Abstract An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from body within reasonable timescale. However, integration diagnostic and therapeutic components into single nanoparticle remains challenging. In this study, pH-activated nanodots (termed Fe-CPNDs) composed coordination polymers were synthesized via simple scalable method based on reactions among Fe 3+ , gallic acid poly(vinylpyrrolidone) at ambient conditions. The Fe-CPNDs exhibited...

The development of biosafe nanoplatforms with diagnostic and therapeutic multifunction is extremely demanded for designing cancer theranostic medicines. Here, a facile methodology developed to construct multifunctional nanotheranostic that gathers five functions, upconversion luminescence (UCL) imaging, T 1 ‐weighted magnetic resonance imaging (MRI), X‐ray computed tomography (CT) photothermal therapy (PTT), chemotherapy, into one single nanoprobe (named as UCNP@PDA 5 ‐PEG‐DOX). For...

Methylammonium lead tribromide perovskite single crystals have been demonstrated to be good candidates as sensitive X-ray detectors in direct detection mode recent years. However, its performance based on the orientation of different facets is still not clear. Here, we developed a facile strategy chemically expose [110] facet from low-cost solution processes by tailoring nonstoichiometry feeding ions selectively suppress growth [100] facet. In contrast physically cutting and sawing...

2D perovskite single crystals have emerged as excellent optoelectronic materials owing to their unique anisotropic properties. However, growing large remains challenging and time-consuming. Here, a new composition of lead-free perovskite-4-fluorophenethylammonium bismuth iodide [(F-PEA)3 BiI6 ] is reported. An oriented bulk wafer with area 1.33 cm2 obtained by tableting disordered powders, resulting in resistivities 5 × 1010 2 1011 Ω cm the lateral vertical directions, respectively....

Abstract Halide perovskites exhibit diverse properties depending on their compositions. However, integrating desired into one material is still challenging. Here, a facile solution‐processed epitaxial growth method to grow 2D perovskite single crystal top of 3D crystal, which can passivate the surface defects for improved device performance reported. Short formamidine (FA + ) ions are replaced by long organic cations, fully align and cover prevent migration or short FA volatilization. The...

Polydopamine nanoparticles (PDA NPs) which combine diagnostic and therapeutic functions are potentially useful in biomedicine. However, it is difficult to synthesize PDA NPs of a relatively small size (≤50 nm diameter) using the traditional polymerization dopamine monomers an alkaline water-ethanol solution at room temperature. Herein, with average diameters ranging from 25 43 prepared way similar silica-like reverse microemulsion process. The can be modulated by changing amount...

A significant barrier to organ transplantation is the cellular rejection that occurs and mediated by antibodies, T cells, innate immune cells. This study was aimed determine number of CD4(+)CD25(+)Foxp3(+) Treg, CD4(+)IFN-γ(-)IL-17(+) Th17, CD4(+)IFN-γ(+)IL-17(-) Th1 CD4(+)IFN-γ(+)IL-17(+) Th1/17 cells in renal transplant recipients (RTR).Renal performed for a total 35 patients with end-stage failure. The serum level IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17 were measured pre-...

Objective: To explore a new predictive model of lymphatic vascular infiltration (LVI) in rectal cancer based on magnetic resonance (MR) and computed tomography (CT). Methods: A retrospective study was conducted 94 patients with histologically confirmed cancer, they were randomly divided into training cohort (n = 65) validation 29). All underwent MR CT examination within 2 weeks before treatment. On each slice the tumor, we delineated volume interest T2-weighted imaging, diffusion weighted...

Abstract Metal halide perovskite scintillators encounter unprecedented opportunities in indirect ionizing radiation detection due to their high quantum yields. However, the long scintillation lifetime of microseconds upon irradiation, known as afterglow phenomenon, obviously limits fast development. Here, a new type hybrid X‐ray detector wafer combining direct methylamine lead iodide (MAPbI 3 ) semiconductor and zero‐dimensional cesium copper (Cs Cu 2 I 5 scintillator through low‐cost...

Here, we report the covalent conjugation of lectin on Fe2O3@Au core@shell nanoparticle (lectin–Fe2O3@Au NP) for T2-weighted magnetic resonance (MR) and X-ray computed tomography (CT) dual-modality imaging. The lectin–Fe2O3@Au NPs are prepared by coupling lectins to NP surfaces through bifunctional PEG NHS ester disulfide (NHS-PEG-S-S-PEG-NHS) linkers. After nonspecific adsorption sites surface blocked thiolated (PEG-SH), exhibit excellent stability in biological medium inappreciable...

<bold>5BMF</bold>is a new fluorescent mitochondria-accumulating delocalized lipophilic cations [DLC] that boasts significantly increased anti-cancer effects and low toxicity in comparison to previous DLCs, addressing current hurdles DLC clinical translation.

This article aims to develop and assess the radiomics paradigm for predicting colorectal cancer liver metastasis (CRLM) from primary tumor.This retrospective study included 100 patients First Hospital of Jilin University June 2017 December 2017. The comprised 50 with without CRLM. maximum-level enhanced computed tomography (CT) image in portal venous phase each patient was selected as original data. To automatically implement radiomics-related paradigms, we developed a toolkit called...

Abstract Background The detection of Kirsten rat sarcoma viral oncogene homolog (KRAS) gene mutations in colorectal cancer (CRC) is key to the optimal design individualized therapeutic strategies. noninvasive prediction KRAS status CRC challenging. Deep learning (DL) medical imaging has shown its high performance diagnosis, classification, and recent years. In this paper, we investigated predictive by using a DL method with residual neural network (ResNet) estimate mutation patients based on...

To develop and validate a multiregional-based magnetic resonance imaging (MRI) radiomics model combine it with clinical data for individual preoperative prediction of lymph node (LN) metastasis in rectal cancer patients.186 adenocarcinoma patients from our retrospective study cohort were randomly selected as the training (n = 123) testing cohorts 63). Spearman's rank correlation coefficient least absolute shrinkage selection operator used feature dimensionality reduction. Five support vector...

Abstract Objectives To develop and validate a PET/CT nomogram for preoperative estimation of lymph node (LN) staging in patients with non-small cell lung cancer (NSCLC). Methods A total 263 pathologically confirmed LNs from 124 NCSLC were retrospectively analyzed. Positron-emission tomography/computed tomography (PET/CT) examination was performed before treatment according to the clinical schedule. In training cohort ( N = 185), malignancy-related features, such as SUVmax, short-axis...

Perineural invasion (PNI) as a grossly underreported independent risk predictor in rectal cancer is hard to identify preoperatively. We aim predict PNI status using multi-modality radiomics. In total, 396 radiomics features were extracted from T2-weighted images (T2WIs), diffusion-weighted (DWIs), and portal venous phase of contrast-enhanced CT (CE-CT) respectively 94 consecutive patients with histologically confirmed cancer. T2WI score, DWI score calculated via the selection optimization....

Abstract Both semiconductors and scintillators have their own advantages in direct indirect X‐ray detection, respectively. However, they are also limited by intrinsic properties detection mechanisms. Here, a low‐cost large‐area flat detector is reported combining cesium silver bismuth bromide (Cs 2 AgBiBr 6 ) perovskite semiconductor with ethylenebis‐triphenylphosphonium manganese (II) ((C 38 H 34 P )MnBr 4 scintillator through fast tableting processes. Cs (C can attenuate the photons to...