A5004547251- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Cancer therapeutics and mechanisms
- Synthesis and Reactions of Organic Compounds
- Medicinal Plants and Bioactive Compounds
- Bioactive natural compounds
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Biological Activities
- Garlic and Onion Studies
- Signaling Pathways in Disease
- Natural product bioactivities and synthesis
- Folate and B Vitamins Research
- Lipid metabolism and disorders
- Traditional Chinese Medicine Analysis
- Cancer, Lipids, and Metabolism
- Synthesis and biological activity
- Estrogen and related hormone effects
- Neuropeptides and Animal Physiology
- Synthesis and Biological Evaluation
- Extracellular vesicles in disease
Luohe Medical College
2015-2024
Innovation Team (China)
2019-2023
Henan University of Technology
2019
Ningxia Medical University
2007-2018
Sichuan University of Arts and Science
2018
Sichuan University
2012-2016
West China Hospital of Sichuan University
2016
Peking University First Hospital
2009
Peking University
2009
Aims of the Study To investigate neuroprotective effect Lycium barbarum polysaccharide (LBP) on focal cerebral ischemic injury in mice and to explore its possible mechanism. Materials Methods Male ICR were used make model middle artery occlusion (MCAO) after intragastric administration with LBP (10, 20 40 mg/kg) Nimodipine (0.4 for seven successive days. After 24 h reperfusion, neurological scores estimated infarct volumes measured by 2, 3, 5-triphenyltetrazolium chloride (TTC) staining....
Abstract Elevated homocysteine (Hcy) levels have been reported to be involved in liver injury, and autophagy plays an important role normal hepatic physiology pathophysiology, but the mechanism underlying Hcy regulated is currently unknown. In this study, CBS +/- mice were fed with regular diet for 12 weeks establish a hyperhomocysteinemia (HHcy) model HL-7702 cells treated Hcy, we found that increases aggravates injury by downregulation of cystic fibrosis transmembrane conductance regulator...
Nobiletin (5, 6, 7, 8, 3' 4'-hexamethoxyflavone) is a major anticancer component in juice from zhishi (Rutaceae). This study aimed to investigate the inhibitory effect of on hepatic cancer cells both vitro and vivo. The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), growth curve, clonogenic assay showed that nobiletin inhibited proliferation SMMC-7721 vitro. Hoechst staining observed characteristics cell apoptosis nobiletin-treated cells, apoptotic rates treated groups...
Abstract Radioresistance is an important factor affecting the radiotherapy effect of colorectal cancer (CRC). Allicin a versatile sulfur‐containing organic compound extracted from garlic ( Allium sativum L.), which has many pharmacological effects. However, allicin on sensitivity CRC not been confirmed. The present study to observe radiosensitivity effects and explore its mechanism in radiotherapy. proliferation inhibition combined with X‐ray HCT116 cells were measured by growth curve cell...
Atherosclerosis (AS) is a progressive disease of multifactorial origin, which occurs in response to endothelial injury. Increased homocysteine (Hcy) considered major cause dysfunction, oxidative stress and DNA methylation; however, the mechanisms remain be fully elucidated. The aim present study was investigate whether Hcy causes injury cells (ECs) by effect lectin‑like oxidized‑low density lipoprotein receptor‑1 (LOX‑1) methylation through toll‑like receptor 4(TLR4)/nuclear factor...
Gentiopicroside (Gent) is promising as an important protective secoiridoid compound against pain. The present study was designed to investigate whether administration of Gent would alleviate the expression nociceptive behaviors and it cause relevant electrophysiological changes in a chronic constriction injury (CCI) model neuropathic pain mice. administered from seventh day after surgery for 8 consecutive days. Behavioral parameters sciatic functional index were assessed immediately before...
Oxysophoridine (OSR) is a major active alkaloid extracted from Sophoraalopecuroides L. The aim of the present study was to investigate induction apoptotic effects OSR on colorectal cancer cells in vivo and vitro. results MTT colony formation assays demonstrated that proliferation HCT116 inhibited by characteristics cellular apoptosis OSR‑treated were analyzed Hoechst 33258 staining. It also observed expression caspase‑3, B‑cell lymphoma‑2 (Bcl‑2) associated X protein (Bax) cytochrome c...
Oxysophocarpine is an alkaloid extracted from <i>Sophora alopecuroides</i>. We investigated the analgesic effect of oxysophocarpine on carrageenan-induced inflammatory pain in mice, order to explore its possible mechanisms. Mouse ear swelling tests and paw edema were used investigate effects mice. Morphological changes inflamed sections measured by hematoxylin-eosin staining. The mRNA protein expression extracellular signal-regulated kinase, phosphorylation kinase 1/2, cyclooxygenase-2,...
Folate deficiency is a known risk factor for liver injury; however, the underlying mechanism remains unclear. In this study, we employed high homocysteine-induced injury model of Apolipoprotein E-deficient (ApoE−/−) mice fed high-methionine diet and found that homocysteine induced endoplasmic reticulum (ER) stress cell apoptosis by downregulation cystic fibrosis transmembrane conductance regulator (CFTR) expression; observations were attenuated with supplementation dietary folate. The...
Lanthanum, a rare earth element, has been used to decrease serum phosphorus level in patients with chronic renal disease and hyperphosphatemia. We aimed observe the effect mechanism of two doses lanthanum acetate (375 750 mg/kg/day) on vascular calcification induced by vitamin D3 plus nicotine treatment rats for 4 weeks. As compared control rats, showed widespread calcified nodules irregular elastic fibers aorta von Kossa calcium staining increased aortic contents, alkaline phosphatase (ALP)...
In traditional Chinese medicine, shikonin and its derivatives, has been used in East Asia for several years the prevention treatment of diseases, including cancer. We previously identified that β,β-dimethylacrylshikonin (DA) could inhibit hepatocellular carcinoma growth. present study, we investigated inhibitory effects DA on human colorectal cancer (CRC) cell line HCT-116 vitro vivo. A viability assay showed tumor growth a time- dose-dependent manner. Flow cytometry blocks cycle at G0/G1...
Context: Oxysophocarpine (OSC), a quinolizidine alkaloid extracted from leguminous plants of the genus Robinia, is traditionally used for various diseases including neuronal disorders.Objective: This study investigated protective effects OSC on neonatal rat primary-cultured hippocampal neurons were injured by oxygen–glucose deprivation and reperfusion (OGD/RP).Materials methods: Cultured exposed to OGD 2 h followed 24 RP. (1, 2, 5 μmol/L) nimodipine (Nim) (12 added culture after but before...
Both tyrosine kinase and topoisomerase II (TopII) are important anticancer targets, their respective inhibitors widely used in cancer therapy. However, some combinations of drugs could exhibit mutually antagonistic actions drug resistance, which further limit therapeutic efficacy. Here, we report that HMNE3, a novel bis-fluoroquinolone chalcone-like derivative targets both TopII, induces tumor cell proliferation growth inhibition. The viabilities 6 different lines treated with range HMNE3...
Hyperhomocysteinemia (HHcy) is an independent risk factor for the development of atherosclerosis (AS), according to overwhelming number clinical and epidemiological studies. However, underlying pathogenic molecular mechanisms by which HHcy promotes AS remain be fully elucidated. Fatty acid binding protein 4 (FABP4) has been shown important in macrophage cholesterol trafficking. The objective present study was determine whether homocysteine (Hcy) accelerates through regulating FABP4, then...
Vascular smooth muscle cell (VSMC) proliferation is a primary pathological event in atherosclerosis (AS), and homocysteine (Hcy) an independent risk factor for AS. However, the underlying mechanisms are still lagging. Studies have used combination of methylation promoters multiple genes to diagnose tumors, thus aim current study was investigate role status several VSMCs treated with Hcy. CpG islands were identified platelet‑derived growth (PDGF), p53, phosphatase tensin homologue on...
Regulatory T cells (Tregs) are found to participate in the pathogenesis of cerebral ischemic stroke. Exosomes derived from Tregs (Treg-Exos) were mediate mechanism Tregs' roles under various physiological and pathological conditions. But Treg-Exos stroke still unclear. Here, we explored protective effects against microglial injury response oxygen-glucose deprivation/reperfusion (OGD/R) exposure. The results showed that Tregs-Exos relieved OGD/R-caused increases LDH release caspase-3 activity...