A5075808008- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Liver Diseases and Immunity
- SARS-CoV-2 and COVID-19 Research
- Fibroblast Growth Factor Research
- Pancreatitis Pathology and Treatment
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Kruppel-like factors research
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
First Bethune Hospital of Jilin University
2011-2024
Yahoo (United Kingdom)
2023-2024
Health Commission of Jilin Province
2024
Committee on Publication Ethics
2024
Model Animal Research Center
2020-2023
Eastern Hepatobiliary Surgery Hospital
2022
Second Military Medical University
2022
Jilin Medical University
2022
<b><i>Background:</i></b> Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the fourth most common malignancy and second leading cause of tumor-related death, thereby posing a significant threat to life health Chinese people. <b><i>Summary:</i></b> Since publication <i>Guidelines for Diagnosis Treatment Liver Cancer (2017 Edition)</i> 2018, additional high-quality evidence has emerged with relevance...
<b><i>Background:</i></b> Hepatocellular carcinoma (HCC) (about 85–90% of primary liver cancer) is particularly prevalent in China because the high prevalence chronic hepatitis B infection. HCC fourth most common malignancy and third leading cause tumor-related deaths China. It poses a significant threat to life health Chinese people. <b><i>Summary:</i></b> This guideline presents official recommendations National Health Family Planning...
Primary liver cancer, of which around 75-85% is hepatocellular carcinoma in China, the fourth most common malignancy and second leading cause tumor-related death, thereby posing a significant threat to life health Chinese people.Since publication Guidelines for Diagnosis Treatment Liver Cancer China June 2017, were updated by National Health Commission December 2019, additional high-quality evidence has emerged from researchers worldwide regarding diagnosis, staging, treatment that requires...
Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk morbidity and mortality. Seriously affected individuals manifest disorders hemostasis cytokine storm, it is not understood how these manifestations severe COVID-19 are linked. Here, we showed that SARS-CoV-2 spike protein engaged CD42b receptor activate platelets via 2 distinct signaling pathways promoted platelet-monocyte communication through engagement P...
Objective Different serum lipids and lipid-modifying targets should affect the risk of cholelithiasis differently, however, whether such effects are causal is still controversial we aimed to answer this question. Design We prospectively estimated associations four with in UK Biobank using Cox proportional hazard model, including total cholesterol (TC), low-density lipoprotein (LDL-C), high-density (HDL-C) triglycerides (TG). Furthermore, genetically predicted Europeans Mendelian...
Hepatocellular carcinoma (HCC) is a prevalent malignancy worldwide, ranking as the sixth most common and third leading cause of cancer-related mortality. Late diagnosis, limited management options, its complex etiology contribute to poor prognosis high mortality rates. Recent advances in understanding molecular mechanisms HCC innovations high-throughput sequencing technologies have led development diagnostics personalized therapies for this challenging malignancy. This review provides...
Abstract Kupffer cells are liver resident macrophages and play critical role in fatty disease, yet the underlying mechanisms remain unclear. Here, we show that activation of G-protein coupled receptor 3 (GPR3) stimulates glycolysis protects mice from obesity disease. GPR3 induces a rapid increase via formation complexes between β-arrestin2 key glycolytic enzymes as well sustained through transcription genes. In mice, results enhanced glycolysis, reduced inflammation inhibition high-fat diet...
Objective The correlation between cholangiocarcinoma (CCA) progression and bile is rarely studied. Here, we aimed to identify differential metabolites in benign malignant ducts elucidate the generation, function degradation of metabolites. Design Differential from CCA biliary stenosis were identified by metabonomics. Biliary molecules able induce mast cell (MC) degranulation revealed vitro vivo experiments, including liquid chromatography-mass spectrometry (MS)/MS bioluminescence resonance...
A significant barrier to organ transplantation is the cellular rejection that occurs and mediated by antibodies, T cells, innate immune cells. This study was aimed determine number of CD4(+)CD25(+)Foxp3(+) Treg, CD4(+)IFN-γ(-)IL-17(+) Th17, CD4(+)IFN-γ(+)IL-17(-) Th1 CD4(+)IFN-γ(+)IL-17(+) Th1/17 cells in renal transplant recipients (RTR).Renal performed for a total 35 patients with end-stage failure. The serum level IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17 were measured pre-...
The effectiveness of adjuvant immunotherapy to diminish recurrence and improve long-term prognosis following curative-intent surgical resection for hepatocellular carcinoma (HCC) is increased interest, especially among individuals at high risk recurrence. objective the current study was investigate impact on survival after curative patients with intermediate/advanced HCC. Using a prospectively-collected multicenter database, who underwent Barcelona Clinic Liver Cancer (BCLC) stage B/C HCC...
Abstract OBJECTIVES Tracheal reconstruction post-extensive resection remains an unresolved challenge in thoracic surgery. This study evaluates the use of aortic allografts (AAs) for tracheal replacement and a rat model, aiming to elucidate underlying mechanisms regeneration. METHODS AAs from female rats were employed 36 male rats, with exceeding half length. To avert collapse, silicone stents inserted into AA lumens. No immunosuppressive therapy was administered. The euthanized biweekly,...
Coronavirus disease 2019 (COVID-19) is a current global health threat caused by SARS-CoV-2. The innate immune response such as type I IFN (IFN-I) the first line of host defense against viral infections, whereas SARS-CoV-2 proteins antagonize IFN-I production through distinct mechanisms.
Abstract Previous studies on the molecular classification of cholangiocarcinoma (CCA) focused certain anatomical sites, and disregarded tissue contamination biases in transcriptomic profiles. We aim to provide universal scheme prognostic biomarker CCAs across locations. Comprehensive bioinformatics analysis is performed data from 438 CCA cases various After excluding tumors showing normal expression patterns, we identify two subtypes subtypes, explore molecular, clinical, microenvironmental...