A5101545142- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Melanoma and MAPK Pathways
- Advanced Optical Imaging Technologies
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Digital Holography and Microscopy
- CRISPR and Genetic Engineering
- Asymmetric Synthesis and Catalysis
- Cell death mechanisms and regulation
- Carbon and Quantum Dots Applications
- Advanced Biosensing Techniques and Applications
- Photonic Crystals and Applications
- Advanced Fluorescence Microscopy Techniques
- Synthetic Organic Chemistry Methods
- Photonic and Optical Devices
- Optical Coatings and Gratings
- Chromosomal and Genetic Variations
- Virtual Reality Applications and Impacts
- Natural product bioactivities and synthesis
- Monoclonal and Polyclonal Antibodies Research
- Hydrogels: synthesis, properties, applications
Sun Yat-sen University
2021-2024
State Grid Corporation of China (China)
2023
Yale University
2015-2022
Second Affiliated Hospital of Shantou University Medical College
2022
Shantou University
2022
Fujian Agriculture and Forestry University
2018
Nankai University
2010-2017
The University of Texas MD Anderson Cancer Center
2012
University of Alberta
2012
Due to its simplicity, versatility, and high efficiency, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology has emerged as one of most promising approaches for treatment a variety genetic diseases, including human cancers. However, further translation CRISPR/Cas9 cancer gene therapy requires development safe efficient, highly specific delivery both Cas9 single guide RNA tumors. Here, novel core-shell nanostructure, liposome-templated hydrogel nanoparticles...
Abstract Integral imaging (II) display, one of the most critical true-3D display technologies, has received increasing research recently. Significantly, an achromatic metalens array realized a broadband metalens-array-based II (meta-II). However, past micro-scale arrays were incompatible with commercial micro-displays; furthermore, elemental image (EIA) rendering is always slow. The two hinders in device and algorithm prevent meta-II from being used for practical video-rate near-eye displays...
Stroke is the leading cause of death and disability. Currently, there no effective pharmacological treatment for this disease, which can be partially attributed to inability efficiently deliver therapeutics brain. Here we report development natural compound-derived nanoparticles (NPs), function both as a potent therapeutic agent stroke an efficient carrier drug delivery ischemic First, screened collection nanomaterials identified betulinic acid (BA) one most antioxidants treatment. Next,...
Stroke is a deadly disease without effective pharmacotherapies, which due to two major reasons.First, most therapeutics cannot efficiently penetrate the brain.Second, single agent pharmacotherapy may be insufficient and treatment of stroke requires targeting multiple complementary targets.Here, we set develop component, multifunctional nanoparticles (NPs) for targeted delivery glyburide brain treatment. Methods:To characterize penetrability, radiolabeled glyburide, intravenously administered...
Breast cancer is the most common type of in women. About 12% all women United States will be diagnosed with breast over their lifetimes. At same time, incidences brain metastases (BMs) are increasing and represent an emerging health threat. However, there no effective chemotherapy for (BCBMs), which largely due to lack efficient delivery antitumor drugs or drug combinations brain. In this study, oleanolic acid (OA), a natural pentacyclic triterpenoid compound excellent activity, was found...
Clinical translation of therapeutic peptides, particularly those that require penetration the cell membrane or are cytolytic, is a major challenge. A novel approach based on complementary mechanism, which has been widely used for guided synthesis DNA RNA nanoparticles, de novo design activatable protein nanoparticles (APNPs) targeted delivery peptides described. APNPs formed through self-assembly three independent polypeptides pairwise coiled-coil dimerization. They capable long circulation...
// Daniel I. Jacobs 1 , Qin 1, 2 Alan Fu 3 Zeming Chen 4 Jiangbing Zhou 4, 5 and Yong Zhu Department of Environmental Health Sciences, Yale School Public Health, New Haven, CT, USA Current address: Division Genetic Molecular Toxicology, National Center for Toxicological Research, Food Drug Administration, Jefferson, AR, Address: Epidemiology, UCLA Fielding Los Angeles, CA, Neurosurgery, Medicine, Biomedical Engineering, University, Correspondence to: Zhu, email: yong.zhu@yale.edu Keywords:...
High performance and cost-effective solar absorbers are crucial for various optical applications, such as collection thermophotovoltaic devices. This study designs experimentally demonstrates a wide-angle broadband absorber. The proposed absorber is composed of tapered polyimide substrate Al-Cr-SiO 2 -Cr-SiO thin-film based on the interference multilayer thin film excited magnetic resonance light-trapping structures. composite process colloidal lithography method magnetron sputtering...
Abstract Glioblastoma (GBM) is a deadly disease without effective treatment. Because glioblastoma stem cells (GSCs) contribute to tumor resistance and recurrence, improved treatment of GBM can be achieved by eliminating GSCs through inducing their differentiation. Prior efforts have been focused on studying GSC differentiation towards the astroglial lineage. However, regulation neuronal oligodendroglial lineages largely unknown. To identify genes that control all three lineages, we performed...
Abstract Breast cancer brain metastases (BCBMs) represent a major cause of morbidity and mortality among patients with breast cancer. Chemotherapy, which is widely used to treat tumors outside the brain, often ineffective on BCBMs due its inability efficiently cross blood‐brain barrier (BBB). Although BBB partially disrupted in tumor lesions, it remains intact enough prevent most therapeutics from entering brain. Here, nanotechnology approach reported that can overcome through synthesis...
Abstract Breast cancer brain metastases (BCBM) is a devastating disease with dismal prognosis. Although chemotherapy widely used for clinical management of most tumors, it often ineffective BCBM. Therefore, alternative approaches improved treatment BCBM are in great demand. Here, an innovative gene therapy regimen reported that designed effective First, poly(lactone‐ co ‐β‐amino ester) nanoparticles capable efficient delivery synthesized and engineered targeted to through surface conjugation...
Microendoscopes are vital for disease detection and clinical diagnosis. The essential issue microendoscopes is to achieve minimally invasive high-resolution observations of soft tissue structures inside deep body cavities. Obviously, the microscope objective a must with capabilities both high lateral resolution in wide field view (FOV) miniaturization size. Here, we propose meta-objective, i.e., based on cascaded metalenses. two metalenses, optical diameters 400 μm 180 μm, respectively,...
Abstract: Macrophages play important roles in the pathogenesis of various diseases, and are potential therapeutic targets. Furthermore, macrophages key antigen-presenting cells vaccine design. In this study, we report on novel formulation (bovine serum albumin [BSA]-loaded glucan particles [GMP-BSA]) based β-glucan from cell walls baker's yeast for targeted delivery protein to macrophages. Using formulation, chitosan, tripolyphosphate, alginate were used fabricate colloidal with model BSA...
EMMPRIN, a cell adhesion molecule highly expressed in variety of tumors, is associated with poor prognosis cancer patients. Mechanistically, EMMPRIN has been characterized to contribute tumor development and progression by controlling the expression MMPs VEGF. In present study, using fluorescently labeled bone marrow-derived cells (BMDCs), we found that down-regulation reduces growth metastasis, reduced recruitment BMDCs. Further protein profiling studies suggest controls BMDC through...
Background: Capsaicin, the hot pepper agent, produces burning followed by desensitization. To treat localized itch or pain with minimal burning, low capsaicin concentrations can be repeatedly applied. We hypothesized that alternatively controlled release of from poly(lactic-co-glycolic acid) (PLGA) nanoparticles desensitizes superficially terminating nociceptors, reducing burning. Methods: Capsaicin-loaded PLGA were prepared (single-emulsion solvent evaporation) and characterized (size,...
A newly designed, dual-functional probe based on intracellular activation has been successfully developed for the detection of cancer cells.
Strategies to target nanoparticles tumors that rely on surface modification with ligands bind molecules overexpressed cancer cells or the tumor neovasculature suffer from a major limitation: delivery of toxic agents amount available for targeting decreases time; consequently, efficiency nanoparticle is reduced. To overcome this limitation, here we propose an autocatalytic tumor-targeting mechanism based extracellular DNA (exDNA). exDNA enriched in microenviroment and increases treatment...
Flower and fruit colors are of vital importance to the ecology economic market value plants. The mechanisms flower coloration have been well studied, especially among ornamental plants cultivated fruits. As people pay more attention exocarp coloration, endocarp in some species has often ignored. Here, we report on molecular mechanism three development stages Euscaphis konishii. results show that reddening is closely related anthocyanin accumulation, a total 86,120 unigenes were assembled,...