A5084820716- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Spaceflight effects on biology
- Dietary Effects on Health
- Sleep and related disorders
- Stress Responses and Cortisol
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Adipose Tissue and Metabolism
- Light effects on plants
- Neuroendocrine regulation and behavior
- Genetics, Aging, and Longevity in Model Organisms
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
- Hormonal and reproductive studies
- Gut microbiota and health
- Sperm and Testicular Function
- Sleep and Work-Related Fatigue
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Tryptophan and brain disorders
- Avian ecology and behavior
- Animal Nutrition and Physiology
- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
Northwestern University
2015-2024
Circadian (United States)
2009-2024
Institute of Neurobiology
2005-2023
Midwestern University
2018
Northwestern University
2018
Florida State University
2012
Canadian Sleep & Circadian Network
2000-2011
NorthShore University HealthSystem
2005
Howard Hughes Medical Institute
2001-2005
Université Libre de Bruxelles
1990-2003
The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, develop metabolic syndrome hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, hypoinsulinemia. Expression transcripts encoding selected peptides associated with energy balance was in mice. These results suggest gene...
In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened clock mutations. A semidominant mutation, Clock, lengthens period and abolishes persistence rhythmicity was identified. Clock segregated as single gene mapped to midportion mouse chromosome 5, region syntenic human 4. The power ENU mutagenesis combined ability clone murine by map position provides generally applicable approach study complex behavior mammals.
Studies of body weight regulation have focused almost entirely on caloric intake and energy expenditure. However, a number recent studies in animals linking the circadian clock at molecular, physiological, behavioral levels raise possibility that timing food itself may play significant role gain. The present study phase consumption We provide evidence nocturnal mice fed high-fat diet only during 12-h light gain significantly more than dark phase. A better understanding system for could...
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard International Space Station; his served as genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension increased intima-media thickness, altered ocular structure, transcriptional metabolic DNA...
Intestinal dysbiosis and circadian rhythm disruption are associated with similar diseases including obesity, metabolic syndrome, inflammatory bowel disease. Despite the overlap, potential relationship between disorganization is unknown; thus, in present study, a model of chronic was used to determine impact on intestinal microbiome. Male C57BL/6J mice underwent once weekly phase reversals light:dark cycle (i.e., disrupted mice) microbiome were fed either standard chow or high-fat, high-sugar...
Diurnal fluctuations of motor and nonmotor symptoms a high prevalence sleep-wake disturbances in Parkinson disease (PD) suggest role the circadian system modulation these symptoms. However, surprisingly little is known regarding function PD whether dysfunction involved development PD.To determine relationship between timing amplitude 24-hour melatonin rhythm, marker endogenous rhythmicity, with self-reported sleep quality, severity daytime sleepiness, metrics.A cross-sectional study from...
The circadian clock orchestrates temporal patterns of physiology and behavior relative to the environmental light:dark cycle by generating organizing transcriptional biochemical rhythms in cells tissues throughout body. Circadian genes have been shown regulate function gastrointestinal tract. Disruption intestinal epithelial barrier enables translocation proinflammatory bacterial products, such as endotoxin, across wall into systemic circulation; a process that has linked pathologic...
The onset and duration of sleep are thought to be primarily under the control a homeostatic mechanism affected by previous periods wake circadian timing that partitions into different portions day night. mouse Clock mutation induces pronounced changes in overall organization. We sought determine whether this genetic disruption would affect homeostasis. number parameters during entrainment 12 hr light/dark (LD 12:12) cycle, when animals were free-running constant darkness (DD), recovery from...
To examine the immediate phase-shifting effects of high-intensity exercise a practical duration (1 h) on human circadian phase, five groups healthy men 20–30 yr age participated in studies involving no or exposure to morning, afternoon, evening, nocturnal exercise. Except during scheduled sleep/dark and periods, subjects remained under modified constant routine conditions allowing sleep period including posture, knowledge clock time, dim light intensities averaging (±SD) 42 ± 19 lx. The...
The finding that deletion or mutation of core circadian clock genes in both mice and flies induce unexpected alterations sleep amount, architecture the recovery response to deprivation, has led new insights into functions system extend beyond its role as a regulator timing sleep-wake cycle. A key transcription factor transcriptional/translational feedback loop mammalian is BMAL1/Mop3, heterodimeric partner CLOCK. It was previously shown deficient BMAL1/Mop3 gene become immediately arrhythmic...
The effects of age on the circadian clock system have been extensively studied, mainly in two rodent species, laboratory rat and golden hamster. However, less information is available how aging alters rhythmicity a commonly studied animal model, mouse. Therefore, present study we compared rhythm wheel-running activity adult (6–9 mo) old (19–22 C57BL/6J mice maintained under different lighting conditions for period 4 mo. During this period, were subjected to phase advances delays light-dark...
Abstract Chronic sleep restriction is an increasing problem in many countries and may have many, as yet unknown, consequences for health well being. Studies both humans rats suggest that deprivation activate the hypothalamic‐pituitary‐adrenal (HPA) axis, one of main neuroendocrine stress systems. However, few attempts been made to examine how loss affects HPA axis response subsequent stressors. Furthermore, most studies applied short‐lasting total not over a longer period time, often occurs...