A5031571854- Cancer, Lipids, and Metabolism
- Advanced Breast Cancer Therapies
- Groundwater flow and contamination studies
- Cancer Mechanisms and Therapy
- Estrogen and related hormone effects
- Hydraulic Fracturing and Reservoir Analysis
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Neonatal Respiratory Health Research
- Ovarian cancer diagnosis and treatment
- Hepatitis C virus research
- Genetics, Aging, and Longevity in Model Organisms
- Lung Cancer Research Studies
- Bariatric Surgery and Outcomes
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Molecular Biology Techniques and Applications
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- RNA Research and Splicing
- HIV, Drug Use, Sexual Risk
- PARP inhibition in cancer therapy
- SARS-CoV-2 and COVID-19 Research
- Radio Frequency Integrated Circuit Design
Tainan Municipal Hospital
2022-2024
Taichung Veterans General Hospital
2022-2024
National Cheng Kung University Hospital
2021-2024
Asia University
2024
National Taipei University of Technology
2021-2024
Chung Hwa University of Medical Technology
2024
National Yang Ming Chiao Tung University
2007-2023
National Taiwan University
2011-2023
Yuan Ze University
2023
National Tsing Hua University
2009-2022
An insulin-modified frequently sampled intravenous glucose tolerance test (FSIGTT) with minimal model analysis was compared the clamp in 11 subjects normal (NGT), 20 impaired (IGT), and 24 non-insulin-dependent diabetes mellitus (NIDDM). The insulin sensitivity index (SI) calculated from FSIGTT using 22- 12-sample protocols (SI(22) SI(12), respectively). Insulin expressed as SI(clamp) SIP(clamp). Minimal parameters were similar when SI(22) SI(12). SI could not be distinguished 0 ∼ 50% of...
OBJECTIVE To describe features of pediatric-onset type 2 diabetes in the Hispanic population. RESEARCH DESIGN AND METHODS The medical records 55 subjects with who were treated from 1990 to 1994 a pediatric clinic serving lower income Mexican-Americans reviewed assess frequency and clinical diabetes. Additionally, nondiabetic siblings several patients underwent oral glucose tolerance testing, survey six high schools same county was performed. RESULTS Seventeen (31%) diabetic children...
One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status human leukocyte antigen (HLA) types in September 2006, 3 y after the SARS outbreaks Taiwan. Western blot assay showed that 6.9% participants still had anti-spike anti-nucleocapside antibodies. A case-control study association HLA with revealed HLA-Cw1502 DR0301 alleles conferred resistance against infection (p<0.05).
Rationale: PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies. However, it is unclear whether studies–identified genes, including PPAP2B , participate mechanotransduction mechanisms which vascular endothelia respond to local atherorelevant hemodynamics contribute the regional nature of atherosclerosis....
Plasma glucose values after oral challenge vary widely in nondiabetic subjects. We have now evaluated the role of insulin resistance determining plasma response to 74 volunteer subjects with normal tolerance. In these subjects, we determined and responses over a 3-h period 75-g challenge, steady-state concentration during continuous infusion somatostatin, glucose, (a quantitative measure resistance). The was defined as incremental increase above fasting value for 3 h challenge. Multiple...
Transcriptionally non-co-linear (NCL) transcripts can originate from trans-splicing (trans-spliced RNA; 'tsRNA') or cis-backsplicing (circular 'circRNA'). While numerous circRNAs have been detected in various species, tsRNAs remain largely uninvestigated. Here, we utilize integrative transcriptome sequencing of poly(A)- and non-poly(A)-selected RNA-seq data diverse human cell lines to distinguish between circRNAs. We identified 24,498 NCL events found that a considerable proportion (20-35%)...
Abstract Extracellular particles (EPs) including extracellular vesicles (EVs) and exomeres play significant roles in diseases therapeutic applications. However, their spatiotemporal dynamics vivo have remained largely unresolved detail due to the lack of a suitable method. Therefore, bioluminescence resonance energy transfer (BRET)‐based reporter, PalmGRET, is created enable pan‐EP labeling ranging from (<50 nm) small (<200 medium large (>200 EVs. PalmGRET emits robust, sustained...
Abstract Activated epidermal growth factor receptor (EGFR) has been proposed in the pathophysiology of neurodegenerative diseases. In present study, anti-inflammatory effect afatinib, an EGFR-tyrosine kinase inhibitor (EGFR-TKIs) was investigated using CTX-TNA2 cells and primary cultured astrocytes subjected to oxygen/glucose deprivation (OGD). We found that OGD induced EGFR phosphorylation activated subsequent signaling pathways, including AKT extracellular signal-regulated kinases (ERK)....
Circular RNAs (circRNAs), a class of long noncoding RNAs, are known to be enriched in mammalian neural tissues. Although wide range dysregulation gene expression autism spectrum disorder (ASD) have been reported, the role circRNAs ASD remains largely unknown. Here, we performed genome-wide circRNA profiling postmortem brains from individuals with and controls identified 60 three coregulated modules that were perturbed ASD. By integrating circRNA, microRNA, mRNA data derived same cortex...
Water electrolysis is one of the most common methods to produce hydrogen gas with high purity, but its application limited due low energy efficiency. It has been proved that an external magnetic field can reduce consumption and increase production efficiency in water electrolysis. In this study, electrodes different magnetism were subjected a perpendicular for use by Gas bubbles evolve from surface horizontal electrode detach faster than vertical electrode. The locomotion facilitated if...
Abstract Human immunodeficiency virus type 1 (HIV‐1) circulating recombinant form (CRF) 07_BC strain has caused serious outbreaks among injection drug users in Taiwan since 2004. The objective of this study was to conduct a molecular epidemiological HCV genotypes intravenous Taiwan. Blood samples and questionnaires from 591 infected with HIV‐1 were collected nationwide. In total, 180 selected for genotyping using multiplex PCR phylogenetic analysis the core, E1 NS5B regions. Inno‐Lipa assay...
Cell-free circulating DNA (cfDNA) is becoming a useful biopsy for noninvasive diagnosis of diseases. Microbial sequences in plasma cfDNA may provide important information to improve prognosis and treatment. We have developed stringent method identify microbial species via the blood early-onset breast cancer (EOBC) patients healthy females. Empirically, microbe-originated sequence reads were identified by mapping non-human PE libraries databases. Those mapped concordantly unique assembled...
Although colloidal lead halide perovskite quantum dots (PQDs) exhibit desirable emitter characteristics with high yields and narrow bandwidths, instability has limited their applications in devices. In this paper, we describe spray-synthesized CsPbI3 PQD emitters displaying strong photon antibunching brightness at room temperature stable performance under continuous excitation a high-intensity laser for more than 24 h. Our PQDs provided single-photon emission rates, exceeding 9 × 106...
Abstract Our previous research identified interleukin‐4 (IL‐4) as a key regulator of glucose/lipid metabolism, circulatory leptin levels, and insulin action, suggesting its potential therapeutic target for obesity related complications. This study aimed to further elucidate the role IL‐4 in regulating hypothalamic appetite‐controlling neuropeptides using dysfunctional Leptin 145E/145E mice experimental model. significantly reduces body weight, food intake, serum glucose levels. data...
Abstract PURPOSE: Intravitreal injections (IVIs) have been the most important treatment strategies in retinal diseases. With increasing use of IVIs, incidence endophthalmitis has inevitably risen. Triamcinolone acetonide (TA) used IVIs suspected as a risk factor for post-IVI endophthalmitis. This study investigates incidence, clinical presentations, and microscopic findings with or without TA, aiming to provide better understanding this issue. MATERIALS AND METHODS: retrospective included...
Abstract By using RNA-immunoprecipitation assay following next-generation sequencing, a group of cell cycle-related genes targeted by hnRNP Q1 were identified, including Aurora-A kinase. Overexpressed can upregulate protein, but not alter the mRNA level, through enhancing translational efficiency mRNA, either in cap-dependent or -independent manner, interacting with 5′-UTR its RNA-binding domains (RBDs) 2 and 3. ribosomal profiling further confirmed regulation Q1. Overexpression promotes...
Abstract Our aim was to develop a machine learning-based predictor for early mortality and severe intraventricular hemorrhage (IVH) in very-low birth weight (VLBW) preterm infants Taiwan. We collected retrospective data from VLBW infants, dividing them into two cohorts: one model development internal validation (Cohort 1, 2016–2021), another external 2, 2022). Primary outcomes included mortality, IVH, poor (a combination of both). Data preprocessing involved 23 variables, with the top four...
Hypertension (HTN) represents a complex heritable disease in which environmental factors may directly affect gene function via epigenetic mechanisms. The aim of this study was to test the hypothesis that dietary salt influences activity histone-modifying enzyme, lysine-specific demethylase 1 (LSD-1), turn is associated with salt-sensitivity blood pressure (BP). Animal and human studies were performed. Salt-sensitivity LSD-1 expression assessed wild-type (WT) heterozygote knockout (LSD-1+/−)...
// Chung-Chun Wu 1 , Chih-Yeu Fang 1, 4 Hui-Yu Hsu Hsin-Ying Chuang Yu-Jhen Cheng Yen-Ju Chen Sheng-Ping Chou Sheng-Yen Huang Su-Fang Lin Yao Chang 2 Ching-Hwa Tsai 3 Jen-Yang National Institute of Cancer Research, Health Research Institutes, Zhunan, Taiwan Infectious Diseases and Vaccinology, Tainan, Department Microbiology, College Medicine, University, Taipei, Pathology, Wan Hospital, Taipei Medical Correspondence to: Chen, e-mail: cjy@nhri.org.tw Keywords: nasopharyngeal carcinoma,...