A5038087692- Peroxisome Proliferator-Activated Receptors
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Numerical methods for differential equations
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Advanced biosensing and bioanalysis techniques
- Supercapacitor Materials and Fabrication
- Black Holes and Theoretical Physics
- Lanthanide and Transition Metal Complexes
- Pulsars and Gravitational Waves Research
- Astrophysical Phenomena and Observations
- RNA Interference and Gene Delivery
- Fiber-reinforced polymer composites
- Luminescence and Fluorescent Materials
- Quantum Dots Synthesis And Properties
- Carbon and Quantum Dots Applications
- Graphene research and applications
- Gout, Hyperuricemia, Uric Acid
- Ruminant Nutrition and Digestive Physiology
- Polymer Surface Interaction Studies
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory mediators and NSAID effects
- Nanocluster Synthesis and Applications
Zhejiang University
2022-2025
Donghua University
2022-2025
Jinhua Academy of Agricultural Sciences
2024-2025
Shanghai Liangyou (China)
2025
Xi'an Polytechnic University
2025
The University of Texas MD Anderson Cancer Center
2017-2024
South China University of Technology
2022-2024
Lanzhou University
2020-2024
Chongqing Medical University
2021-2024
Dalian Medical University
2021-2024
Abstract An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from body within reasonable timescale. However, integration diagnostic and therapeutic components into single nanoparticle remains challenging. In this study, pH-activated nanodots (termed Fe-CPNDs) composed coordination polymers were synthesized via simple scalable method based on reactions among Fe 3+ , gallic acid poly(vinylpyrrolidone) at ambient conditions. The Fe-CPNDs exhibited...
Due to its simplicity, versatility, and high efficiency, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology has emerged as one of most promising approaches for treatment a variety genetic diseases, including human cancers. However, further translation CRISPR/Cas9 cancer gene therapy requires development safe efficient, highly specific delivery both Cas9 single guide RNA tumors. Here, novel core-shell nanostructure, liposome-templated hydrogel nanoparticles...
Abstract High value utilization of renewable biomass materials is great significance to the sustainable development human beings. For example, because contains large amounts carbon, they are ideal candidates for preparation carbon nanotube fibers. However, continuous such fibers using as source remains a huge challenge due complex chemical structure precursors. Here, we realize high-performance from lignin by solvent dispersion, high-temperature pyrolysis, catalytic synthesis, and assembly....
Drug discovery and development affects various aspects of human health dramatically impacts the pharmaceutical market. However, investments in a new drug often go unrewarded due to long complex process research (R&D). With advancement experimental technology computer hardware, artificial intelligence (AI) has recently emerged as leading tool analyzing abundant high-dimensional data. Explosive growth size biomedical data provides advantages applying AI all stages R&D. Driven by big...
Abstract Traumatic brain injuries (TBI) and stroke are major causes of morbidity mortality in both developing developed countries. The complex heterogeneous pathophysiology TBI cerebral ischemia‐reperfusion injury (CIRI), addition to the blood‐brain barrier (BBB) resistance, is a advancement diagnostics therapeutics. Clinical data showed that severity positively correlated with number neutrophils peripheral blood sites. Furthermore, neutrophil extracellular traps (NETs) released by correlate...
The development of biosafe nanoplatforms with diagnostic and therapeutic multifunction is extremely demanded for designing cancer theranostic medicines. Here, a facile methodology developed to construct multifunctional nanotheranostic that gathers five functions, upconversion luminescence (UCL) imaging, T 1 ‐weighted magnetic resonance imaging (MRI), X‐ray computed tomography (CT) photothermal therapy (PTT), chemotherapy, into one single nanoprobe (named as UCNP@PDA 5 ‐PEG‐DOX). For...
Abstract Cell membrane coating has recently emerged as a promising biomimetic approach to engineering nanoparticles (NPs) for targeted drug delivery. However, simple cell may not meet the need efficient delivery brain. Here, novel molecular strategy modify surface of NPs with enhanced brain penetration is reported. By using poly(lactic‐ co ‐glycolic) acid model, it shown that ischemic through neural stem cells (NSCs), and efficiency can be further increased isolated from NSCs engineered...
Current treatments for ischemic stroke are insufficient. The lack of effective pharmacological approaches can be mainly attributed to the difficulty in overcoming blood–brain barrier. Here, we report a simple strategy synthesize protease-responsive, brain-targeting nanoparticles improved treatment stroke. resulting respond proteases enriched microenvironment, including thrombin or matrix metalloproteinase-9, by shrinking expanding their size. Targeted delivery was achieved using surface...
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate tumorigenesis; PanINs rarely progress to PDAC. Critical factors promote this progression, especially targetable ones, remain poorly defined. We show peroxisome proliferator-activated receptor-delta (PPARδ), lipid nuclear receptor, upregulated...
Microneedles (MNs) have become versatile platforms for minimally invasive transdermal drug delivery devices. However, there are concerns about MN-induced skin infections with long-term administration. Using the Langmuir-Blodgett (LB) technique, a simple method depositing antibacterial nanoparticles of various shapes, sizes, and compositions onto MNs is developed. This strategy has merits over conventional dip coating techniques, including controlled layers, uniform high coverage,...
Abstract Lithium–sulfur (Li–S) batteries can potentially outperform state-of-the-art lithium-ion batteries, but their further development is hindered by challenges, such as poor electrical conductivity of sulfur and lithium sulfide, shuttle phenomena polysulfides, uneven distribution solid reaction products. Herein, free-standing carbon nanofibers embedded with oxygen-deficient titanium dioxide nanoparticles (TiO 2-x /CNFs) has been fabricated a facile electrospinning method, which support...
Abstract Toll‐like receptor 7/8 agonists, such as imidazoquinolines (IMDQs), are promising for the de novo priming of antitumor immunity. However, their systemic administration is severely limited due to off‐target toxicity. Here, this work describes a sequential drug delivery strategy. The formulation composed two modules: tumor microenvironment remodeling nanocarrier (poly( l ‐glutamic acid)‐ graft‐ methoxy poly(ethylene glycol)/combretastatin A4, termed CA4‐NPs) and an immunotherapy...
Familiar clustering of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) has been frequently reported. However, limited information is available about the underlying molecular mechanisms in HBV-related HCC patients with family history HCC. In our previous study, Agilent miRNA Base 16.0 microarray showed profiles plasma who had a This study aims to explore expression, function, and miR-3188 that might provide novel insights into role on risk The expression levels were markedly...
Polydopamine nanoparticles (PDA NPs) which combine diagnostic and therapeutic functions are potentially useful in biomedicine. However, it is difficult to synthesize PDA NPs of a relatively small size (≤50 nm diameter) using the traditional polymerization dopamine monomers an alkaline water-ethanol solution at room temperature. Herein, with average diameters ranging from 25 43 prepared way similar silica-like reverse microemulsion process. The can be modulated by changing amount...
Stroke is a deadly disease without effective pharmacotherapies, which due to two major reasons.First, most therapeutics cannot efficiently penetrate the brain.Second, single agent pharmacotherapy may be insufficient and treatment of stroke requires targeting multiple complementary targets.Here, we set develop component, multifunctional nanoparticles (NPs) for targeted delivery glyburide brain treatment. Methods:To characterize penetrability, radiolabeled glyburide, intravenously administered...
Abstract Symplectic integrators that preserve the geometric structure of Hamiltonian flows and do not exhibit secular growth in energy errors are suitable for long-term integration N -body systems solar system. However, construction explicit symplectic is frequently difficult general relativity because all variables inseparable. Moreover, even if two analytically integrable splitting parts exist a relativistic Hamiltonian, analytical solutions functions proper time. Naturally, implicit...
Lignin is an abundant natural polymer and a green biomass precursor containing over 60% carbon. However, high-value sustainable material production from lignin remains underutilized. Here, flexible carbon nanotube (CNT) film continuously fabricated via floating catalyst chemical vapor deposition (FCCVD) using as the source. The as-prepared CNT exhibits high conductivity (4.19 × 104 S m–1) can directly serve electrode without further processing. Moreover, adaptable displays strong mechanical...