A5053047041- Ferroelectric and Piezoelectric Materials
- Acoustic Wave Resonator Technologies
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Multiferroics and related materials
- Nanoplatforms for cancer theranostics
- Polymer Surface Interaction Studies
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Diabetes Management and Research
- Tissue Engineering and Regenerative Medicine
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Microwave Dielectric Ceramics Synthesis
- Extracellular vesicles in disease
- Hydrogels: synthesis, properties, applications
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Dendrimers and Hyperbranched Polymers
- Dielectric materials and actuators
- Electronic and Structural Properties of Oxides
- Conducting polymers and applications
- Magnetic Properties and Applications
University of Science and Technology of China
2016-2025
Hefei National Center for Physical Sciences at Nanoscale
2019-2025
Hubei University
1996-2024
Cornell University
2017-2023
Chinese Academy of Sciences
2015-2022
Anhui University of Traditional Chinese Medicine
2022
Beijing University of Posts and Telecommunications
2022
Hefei University
2014-2021
Ithaca College
2018-2019
Tianjin University
2019
Abstract Hydrogels with adhesive properties have potential for numerous biomedical applications. Here, the design of a novel, intrinsically hydrogel and its use in developing internal therapeutic bandages is reported. The involves incorporation “triple hydrogen bonding clusters” (THBCs) as side groups into matrix. THBC through unique “load sharing” effect an increase bond density results strong adhesions to range surfaces, including glass, plastic, wood, poly(tetrafluoroethylene) (PTFE),...
Foreign body reaction (FBR) to implanted biomaterials and medical devices is common can compromise the function of implants or cause complications. For example, in cell encapsulation, cellular overgrowth (CO) fibrosis around constructs reduce mass transfer oxygen, nutrients metabolic wastes, undermining leading transplant failure. Therefore, materials that mitigate FBR CO will have broad applications biomedicine. Here we report a group zwitterionic, sulfobetaine (SB) carboxybetaine (CB)...
Transplantation of stem cell-derived β (SC-β) cells represents a promising therapy for type 1 diabetes (T1D). However, the delivery, maintenance, and retrieval these remain challenge. Here, we report design safe functional device composed highly porous, durable nanofibrous skin an immunoprotective hydrogel core. The consists electrospun medical-grade thermoplastic silicone-polycarbonate-urethane is soft but tough (~15 megapascal at rupture strain >2). Tuning nanofiber size to less than ~500...
Chemodynamic therapy based on Fe2+-catalyzed Fenton reaction holds great promise in cancer treatment. However, low-produced hydroxyl radicals tumor cells constitute its severe challenges because of the fact that Fe2+ with high catalytic activity could be easily oxidized into Fe3+ low activity, greatly lowering efficacy. Here, we codeliver CuS iron-containing prodrug cells. In cells, overproduced esterase cleave phenolic ester bond to release Fe2+, activating produce radical. Meanwhile, act...
Abstract During the last two decades, cationic polymers have become one of most promising synthetic vectors for gene transfection. However, weak interactions formed between DNA and result in low transfection efficacy. Furthermore, polyplexes generally exhibit poor stability toxicity because large excess polymer typically required complete condensation. Herein, we report preparation a novel class bioreducible nanomicelles by use disulfide bonds to connect shell fluorocarbon core. These form...
Abstract The success of engineered cell or tissue implants is dependent on vascular regeneration to meet adequate metabolic requirements. However, development a broadly applicable strategy for stable and functional vascularization has remained challenging. We report here highly organized resilient microvascular meshes fabricated through controllable anchored self-assembly method. are scalable centimeters, almost free defects transferrable diverse substrates, ready transplantation. They...
Abstract Inadequate oxygenation is a major challenge in cell encapsulation, therapy which holds potential to treat many diseases including type I diabetes. In such systems, cellular oxygen (O 2 ) delivery limited slow passive diffusion from transplantation sites through the poorly O -soluble encapsulating matrix, usually hydrogel. This constrains maximum permitted distance between encapsulated cells and host site within few hundred micrometers ensure function. Inspired by natural gas-phase...
A cell encapsulation system generates oxygen from carbon dioxide for self-oxygenation.
Encapsulation of insulin-producing cells is a promising strategy for treatment type 1 diabetes. However, engineering an encapsulation device that both safe (i.e., no cell escape and breakage) functional low foreign-body response (FBR) high mass transfer) remains challenge. Here, family zwitterionic polyurethanes (ZPU) with sulfobetaine groups in the polymer backbone developed, which are fabricated into devices tunable nanoporous structures via electrospinning. The ZPU hydrophilic...
Recently, more and conductive nanocomposites are used to enhance the sensing characteristic of flexible sensors. However, influence composite structure on performance sensor is rarely investigated. Herein, two structures carbon black (CB)/graphene nanosheets (GNs) for three-dimensional piezoresistive Based CB GNs, three sensors with GNs fabricated. Experimental results show that different result in several times differences sensitivity gauge factor. Among samples, (first coating then filling...
Inhibitors of the PD-1/PD-L1 immune checkpoint have revolutionized cancer treatment. However, clinical response remains limited, with only 20% patients benefiting from treatment and approximately 60% PD-L1-positive exhibiting resistance. One key factor contributing to resistance is externalization phosphatidylserine (PS) on surface cells, which suppresses responses promotes PD-L1 expression, further hindering efficacy blockade therapies. Here, we introduce a copper chelate composed...
Pesticide sprayed onto plant leaves tends to discharge into the environment through rainwater washing, leaching, and volatilization, resulting in severe pollution soil, water, air. Here, control pesticide loss, we developed a loss-control (LCP) by adding straw ash-based biochar biosilica (BCS) traditional pesticide. BCS possesses porous micro/nano structure thus can adsorb large amount of molecules form pesticide-BCS complexes that tend be retained rough surface leaves, displaying high...
Cyclic polymers have a number of unique physical properties compared with those their linear counterparts. However, the methods for synthesis cyclic are very limited, and some multicyclic still not accessible now. Here, we found that five-membered structure electron withdrawing groups make methylene in rhodanine highly active to aldehyde via efficient Knoevenagel reaction. Also, can act as an initiator anionic ring-opening polymerization thiirane produce polythioethers. Therefore, serve both...
Sequential Michael addition-based thiol–ene and free radical mediated reactions for preparing sequence-ordered polymers are reported the first time.
Abstract Islet encapsulation and transplantation promises to improve upon current treatments for type 1 diabetes mellitus, though several limitations remain. Macroscale devices have been designed in vivo retrieval, but traditional geometries do not support clinically adequate mass transfer of nutrients insulin from the encapsulated tissue. Microcapsule technologies improved properties, their clinical translation remains challenging as complete retrieval is difficult, should graft become a...
Abstract Encapsulation and transplantation of insulin‐producing cells offer a promising curative treatment for type 1 diabetes (T1D) without immunosuppression. However, biomaterials used to encapsulate often elicit foreign body responses, leading cellular overgrowth deposition fibrotic tissue, which in turn diminishes mass transfer from transplanted cells. Meanwhile, the encapsulation device must be safe, scalable, ideally retrievable meet clinical requirements. Here, durable safe...
A verteporfin-loaded biodegradable hydrogel (VP-gel) was synthesized using hyaluronic acid and thiol-terminated 4-arm polyethylene glycol, with anti-scarring antibacterial activity to promote wound healing mitigate scar formation.
Review of emerging advances and persisting challenges in the engineering translation islet encapsulation technologies.