A5101509972- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Ultrasound and Hyperthermia Applications
- Growth Hormone and Insulin-like Growth Factors
- Lung Cancer Treatments and Mutations
- Diabetes and associated disorders
- Thyroid Cancer Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer, Hypoxia, and Metabolism
- Regulation of Appetite and Obesity
- Renal cell carcinoma treatment
- Sexual Differentiation and Disorders
- Immune Cell Function and Interaction
- Adrenal Hormones and Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Asthma and respiratory diseases
- Biochemical Analysis and Sensing Techniques
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Pain Mechanisms and Treatments
- Diabetes Management and Research
- Hormonal Regulation and Hypertension
- Sinusitis and nasal conditions
Guangzhou Medical University
2025
Union Hospital
2024
Huazhong University of Science and Technology
2024
Second Xiangya Hospital of Central South University
2012-2024
Central South University
2012-2024
Hunan Provincial Center for Disease Control and Prevention
2023-2024
Huazhong Agricultural University
2024
Renji Hospital
2021-2023
Children's Hospital of Fudan University
2011-2022
First Affiliated Hospital of Anhui Medical University
2022
The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network US (DCNN-US) aiding radiologists in classification malignant from benign FLLs.This study was conducted 13 hospitals and finally 2143 patients with 24,343 images were enrolled. Patients who had non-cystic FLLs pathological results 11 randomly divided into training internal validations (IV) cohorts 4:1 ratio developing evaluating...
Abstract The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene product, binds to its receptors and exerts opposing biologic functions mature BDNF. proBDNF is expressed in peripheral tissues but remain elusive. Here we showed that predominant receptor, p75 pan-neurotrophin receptor were upregulated nerve fibers inflammatory cells local tissue pain. Neutralization by polyclonal antibody attenuated pain different models Unilateral intra-plantar supplementation...
Characterization of Hepatic Tumors: Value Contrast-Enhanced Coded Phase-Inversion Harmonic AngioYan Ling Wen1 2, Masatoshi Kudo1, Rong Qin Zheng1 3, Hong Ding1 4, Pei Zhou1 5, Yasunori Minami1, Hobyung Chung1, Masayuki Kitano1, Toshihiko Kawasaki1 and Kiyoshi Maekawa6Audio Available | Share
Background and Aims: To observe safety influence on viral load peripheral T lymphocyte subsets of combination therapy with percutaneous microwave ablation (PMWA) adoptive immunotherapy in hepatocellular carcinoma (HCC) hepatitis B. Methods: Ten HCC (D≤5 cm, fewer than 3 tumors) patients were treated radical PMWA three courses immunotherapy, which started PMWA, 2 weeks post-PMWA, months after PMWA. Peripheral blood mononuclear cells differentiated into phenotypically confirmed DCs effector...
Purpose: To compare the effectiveness of ultrasound (US)-guided percutaneous 915 MHz microwave (MW) ablation with 2450 MW for large hepatocellular carcinoma (HCC) (>4 cm in diameter).
Lifestyle changes including COVID-19 lockdown cause weight gain and may change obesity trends; however, timely are largely unknown monitoring measures usually lack. This first large-scale study aimed to analyze the real-world national trends of prevalence Chinese children in past five years, impact pandemic on pediatric development through both mobile- hospital-based data. included aged 3 19 years old all over China from January 2017 April 2021. Hospital-measured parent-reported cases XIGAO...
To investigate the role of C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) as early predictors infectious complications after laparoscopic gastric cancer surgery.
Purpose: The aim of the study was to prospectively evaluate safety and effectiveness percutaneous microwave (MW) ablation for liver cancer adjacent diaphragm.
In visceral pain, anxiety and pain occur simultaneously, but the etiogenesis of this effect is not yet well-described. The anterior cingulate cortex (ACC) known to be associated with affective response noxious stimuli. aim current study define role ACC extracellular signal-regulated (ERK)-1 and-2 (ERK1/2) activity in development pain-related anxiety/depression nocifensive acetic acid (AA)-elicited pain. model was created by intraperitoneal (ip) injection AA female Kunming mice. We found that...
The efficacy of lymph node ratio (LNR) as a prognostic indicator in locally advanced gastric cancer (LAGC) patients underwent radical resection after neoadjuvant immunochemotherapy (NICT) remains to be demonstrated. objective the current retrospective study is investigate relationship between LNR and survival with LAGC who NICT. A analysis was performed on 121 cases NICT July 2020 October 2023. values were divided into two groups using X-tile software. first group, designated low comprised ≤...
Exogenous androgen supplement is an optional treatment for micropenis; however, its use in childhood controversial due to potential side effects.Twenty-three children (mean age: 4.07±3.4 years) with micropenis of unknown causes harboring the 46,XY karyotype were recruited open prospective study. Androgen receptor (AR), steroid 5α-reductase-2 (SRD5A2), and SRY genes sequenced; 2.5% dihydrotestosterone (DHT) transdermal gel (0.1-0.3 mg/kg/day) was applied titrated within normal DHT serum...
We investigated the correlation between growth hormone receptor (GHR) exon 3 polymorphism and metabolic profiles of Chinese children with obesity.A total 409 obese/overweight 206 normal weight were recruited. Anthropological biochemical indexes including insulin lipid measured. Genomic DNA was extracted from peripheral blood leukocytes, GHR genotyped by polymerase chain reaction. Homeostasis model assessment for resistance index (HOMA-IR) sensitivity (ISI) calculated using homeostasis...
Type 1 diabetes (T1D) is an autoimmune disease that has strong contribution of genetic factors to its etiology. We aimed assess the association between non-HLA genes and T1D in a Chinese case-control cohort recruited from multiple centers consisting 364 patients with 719 unrelated healthy children. genotyped 55 single nucleotide polymorphisms (SNP) markers located 16 (VTCN1, PTPN22, CTLA4, SUMO4, CD274, IL2RA, INS, DHCR7, ERBB3, VDR, CYP27B1, CD69, CD276, PTPN2, UBASH3A, IL2RB) using...
This cohort study aimed to identify the characteristics and risk factors of adult idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) further explore prognostic IIM-ILD. We extracted data regarding 539 patients with laboratory-confirmed myopathy (IIM) or without (ILD) from Second Xiangya Hospital Central South University between January 2016 December 2021. The regression analysis was conducted possible for ILD as well mortality. Of IIM patients, 343 (64.6%) were...
<i>Purpose:</i> To observe the visibility and changes in echogenicity of ablated tumor nontumor areas after radiofrequency ablation (RFA) over time using gray-scale sonography, and, consequently, to decide on best timing for contrast-enhanced sonography evaluate response hepatocellular carcinoma RFA. <i>Materials Methods:</i> Thirty-eight patients with 48 nodules underwent Consecutive sonographic observations were made 10 min before RFA at five points within 4 days...
Growth differentiation factor 5 (GDF5) was reported to regulate brown adipogenesis; however, its effects on insulin sensitivity, full metabolic syndrome spectrum, and the thermogenesis in subcutaneous white adipose tissue (sWAT) have not been elucidated yet. We thus generated fatty acid-binding protein 4 (Fabp4)-GDF5 transgenic (TG) mice showed that GDF5 TG developed a relative lean phenotype high-fat diet (HFD) increased sensitivity. Over expression of tissues greatly promoted thermogenic...
The neuroendocrine system coordinates metabolic and behavioral adaptations to fasting, including reducing energy expenditure, promoting counterregulation, suppressing satiation anxiety engage refeeding. Here, we show that steroid receptor coactivator-2 (SRC-2) in pro-opiomelanocortin (POMC) neurons is a key regulator of all these responses fasting. POMC-specific deletion SRC-2 enhances the basal excitability POMC neurons; mutant mice fail efficiently suppress expenditure during food...