A5100685758- Epigenetics and DNA Methylation
- Catalytic Processes in Materials Science
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Catalysis and Oxidation Reactions
- Crystallization and Solubility Studies
- Folate and B Vitamins Research
- Toxin Mechanisms and Immunotoxins
- Microbial Natural Products and Biosynthesis
- Monoclonal and Polyclonal Antibodies Research
- Metal-Organic Frameworks: Synthesis and Applications
- Birth, Development, and Health
- Stress Responses and Cortisol
- RNA modifications and cancer
- Prenatal Substance Exposure Effects
- Genetic Associations and Epidemiology
- Substance Abuse Treatment and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Advanced machining processes and optimization
- Alcohol Consumption and Health Effects
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
Ningxia Medical University General Hospital
2016-2025
Hunan Provincial Maternal and Child Health Hospital
2022-2025
Ningxia Medical University
2016-2025
Boston University
2017-2025
Huazhong University of Science and Technology
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Jiangyin People's Hospital
2016-2024
Jining University
2013-2024
Changzhi Medical College
2024
Renmin University of China
2012-2024
Estrogen sulfotransferase (EST) catalyzes the transfer of sulfuryl group from 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to 17β-estradiol (E<sub>2</sub>). The sulfation E<sub>2</sub> prevents it binding to, and thereby activating, estrogen receptor. regulation EST appears be causally linked tumorigenesis in breast endometrium. In this study, recombinant human is characterized, catalytic mechanism reaction investigated ligand initial rate experiments. native enzyme a dimer 35-kDa subunits....
Background: Pharmacotherapy of alcohol dependence (AD) is at an early stage development; currently available medications have limited efficacy. It would be clinically valuable to identify, before initiation a course treatment, those patients who, based on genetic markers, are most likely respond specific pharmacotherapy. A previous report suggested that functional variant the locus encoding μ opioid receptor (Asn40Asp) such marker, in short‐term (3‐month) treatment with opioid‐blocking drug...
Abstract Genetic variation at the locus encoding brain derived neurotrophic factor (BDNF) has been implicated in some neuropsychiatric disorders such as Alzheimer's disease (AD), affective (AFDs), schizophrenia, and substance dependence. We therefore performed a mutation scan of BDNF gene to identify novel variants examined association between several phenotypes European American (EA) subjects controls. Using denaturing high performance liquid chromatography (dHPLC), we identified variant...
Abstract Genome mining of a terpene synthase gene from Emericella variecolor NBRC 32302 and its functional expression in Aspergillus oryzae led to the production new sesterterpene hydrocarbon, astellifadiene ( 1 ), having 6‐8‐6‐5‐fused ring system. The structure was initially investigated by extensive NMR analyses, further confirmed crystalline sponge method, which established absolute demonstrated usefulness method determination complex hydrocarbon natural products. Furthermore,...
Brain function and cognitive performance differ between men women in some measures. The phenotypic variation may be partially due to sex differences epigenomes transcriptomes specific brain regions [e.g. the prefrontal cortex (PFC)]. Genome-wide DNA methylation gene expression were examined postmortem PFC of 32 males 14 females (all Caucasians) using Illumina's 450K Methylation HT-12 v4 Gene Expression BeadChips, respectively. Multiple linear regression, Pearson correlation DAVID functional...
OBJECTIVE Acylcarnitines were suggested as early biomarkers even prior to insulin resistance in animal studies, but their roles predicting type 2 diabetes unknown. Therefore, we aimed determine whether acylcarnitines could independently predict by using a targeted metabolic profiling approach. RESEARCH DESIGN AND METHODS A population-based prospective study was conducted among 2,103 community-living Chinese individuals aged 50–70 years from Beijing and Shanghai with mean follow-up duration...
Sesterterpenoids are a group of terpenoid natural products that primarily biosynthesized via cyclization the C25 linear substrate geranylfarnesyl pyrophosphate (GFPP). Although long carbon chain GFPP in theory allows for many different patterns, sesterterpenoids relatively rare species among terpenoids, suggesting intriguing sesterterpenoid scaffolds have been overlooked. Meanwhile, recent identification first sesterterpene synthase has allowed discovery new by genome mining approach. In...
Paraherquonin (1), a fungal meroterpenoid produced by Penicillium brasilianum NBRC 6234, possesses unique, highly congested hexacyclic molecular architecture. Here we identified the biosynthetic gene cluster of 1 (the prh cluster) and elucidated pathway up to berkeleydione (2), which serves as key intermediate for biosynthesis well many other meroterpenoids. Interestingly, nonheme iron α-ketoglutarate-dependent dioxygenase PrhA constructs cycloheptadiene moiety afford 2 from preaustinoid A1...
The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network US (DCNN-US) aiding radiologists in classification malignant from benign FLLs.This study was conducted 13 hospitals and finally 2143 patients with 24,343 images were enrolled. Patients who had non-cystic FLLs pathological results 11 randomly divided into training internal validations (IV) cohorts 4:1 ratio developing evaluating...
Factor XIa (FXIa) is an enzyme in the coagulation cascade thought to amplify thrombin generation but has a limited role hemostasis. From preclinical models and human genetics, inhibitor of FXIa potential be antithrombotic agent with superior efficacy safety. Reversible irreversible inhibitors have demonstrated excellent without increased bleeding time animal (Weitz, J. I., Chan, N. C. Arterioscler. Thromb. Vasc. Biol. 2019, 39 (1), 7−12). Herein, we report discovery novel series macrocyclic...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies and rapidly progressive diseases. Exosomes long noncoding RNAs (lncRNAs) are emerging as vital mediators in tumor cells their microenvironment. However, detailed roles mechanisms exosomal lncRNAs PDAC progression remain unknown. Here, we aimed to clarify clinical significance lncRNA 01133 (LINC01133) PDAC. We analyzed expression LINC01133 found that was high positively correlated with higher TNM stage poor...
We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of µ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol (AD) and/or drug (DD)] and 338 EA healthy controls. These SNPs delineated two haplotype blocks. Genotype distributions for all were in Hardy–Weinberg equilibrium (HWE) controls, but cases, four Block I three II showed deviation from HWE. Significant differences found between cases controls allele...
In a previous study we showed that the murine homeodomain protein Msx-1 is potent transcriptional repressor and this activity independent of its DNA binding function. The implication these findings repression by mediated through association with certain factors rather than interaction recognition sites, which prompted investigation relevant factors. Here show interacts directly TATA (TBP) but not several other general transcription This homeodomain, specifically residues in N-terminal arm....
Abstract Ligation of the receptor for advanced glycation end products (RAGE) occurs during inflammation. Engagement RAGE results in enhanced expression addressins and it is therefore, not surprising that previous studies have shown a role RAGE/ligand interactions immune responses including cell/cell contact but spontaneous autoimmunity has been clearly defined. To study autoimmune diabetes, we tested ability soluble RAGE, scavenger ligands, late stages diabetes development NOD mouse-disease...