The development of biosafe nanoplatforms with diagnostic and therapeutic multifunction is extremely demanded for designing cancer theranostic medicines. Here, a facile methodology developed to construct multifunctional nanotheranostic that gathers five functions, upconversion luminescence (UCL) imaging, T 1 ‐weighted magnetic resonance imaging (MRI), X‐ray computed tomography (CT) photothermal therapy (PTT), chemotherapy, into one single nanoprobe (named as UCNP@PDA 5 ‐PEG‐DOX). For...

In this paper, we propose a new approach for face shape recovery from single image. A near infrared (NIR) image is used as the input, and mapping NIR tensor space to 3D space, learned by using statistical learning, recovery. learning phase, two models are constructed images respectively, canonical correlation analysis (CCA) based multi-variate faces given training set of NIR-3D pairs. reconstruction an image, depth map computed directly with help models. Experimental results provided...

Polybrominated diphenyl ethers (PBDEs) are widely distributed persistent organic pollutants. In vitro and in vivo research using various animal models have shown that PBDEs might be transformed to hydroxylated PBDEs, but there few studies on metabolism of by intact whole plants. this research, pumpkin plants (Cucurbita maxima × C. moschata) were hydroponically exposed 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47). A debromination product (BDE-28) four metabolites (5-OH-BDE-47, 6-OH-BDE-47,...

A growing number of studies have demonstrated the importance marital quality among patients undergoing medical procedures. The aim study was to expand literature by examining relationships between stress, social support and family marriage life hemodialysis patients. total 114 participants, including 38 their spouses healthy controls, completed a survey package assessing support, functioning satisfaction quality. We found that were less flexible in adaptability compared with controls....

We developed a three-dimensional (3D) polymer-brush substrate for protein and peptide microarray fabrication, this was facilely prepared by copolymerization of glycidyl methacrylate (GMA) 2-hydroxyethyl (HEMA) monomers via surface-initiated atom transfer radical polymerization (SI-ATRP) on glass slide. The performance obtained poly(glycidyl methacrylate-co-2-hydroxyethyl methacrylate) (P(GMA-HEMA)) brush assessed binding human IgG with rabbit antihuman antibodies the determination matrix...

Transposons are mobile and ubiquitous DNA molecules that can cause vast genomic alterations. In plants, it is well documented transposon mobilization strongly repressed by methylation; however, its regulation at the posttranscriptional level remains relatively uninvestigated. Here, we suggest RNA marked m 6 A methylation be localized in stress granules (SGs). Intriguingly, SG-localized AtALKBH9B selectively demethylates a heat-activated retroelement, Onsen , thereby releases from spatial...

This paper presents a novel discriminative method for estimating 3D shape from single image with Morphable Model (3DMM). Until now, most traditional 3DMM fitting methods depend on the analysis-by-synthesis framework which searches best parameters by minimizing difference between input and model appearance. They are highly sensitive to initialization have rely stochastic optimization handle local minimum problem, is usually time-consuming process. To solve we find different direction estimate...

Bone marrow mesenchymal stem cells (BMMSCs) are used in cardiac tissue engineering for the regeneration of diseased hearts. We examined differentiation rat BMMSCs into cardiomyocyte-like when induced with a combined low dose treatment transforming growth factor-β1 (TGF-β1) and 5-azacytidine (5-AZA). Results showed that cell proliferation group TGF-β1 5-AZA was increased compared or group. The apoptosis relieved by to alone. number positive myosin heavy chain, connexin-43, α-actin, troponin I...

Aim: Basic fibroblast growth factor (bFGF) increases the migration and viability of bone marrow mesenchymal stem cells (MSCs) in vitro.Retrograde coronary venous infusion can provide both increased regional bFGF concentrations homogeneous cell dissemination.We determined whether retrograde delivery enhances potency transplanted MSCs for cardiac repair a canine infarct model.Methods Results: Under hypoxic conditions, cellular was significantly co-cultured with compared to vascular endothelial...

Matrix metalloproteinases (MMPs) are closely associated with cancer cell invasion and metastasis. Herein, a fluorescence resonance energy transfer (FRET)-peptide microarray-based metal enhanced (MEF) assay is proposed for multiple sensitive profiling of MMPs activities on novel Au/Ag@SiO2 substrate. The substrate prepared by electroless deposition silver gold nanoparticle (GNP) seeds, followed SiO2 shell coating surface functionalization. specific FRET peptides spotted the to sensitively...

Graphene-based magnetic and plasmonic nanocomposites (DOX–rGO–Fe₂O₃@Au NPs) have been prepared for magnetic-field-assisted drug delivery chemo-photothermal synergistic therapy.

Open AccessCCS ChemistryRESEARCH ARTICLE1 Mar 2021Twisted Intramolecular Charge Transfer—Aggregation-Induced Emission Fluorogen with Polymer Encapsulation-Enhanced Near-Infrared for Bioimaging Lingchen Meng†, Xibo Ma†, Shan Jiang, Song Zhang, Zhiyuan Wu, Bin Xu, Zhen Lei, Leijing Liu and Wenjing Tian Meng† State Key Laboratory of Supramolecular Structure Materials, Department Chemistry, Jilin University, Changchun 130012 , Ma† CBSR&NLPR, Institute Automation, Chinese Academy Sciences,...

Local binary pattern (LBP) and its variants are effective descriptors for face recognition. The traditional LBP like features extracted based on the original pixel or patch values of images. In this paper, we propose to learn discriminative image filter improve discriminant power feature. basic idea is after filtering with learned filter, difference vectors (PDVs) between images from same person consistent different persons enlarged. way, filtered considered be more than those Moreover, a...

Colorectal cancer is one of the most common cancers worldwide in terms both incidence and mortality. The associations expressions tissue plasma miR-29b were not detected this study.There are 400 healthy age- gender-matched controls enrolled study a rate 1:2. receiver operating characteristic curve analysis was undertaken using expression level for colorectal specimens from patients with to assess diagnostic accuracy levels.It found that associated miR-29b. Advanced showed aberrant tissues...

The phosphorylation of nucleic acid with 5′-OH termini catalyzed by polynucleotide kinase (PNK) involves several significant cellular events. Here a paper-based fluorescence assay λ exonuclease assistance was reported for facile detection PNK activity through monitoring the change intensity on paper surface. Cy5-labeled ssDNA first immobilized surface aldehyde group modified paper, and BHQ-labeled then employed to quench help an adaptor ssDNA. When cleavage reaction were introduced,...

Abstract Acute‐on‐chronic liver failure ( ACLF ) is the most common type of and associated with grave consequences. Systemic inflammation has been linked to its pathogenesis outcome, but identifiable triggers are absent. Recently, extracellular histones, especially H4, have recognized as important mediators cell damage in various inflammatory conditions. This study aimed investigate whether histones clinical implications patients hepatitis B virus HBV )‐related . One hundred twelve ‐related...

Eye localization is an important part in face recognition system, because its precision closely affects the performance of recognition. Although various methods have already achieved high on images with quality, their will drop low quality images. In this paper, we propose a robust eye method for to improve detection rate and precision. First, probabilistic cascade (P-Cascade) framework, which reformulate traditional classifier way. The P-Cascade can give chance each image patch contributing...

The CRUSADE, ACTION and ACUITY-HORIZONS scores are commonly used for predicting in-hospital major bleeding events in patients with acute coronary syndrome (ACS), but the homogeneous nature of these models' population limits simple extrapolation to other local population. We aimed compare performance three risk models Chinese patients.We evaluated defined by thrombolysis myocardial infarction (TIMI) serious (major minor) episodes, a cohort ACS either non-ST-elevation (NSTE-ACS) or...