A5087760694- RNA Interference and Gene Delivery
- CNS Lymphoma Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Virus-based gene therapy research
- Lung Cancer Treatments and Mutations
- Endoplasmic Reticulum Stress and Disease
- Respiratory Support and Mechanisms
- Wound Healing and Treatments
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Protein Kinase Regulation and GTPase Signaling
- Immunotherapy and Immune Responses
- MRI in cancer diagnosis
- Alcohol Consumption and Health Effects
- Eosinophilic Esophagitis
- Metabolism, Diabetes, and Cancer
- Heavy Metal Exposure and Toxicity
- Atherosclerosis and Cardiovascular Diseases
- Biosimilars and Bioanalytical Methods
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
Taipei Medical University
2021-2024
New York Blood Center
2023
Vanderbilt University Medical Center
2020-2021
National Taiwan University Hospital
2017-2021
Taipei Medical University Hospital
2021
Fu Jen Catholic University
2020-2021
Texas College
2020
University of North Texas
2020
University of North Texas Health Science Center
2020
Monash Health
2018-2019
The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, develop metabolic syndrome hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, hypoinsulinemia. Expression transcripts encoding selected peptides associated with energy balance was in mice. These results suggest gene...
Rationale:The TNF-α pathway plays as a double-edged sword that simultaneously regulates cell apoptosis and proliferation.The dysregulated signaling can trigger cytokine storms lead to profound death during the phase of acute tissue injury.On other hand, an optimal level is required for repair following injury phase.The commonly upregulated in lung (ALI) liver failure (ALF).Previous studies investigated feasibility adopting protein-based blockers disease modifiers ALI ALF, but none these came...
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterised by biological and clinical heterogeneity. The interleukin (IL)-1 superfamily group of innate cytokines which contribute to pathogenesis in many diseases. IL-1b IL-18 are two members that have been shown play role murine lupus-like models, but their human SLE remains poorly understood. Here, was quantified ELISA the serum healthy controls patients from prospectively followed cohort. Disease activity...
Abstract The blood brain barrier (BBB) is often an insurmountable obstacle for a large number of candidate drugs, including peptides, antibiotics and chemotherapeutic agents. Devising adroit delivery method to cross the BBB essential unlocking widespread application peptide therapeutics. Presented here engineered nanocontainer delivering peptidic drugs across encapsulating analgesic marine snail ziconotide (Prialt®). We developed bi-functional viral based on Salmonella typhimurium...
The successful translation of cytotoxic T lymphocyte antigen-4 (CTLA-4) blockade has revolutionized the concept cancer immunotherapy. Although monoclonal antibody therapeutics remain mainstream in clinical practice, aptamers are synthetic oligonucleotides that encompass antibody-mimicking functions. Here, we report a novel high-affinity CTLA-4-antagonizing DNA aptamer (dissociation constant, 11.84 nM), aptCTLA-4, which was identified by cell-based SELEX and high-throughput sequencing....
The c-Jun N-terminal kinases (JNKs) have been implicated in the development of insulin resistance, diabetes, and obesity. Genetic disruption JNK1, but not JNK2, improves sensitivity diet-induced obese (DIO) mice. We applied RNA interference to investigate specific role hepatic JNK1 contributing resistance DIO Adenovirus-mediated delivery short-hairpin (Ad-shJNK1) resulted almost complete knockdown protein without affecting other tissues. Liver-specific significant reductions circulating...
Abstract Objectives Systemic sclerosis ( SS c) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of c remains poorly understood, although studies have indicated a role for the innate response. Methods Here, we measured serum interleukin IL )‐1α, ‐1β ‐18 levels in 105 patients 47 healthy controls HC ) analysed them with respect to multiple clinical parameters. Results Serum concentrations were significantly higher than , while...
Summary Intravascular large B‐cell lymphoma ( IVLBCL ) is a rare entity, with generally aggressive course that may vary based on geographic presentation. While United States US registry study showed relatively good outcomes , clinicopathological and treatment data were unavailable. We performed detailed retrospective review of cases identified at 8 medical centres, to improve understanding inform management. compiled retrieved via an Institutional Review Board‐approved from 1999 2015 nine...
Abstract Objectives Macrophage migration inhibitory factor ( MIF ) and D‐dopachrome tautomerase DDT ), members of the same cytokine superfamily, are linked to pathogenesis a number inflammatory diseases. The aim this study was investigate their clinical relevance in systemic sclerosis SS c). Methods Serum were quantified 105 c patients by ELISA levels compared healthy controls HC (47) with lupus erythematosus SLE (184). Clinical parameters included organ involvement, serum laboratory markers...
In immune checkpoint inhibitor (ICI) trials, long tails and crossovers in survival curves-which violate the proportional hazards (PH) assumption-are commonly observed, making cure or restricted mean time models preferable for analysis of ICI data. Cox PH analysis, however, still appears major medical journals, leading to potential misinterpretation clinical significance.To convert inappropriate hazard ratios (HRs) appropriate model treatment-effect estimates (HR short-term survivors...
Abstract The Taiwan Precision Medicine Initiative (TPMI), a project initiated by the Academia Sinica in collaboration with 16 major medical centers around Taiwan, has recruited 565,390 participants who consented to provide DNA samples for genetic profiling and grant access their electronic records (EMR) studies develop precision medicine. Access EMR is both retrospective prospective, allowing researchers conduct prospective over time. Genetic done population-optimized SNP arrays Han Chinese...
The high 5-year disease relapse rate in patients with stage I lung adenocarcinoma indicates the need for additional risk stratification parameters. This study assessed whether gene signatures translate into a pathologic feature better stratification.The mutual interdependence and power of three signatures, cell cycle, hypoxia, mammalian target rapamycin (mTOR), were investigated nine cohorts five squamous carcinoma. translation from to feature, tumor necrosis, was validated Cancer Genome...
Purpose Associations between Asian lung cancer (LC) and breast (BC) are unknown. This study evaluates associations LC BC in the Taiwan population. Methods was based on National Health Insurance data Cancer Registry. The cohorts included women with newly diagnosed or 2000 2011 an age- sex-stratified random sample as a noncancer comparison cohort during same period. Cox proportional hazards regression analysis used to determine risks. University Hospital (NTUH) cohort, which comprised patients...