A5084755620- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Advanced Polymer Synthesis and Characterization
- CRISPR and Genetic Engineering
- MXene and MAX Phase Materials
- Bacterial Genetics and Biotechnology
- Photodynamic Therapy Research Studies
- Antibiotic Resistance in Bacteria
- Cyclopropane Reaction Mechanisms
- Click Chemistry and Applications
- Bone Tissue Engineering Materials
- Molecular Communication and Nanonetworks
- Advanced Photocatalysis Techniques
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Electrospun Nanofibers in Biomedical Applications
- Advanced Memory and Neural Computing
- Microbial Inactivation Methods
- 3D Shape Modeling and Analysis
- Advanced Drug Delivery Systems
University of Science and Technology of China
2019-2025
Hefei National Center for Physical Sciences at Nanoscale
2019-2025
Shanghai Dianji University
2024
Sun Yat-sen University
2024
Chinese Academy of Sciences
2022-2023
Fujian Institute of Research on the Structure of Matter
2023
Fuzhou University
2023
Nanfang Hospital
2022
Southern Medical University
2022
Hefei University
2020-2021
In order to address the dire need for new antibiotics treat specific strains of drug resistant Gram-negative bacterial infections, a mixed ligand analog natural Acinetobacter baumannii selective siderophore, fimsbactin, was coupled daptomycin, Gram-positive only antibiotic. The resulting conjugate 11 has potent activity against multidrug A. both in vitro and vivo. study also indicates that conjugation siderophores "drugs" are much larger than siderophore (iron transport agent) itself...
Inhibitors of the PD-1/PD-L1 immune checkpoint have revolutionized cancer treatment. However, clinical response remains limited, with only 20% patients benefiting from treatment and approximately 60% PD-L1-positive exhibiting resistance. One key factor contributing to resistance is externalization phosphatidylserine (PS) on surface cells, which suppresses responses promotes PD-L1 expression, further hindering efficacy blockade therapies. Here, we introduce a copper chelate composed...
Cyclic polymers have a number of unique physical properties compared with those their linear counterparts. However, the methods for synthesis cyclic are very limited, and some multicyclic still not accessible now. Here, we found that five-membered structure electron withdrawing groups make methylene in rhodanine highly active to aldehyde via efficient Knoevenagel reaction. Also, can act as an initiator anionic ring-opening polymerization thiirane produce polythioethers. Therefore, serve both...
Highly hydrophilic modification enhances the selectivity of targeted photosensitizer delivery.
Protonated cyano-modified carbon nitride was synthesized, and it could store photoelectrons with a lifetime of one month. The stored electrons drive polymerization in the dark avoid photodegradation compared to direct photopolymerization.
Antimicrobial resistance in Gram-negative bacteria has become one of the leading causes morbidity and mortality a serious worldwide public health concern due to fact that have an additional outer membrane protecting them from unwanted compound invading. It is still very difficult for antimicrobials reach intracellular targets challenging treat with current strategies. Here, we found (o-(bromomethyl)phenyl)boronic acid was incorporated into poly((2-N,N-diethyl)aminoethyl acrylate) (PDEA),...
Phytophthora drechsleri is a prevalent spoilage-associated organism found in fruits and vegetables that causes serious economic loss public health concern. Lactiplantibacillus plantarum one of the most promising candidates for use food as fungal antagonist biodetoxification agent. In this study, 347 L. strains were preliminarily evaluated antifungal activity against P. Tucker. Only 5.48% L.plantarum tested exerted strong antagonism IMAU70087 showed greatest inhibitory exhibited broad seven...
Black phosphorus (BP) has exhibited excellent biocompatibility and high photothermal conversion efficiency under near-infrared light, which makes it very promising for therapy. However, practical applications are highly hampered because lacks a targeting property rapidly degrades in cancer cells, especially response to strong intracellular oxidative stress. Here, we reported that the mitochondrial peptide functionalized black nanosheets covered with an acid-labile polymer shell (doubly...
A newly designed, dual-functional probe based on intracellular activation has been successfully developed for the detection of cancer cells.
In a tumor, the abnormal cancer cell proliferation results in an insufficient O2 supply, and meanwhile cells consume very fast. The imbalance between low oxygen supply overwhelming consumption concentration solid tumors. Therefore, order to relieve hypoxia tumors, it is necessary not only sustainably generate O2, but also inhibit mitochondrial respiration simultaneously. Here, we found that single Ti2C(OH)2 nanomaterial can simultaneously highly inhibits via binding phosphorylation proteins...
Hydrogels with strong adhesion to wet tissues are considered promising for wound dressings. However, the clinical application of adhesive hydrogel dressing remains a challenge due issues secondary damage during changes. Herein, we fabricated an adhesion-switchable formed poly(acrylamide)-co-poly(N-isopropyl acrylamide), quaternary ammonium chitosan and tannic acid. This forms instant robust skin at body temperature. as temperature rises above lower critical solution (LCST), loses its towards...
External stimuli triggering chemical reactions in cancer cells to generate highly reactive species are very appealing for therapy, which external irradiation activating sensitizers transfer energy or electrons surrounding oxygen other molecules is critical generating cytotoxic species. However, poor light penetration into tissue, low activity of sensitizers, and reliance on supply restrict the generation hypoxic tumors, lowers therapeutic efficacy. Here, this work presents galvanic cell...
Widening the photoresponse range while enhancing electrical properties of semiconductors could reduce complexity and cost photodetectors or increase power conversion efficiency solar cells. Surface doping through charge transfer with organic species is one most effective widely used approaches to achieve this aim. It usually features easier preparation over other methods but still limited by low physicochemical stability high improvement properties. This work shows unprecedented surface...
An ultrasound-triggered sonodynamic therapy has shown great promise for cancer therapy. However, its clinical applications are very limited because the traditional sonosensitizers tend to suffer from poor efficiency combined with low retention in cells and tumor selectivity. Therefore, higher effectivity, cell retention, specificity highly required. Herein, we constructed a Ti2C(OH)X nanosheet, which was sonosensitizer but had long circulation blood system. it interesting find that...