A5072245580- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- Additive Manufacturing and 3D Printing Technologies
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Axon Guidance and Neuronal Signaling
- Congenital heart defects research
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Pluripotent Stem Cells Research
- Photoacoustic and Ultrasonic Imaging
- Silk-based biomaterials and applications
- Optical Imaging and Spectroscopy Techniques
- Hippo pathway signaling and YAP/TAZ
- Zebrafish Biomedical Research Applications
- Cancer Cells and Metastasis
- Geothermal Energy Systems and Applications
- Cardiac and Coronary Surgery Techniques
- Hydrogels: synthesis, properties, applications
- Neurogenesis and neuroplasticity mechanisms
- Osteoarthritis Treatment and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Cell Image Analysis Techniques
- Advanced Neural Network Applications
- Mesenchymal stem cell research
Northeastern University
2017-2025
Tianjin University
2025
Lanzhou Jiaotong University
2025
Shanghai Jiao Tong University
2023-2024
Maternal and Child Health Care Hospital of Bao'an
2024
Hohai University
2024
Wuhan Institute of Technology
2024
Shenzhen University
2023
Heilongjiang Bayi Agricultural University
2022
Rensselaer Polytechnic Institute
2010-2018
Three-dimensional (3D) bioprinting, a flexible automated on-demand platform for the free-form fabrication of complex living architectures, is novel approach design and engineering human organs tissues. Here, we demonstrate potential 3D bioprinting tissue using skin as prototypical example. Keratinocytes fibroblasts were used constituent cells to represent epidermis dermis, collagen was dermal matrix skin. Preliminary studies conducted optimize printing parameters maximum cell viability well...
In the face of systemic risk factors, certain regions arterial vasculature remain relatively resistant to development atherosclerotic lesions. The biomechanically distinct environments in these geometries exert a protective influence via key functions endothelial lining; however, mechanisms underlying coordinated regulation specific mechano-activated transcriptional programs leading functional phenotypes have remained elusive. Here, we show that transcription factor Kruppel-like 2 (KLF2) is...
Atherosclerotic lesion localization to regions of disturbed flow within certain arterial geometries, in humans and experimental animals, suggests an important role for local hemodynamic forces atherogenesis. To explore how endothelial cells (EC) acquire functional/dysfunctional phenotypes response vascular region-specific patterns, we have used vitro dynamic system accurately reproduce shear stress waveforms on cultured human EC examined the effects gene expression by using a high-throughput...
Abstract Bioprinting based on thermal inkjet printing is a promising but unexplored approach in bone tissue engineering. Appropriate cell types and suitable biomaterial scaffolds are two critical factors to generate successful bioprinted tissue. This study was undertaken order evaluate bioactive ceramic nanoparticles stimulating osteogenesis of printed marrow‐derived human mesenchymal stem cells (hMSCs) poly(ethylene glycol)dimethacrylate (PEGDMA) scaffold. hMSCs suspended PEGDMA were...
Abstract Inkjet bioprinting is one of the most promising additive manufacturing approaches for tissue fabrication with advantages high speed, resolution, and low cost. The limitation this technology potential damage to printed cells frequent clogging printhead. Here we developed acrylated peptides co‐printed poly(ethylene glycol) (PEG) hydrogel simultaneous photopolymerization. At same time, bone marrow‐derived human mesenchymal stem (hMSCs) were precisely during scaffold process so...
Multilayered skin substitutes comprising allogeneic cells have been tested for the treatment of nonhealing cutaneous ulcers. However, such nonnative grafts fail to permanently engraft because they lack dermal vascular networks important integration with host tissue. In this study, we describe fabrication an implantable multilayered vascularized bioengineered graft using 3D bioprinting. The is formed one bioink containing human foreskin fibroblasts (FBs), endothelial (ECs) derived from cord...
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, have been shown to positively impact vascular function independent of their plasma lipid-lowering action. Several these beneficial effects involve modulation gene expression. Here we explored whether the transcription factor Kruppel-like 2 (KLF2), a biomechanically activated recently identified as part endothelial "atheroprotective phenotype," is regulated by statins and this mechanism important for non-lipid lowering...
Local patterns of biomechanical forces experienced by endothelial cells (ECs) in different vascular geometries appear to play an essential role regulating EC function and determining the regional susceptibility atherosclerosis, even face systemic risk factors. To study how regulate redox homeostasis, important pathogenic factor atherogenesis, we have cultured human ECs under 2 prototypic arterial shear stress waveforms, “atheroprone” “atheroprotective,” which were derived from distinct...
Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), results inflammation ultimately atherosclerosis. However, how DF alters EC metabolism, whether resulting metabolic changes induce activation, is unknown. Using transcriptomics bioenergetic analysis, we discovered that induces glycolysis reduces mitochondrial respiratory capacity human aortic ECs. DF-induced reprogramming required hypoxia...
Cell printing is becoming a common technique to fabricate cellularized printed scaffold for biomedical application. There are still significant challenges in soft tissue bioprinting using hydrogels, which requires live cells inside the hydrogels. Moreover, resilient mechanical properties from hydrogels also required mechanically mimic native tissues. Herein, we developed visible-light cross-linked, single-network, biodegradable hydrogel with high elasticity and flexibility cell printing,...
Rationale: PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies. However, it is unclear whether studies–identified genes, including PPAP2B , participate mechanotransduction mechanisms which vascular endothelia respond to local atherorelevant hemodynamics contribute the regional nature of atherosclerosis....
Abstract The success of engineered cell or tissue implants is dependent on vascular regeneration to meet adequate metabolic requirements. However, development a broadly applicable strategy for stable and functional vascularization has remained challenging. We report here highly organized resilient microvascular meshes fabricated through controllable anchored self-assembly method. are scalable centimeters, almost free defects transferrable diverse substrates, ready transplantation. They...
Mesoscopic fluorescence molecular tomography enables longitudinal study of 3D glioblastoma model in response to drug treatment.
Abstract Antimony sulfide (Sb 2 S 3 ) has attracted extensive attention due to its excellent photoelectric characteristics, including a high absorption coefficient (α > 10 4 cm −1 and suitable bandgap (≈1.7 eV). However, Q1D (quasi‐1D) structure, numerous deep‐level defects are identified in the Sb film, limiting device's performance, necessitating more efforts overcome this situation. In context, an ethanol solvent‐assisted chemical bath deposition (S‐CBD) strategy, novel high‐quality...
Abstract Short‐wave infrared (SWIR) organic photodetectors (OPDs) offer flexibility, cost‐effectiveness, and tunable properties that differentiate them from commercially inorganic SWIR photodetectors. These detectors mainly rely on materials possessing absorption properties. However, the synthesis of new semiconductor with narrow band gaps remains a significant challenge. Here an effective general strategy blending TMBP‐F 4 TCNQ (TMF4) cocrystal PDVT‐10 polymer as SWIR‐absorbing for...