A5101557095- Antibiotic Resistance in Bacteria
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Bacterial Genetics and Biotechnology
- Plant Pathogenic Bacteria Studies
- Antimicrobial Peptides and Activities
- Legume Nitrogen Fixing Symbiosis
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Synthesis of β-Lactam Compounds
- Biochemical and Molecular Research
- Infectious Diseases and Mycology
- Microbial Natural Products and Biosynthesis
- Gold and Silver Nanoparticles Synthesis and Applications
- Mycotoxins in Agriculture and Food
- Insect and Pesticide Research
- Microbial Metabolism and Applications
- Biosensors and Analytical Detection
- Teratomas and Epidermoid Cysts
- Plant-Microbe Interactions and Immunity
- Antimicrobial agents and applications
- RNA and protein synthesis mechanisms
- Antimicrobial Resistance in Staphylococcus
Hsiri Therapeutics (United States)
2018-2020
Indiana University South Bend
2018
Punjab Agricultural University
2017
University of Connecticut
2011
University of Notre Dame
1995-1998
Centre hospitalier de l'Université Laval
1996
In order to address the dire need for new antibiotics treat specific strains of drug resistant Gram-negative bacterial infections, a mixed ligand analog natural Acinetobacter baumannii selective siderophore, fimsbactin, was coupled daptomycin, Gram-positive only antibiotic. The resulting conjugate 11 has potent activity against multidrug A. both in vitro and vivo. study also indicates that conjugation siderophores "drugs" are much larger than siderophore (iron transport agent) itself...
Development of resistance to antibiotics is a major medical problem. One approach extending the utility our limited antibiotic arsenal repurpose by altering their bacterial selectivity. Many that are used treat infections caused Gram-positive bacteria might be made effective against Gram-negative infections, if they could circumvent permeability barriers and deactivation processes associated with bacteria. Herein, we report covalent attachment normally Gram-positive-only antibiotic,...
Assimilation of iron is essential for microbial growth. Most microbes synthesize and excrete low molecular weight chelators called siderophores to sequester deliver by active transport processes. Specific outer membrane proteins recognize, bind initiate species-selective ferric siderophore complexes. Organisms most often have specific receptors multiple types siderophores, presumably ensure adequate acquisition the that their Conjugation drugs synthetic hydroxamate or catechol components can...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTEfficient Synthesis of a Stereochemically Defined Carbohydrate Scaffold: Carboxymethyl 2-Acetamido-6-Azido- 4-O-Benzyl-2-deoxy-α-d-GlucopyranosideManuka Ghosh, Richard G. Dulina, Ramesh Kakarla, and Michael J. SofiaView Author Information Intercardia Research Laboratories, 8 Cedar Brook Drive, Cranbury, New Jersey 08852 [email protected]Cite this: Org. Chem. 2000, 65, 24, 8387–8390Publication Date (Web):October 28, 2000Publication History Received4...
The first antibiotic conjugates of vancomycin (1) and siderophore analogues containing spermidine-based catechol ligands (conjugate 11) as well mixed hydroxamate 13) are described. design the was based on earlier observation that conjugation components to β-lactam antibiotics induced active iron transport-mediated drug delivery. novel (11 were synthesized by selective acylation primary amino group 1. Preliminary biological studies indicated modified vancomycins lost some activity (4-...
Siderophores selectively bind ferric iron and are involved in receptor-specific transport into bacteria. Several types of siderophores were synthesized, growth-promoting or inhibitory activities when they conjugated to carbacephalosporin, erythromycylamine, nalidixic acid investigated. Overall, 11 21 drug conjugates tested against seven different bacterial species: Escherichia coli, Bordetella bronchiseptica, Pasteurella multocida, haemolytica, Streptococcus suis, Staphylococcus aureus,...
Selective whole-cell <italic>Acinetobacter baumannii</italic> detection using a biotinylated siderophore–Fe(<sc>iii</sc>) complex in localized surface plasmon resonance biosensing platform.
The syntheses and preliminary biological evaluation of conjugates a synthetic isocyanurate-based trihydroxamate siderophore with two antifungal agents, 5-FU (conjugate 9) norneoenactin 12), macrolide antibiotic, erythromycylamine 18), are described. A 19 F NMR study was used to determine the hydrolytic stability conjugate 9 under assay conditions. Preliminary studies ferric complexes 12 indicated that these agents recognized by Candida perhaps actively transported into cell...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIron Transport-Mediated Drug Delivery: Synthesis and Biological Evaluation of Cyanuric Acid-Based Siderophore Analogs .beta.-Lactam ConjugatesManuka Ghosh Marvin J. MillerCite this: Org. Chem. 1994, 59, 5, 1020–1026Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/jo00084a018https://doi.org/10.1021/jo00084a018research-articleACS PublicationsRequest...
Siderophores produced in soil by plant growth-promoting rhizobacteria (PGPRs) play several roles, including nutrient mobilizers and can be useful as plants defense elicitors. We investigated the role of a synthetic mixed ligand bis-catechol-mono-hydroxamate siderophore (SID) that mimics chemical structure natural siderophore, fimsbactin, Acinetobacter spp. resistance against phytopathogen Pseudomonas syringaepv tomato DC3000 (Pst DC3000), Arabidopsis thaliana. first tested antibacterial...
Synthesis and in vitro activity of two novel conjugates (4 5) desferrioxamine B, with nalidixic acid (2) anthraquinone carboxylic (3), are described.
The synthesis of the bicyclic oxamazin 23 was accomplished by an intramolecular cyclization process. Allyl protected N-hydroxy β-lactam 22 served as key intermediate during a simultaneous deprotection and in presence Pd(0).
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”