A5054907579- Inflammasome and immune disorders
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- RNA modifications and cancer
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Channels and Receptors
- Cancer-related molecular mechanisms research
- Enzyme Catalysis and Immobilization
- Adenosine and Purinergic Signaling
- Nerve injury and regeneration
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Diet, Metabolism, and Disease
- Digestive system and related health
- Immune Cell Function and Interaction
- Olfactory and Sensory Function Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Sulfur Compounds in Biology
- Obstructive Sleep Apnea Research
- Sulfur-Based Synthesis Techniques
- Biofuel production and bioconversion
- Fibroblast Growth Factor Research
University of South China
2019-2025
Affiliated Hospital of Southwest Medical University
2019-2024
First Affiliated Hospital of University of South China
2019-2024
Zhongshan Hospital of Xiamen University
2020-2022
Fudan University
2020-2022
Sun Yat-sen University
2017-2020
Indiana University – Purdue University Indianapolis
2019
Indiana University School of Medicine
2019
Guangzhou University of Chinese Medicine
2018
Central South University
2012-2017
Abstract The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene product, binds to its receptors and exerts opposing biologic functions mature BDNF. proBDNF is expressed in peripheral tissues but remain elusive. Here we showed that predominant receptor, p75 pan-neurotrophin receptor were upregulated nerve fibers inflammatory cells local tissue pain. Neutralization by polyclonal antibody attenuated pain different models Unilateral intra-plantar supplementation...
Sestrin 3 (Sesn3) belongs to the three‐member sestrin protein family. Sestrins have been implicated in antioxidative stress, adenosine monophosphate–activated kinase and mammalian target of rapamycin signal transduction, metabolic homeostasis. However, role Sesn3 development nonalcoholic steatohepatitis (NASH) has not previously studied. In this work, we generated whole‐body knockout liver‐specific transgenic mice investigate hepatic function diet‐induced NASH. With only 4 weeks dietary...
Endotoxemia is a severe inflammation response induced by infection especially bacterial endotoxin translocation, which severely increases mortality in combination with acute colon injury. Bromodomain-containing protein 4 (BRD4) an important Bromo and Extra-Terminal (BET) to participate inflammatory responses. However, it still unknown about the specific connection between BRD4 inflammation-related pyroptosis endotoxemia colon. Here, through evaluating mucous morphology expression of tight...
Betaine rich in beet is used as an important source of human nutrition. Here this study aims to explore whether betaine supplementation can protect against acute sever ulcerative colitis (ASUC) and the underlying mechanism METHODS AND RESULTS: ASUC model induced by dextran sulfate sodium (DSS), effects a methyl donor on are evaluated. mitigates changes, for example, elevated DAI, weight loss, spleen enlargement, colon shortening, disordered colonic mucosa. The protective barrier integrity...
Ulcerative colitis (UC) is a typical type of inflammatory bowl disease, which accompanied by an increased risk depression and anxiety-related psychological symptoms. Betaine naturally derived compound that can function as anti-inflammatory drug neuromodulator. In-depth exploration the potential role betaine in treating UC-related anxiety crucial. This study aimed to elucidate effects on clarify underlying mechanisms. A dextran sulfate sodium (DSS)-induced mice model was established 4% DSS...
Abstract The assembly of two functional molecules via a sulfur linking atom allows an access to diverse array thioether‐containing compounds. Herein, we disclose metal‐free thiolation imidazopyridines with variety functionalized haloalkanes using elemental sulfur. magnified image
Neuropathic pain evoked by nerve injury is frequently accompanied deterioration of emotional behaviors, but the underlying signaling mechanisms remain elusive. Glutamate (Glu) major mediator excitatory synaptic transmission throughout brain, and abnormal activity glutamatergic system has been implicated in pathophysiology associated comorbidities. In this study we used partial sciatic ligation (PSNL) model neuropathic rats to characterize development anxiety-like behavior, expression...
Introduction Cholestatic liver injury (CLI) is a dysfunction closely associated with oxidative stress and bile acid (BA) metabolic disorders, but effective therapies are lacking.The use of ursolic (UA) α -Tocopherol succinate (VES) together for treating CLI promising due to their respective effects on regulating metabolism providing antioxidant activity. Methods In this study, we synthesized drug-drug nanocrystals (UA-NSps) composed UA VES treat evaluated synergistic therapeutic by...
• miR-32-5p KO has no effect on the normal behavior and brain development of animals. LPS enhanced expression miR-32-5p, astrocytes glutamate receptor. eliminates LPS-induced depression behavior. inhibits overactivation receptor expression.
The Langlois reagent was found to be effective for the isothiocyanation of primary amines in presence copper iodide and diethyl phosphonate.
Chronic social isolation (SI) stress, which became more prevalent during the COVID-19 pandemic, contributes to abnormal behavior, including mood changes and cognitive impairment. Known as a functional nutrient, betaine has potent antioxidant anti-inflammatory properties in vivo. However, whether can alleviate behavior induced by chronic SI mice remains unknown. In this study, we investigated efficacy of treatment behavioral its underlying mechanism. Three-week-old male were randomly housed...