becoming more common in large-scale epidemiological studies. Many these, unlike single-nucleotide polymorphism studied GWAS, are continuous measures. In this context, exercise searching for regions interest disease akin to problems described statistical...