A5100450487- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Sinusitis and nasal conditions
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Long-Term Effects of COVID-19
- Respiratory and Cough-Related Research
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Esophagitis
- Antimicrobial Peptides and Activities
- Nasal Surgery and Airway Studies
- Metabolism and Genetic Disorders
- Graphene and Nanomaterials Applications
- Cardiac Imaging and Diagnostics
- Traditional Chinese Medicine Analysis
- Hearing Loss and Rehabilitation
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Nanoplatforms for cancer theranostics
- Head and Neck Surgical Oncology
- Respiratory viral infections research
- Hearing, Cochlea, Tinnitus, Genetics
Guangzhou Medical University
2016-2025
Guangzhou Women and Children Medical Center
2014-2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
Linyi People's Hospital
2012-2024
Qinghai No.3 People's Hospital
2023
Anshun University
2023
State Key Laboratory of Plant Genomics
2022
Nanjing Agricultural University
2022
National Cancer Institute
2022
Objective To understand the clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection (CDBC), and therefore contributing to their early identification prognosis estimation. Method 905 from 7 different centers were enrolled. The demography data, manifestations, laboratory results, treatments collected accordingly for further analyses. Results Around 9.5% enrolled CDBC. Older or cardiovascular comorbidities have increased CDBC probability. Increased body...
Abstract Background Although previous studies had confirmed the effectiveness and safety of subcutaneous immunotherapy (SCIT) sublingual (SLIT), respectively, direct head‐to‐head comparison SCIT vs SLIT is sparse. We aimed to compare efficacy, safety, compliance in allergic rhinitis (AR) children. Methods This study a prospective, open‐label, single‐center performed between June 2017 2018. A total 325 children were grouped into SLIT, Alutard (SCIT1), NovoHelisen Depot (NHD) (SCIT2) according...
Abstract Background Regulatory T cells (Tregs) play central roles in limiting airway allergic inflammation and preventing inappropriate Th2 responses to environmental allergens. This study aims evaluate the role of miR‐181a miR‐155 regulation differentiation function Tregs through both vivo vitro studies. Methods The CD4 + were purified from peripheral blood mononuclear (PBMCs) rhinitis (AR) children, respectively. miR‐155/181a mimics inhibitors transfected into Tregs. evaluated by flow...
Hedysarum multijugum Maxim.-Chuanxiong rhizoma compound (HCC) is a common herbal formula modified from Buyang Huanwu decoction. Clinical trials have demonstrated its therapeutic potential for ischemic stroke (IS). However, the mechanism of HCC remains unclear. The HCC's components were collected TCMSP database and TCM@Taiwan database. After that, targets predicted by PharmMapper. IS-related genes obtained GeneCards, OMIM protein-protein interaction (PPI) data IS String DAVID platform was...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Based on symptoms, COVID-19 cases can be classified as symptomatic or asymptomatic. However, there is limited information about the differences between patients with and without pneumonia. Our study aimed to further discuss spectrum clinical characteristics of asymptomatic
This retrospective, multicenter study investigated the risk factors associated with intensive care unit (ICU) admission and transfer in 461 adult patients confirmed coronavirus disease 2019 (COVID-19) hospitalized from 22 January to 14 March 2020 Hunan, China. Outcomes of ICU non-ICU were compared, a simple nomogram for predicting probability after hospital was developed based on initial laboratory data using Cox proportional hazards regression model. Differences indices observed between...
LMB-100 is a recombinant immunotoxin composed of Fab linked to toxin. It kills cells expressing human mesothelin (hMSLN), which highly expressed on the surface mesothelioma and many other cancer cells. Clinically, we observed some patients had delayed responses an anti-hMSLN treatment, suggesting induction anti-tumor immunity. We aimed develop mouse model investigate whether alone can induce immunity study mechanism this An immunocompetent transgenic was used grow AB1 hMSLN in peritoneal...
Background: Although numerous studies have focused on diagnostic biomarkers to help identify allergic rhinitis (AR), data the characteristics of pediatric AR with different severity is limited. We aimed compare severity. Methods: A total 1054 children were enrolled and classified into mild intermittent AR, persistent moderate‐to‐severe AR. All surveyed using a questionnaire that included detailed demographic information. Blood cell analysis was performed an automatic hematology analyzer....
Background: Certain patterns of children's serum immunoglobulin E (IgE) sensitivity to aeroallergens may offer useful clinical insight into forecasting the course and prognosis allergic rhinitis (AR). The study aimed investigate changes in aeroallergen sensitization children with AR during last decade compare pre- post-coronavirus disease 2019 (COVID-19) pandemic Children who visited our center. Methods: This is a retrospective study, examining IgE nine from 21,362 (1-12 years old) Guangzhou...
Abstract The study of parameter inversion and its application is critical in the dynamic model marine ecosystems, but research has a problem with incorrect performance locating. issue inverse problem-solving methods unable to deal inaccurate positioning results are not enough. Therefore, Sensitivity Analysis Methods-based on ecosystem dynamics provided, Marine evaluated. Firstly, influence factors were found by partial sensitivity analysis theory, basis researching inversion, index divided....
Background: Allergic rhinitis (AR) is triggered by immunoglobulin E (IgE)-mediated immune responses to airborne allergens. Recent studies highlight the pivotal role of T follicular helper 2 (Tfh2) cells in IgE production. Interleukin-37 (IL-37) has emerged as an intrinsic modulator innate immunity and inflammatory processes. We aimed investigate regulatory effect IL-37 on Tfh2 pathogenesis AR. Methods: Blood samples were collected from AR patients controls. The levels frequency detected...
Background . Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as fundamental inhibitor innate inflammatory and immune responses, especially its isoform IL-37b. Objective This study was undertaken to evaluate the expression regulation IL-37b in children with allergic rhinitis (AR). Methods Forty AR twenty-five normal controls were included. The relationship between Th1/2 cytokines production serum nasal lavage examined by enzyme-linked immunosorbent assay (ELISA)....
<i>Objective:</i> To evaluate the efficacy of long-term clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis without nasal polyps (CRSnNP). <i>Methods:</i> Thirty-three CRSnNP were enrolled and subjected to CAM for 12 weeks (250 mg daily). The total symptom scores (TNSS), resistance inflammatory mediators including interleukin (IL)-8 myeloperoxidase (MPO) evaluated at 0 12. Quality life (QoL) was assessed all by using...