A5100653361- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Autism Spectrum Disorder Research
- Nicotinic Acetylcholine Receptors Study
- Epigenetics and DNA Methylation
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Child Abuse and Trauma
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health Research Topics
- Anaerobic Digestion and Biogas Production
- Intimate Partner and Family Violence
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Mapping and Diversity in Plants and Animals
Yale University
2016-2025
Tianjin Anding Hospital
2021-2025
Tianjin People's Hospital
2025
Henan University of Urban Construction
2024
Beijing HuiLongGuan Hospital
2015-2024
Peking University
2018-2024
Peking University First Hospital
2022
University of Tartu
2022
Tianjin Medical University
2021
Xinxiang Medical University
2021
Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired many neuropsychiatric disorders. Wang et al. [Wang, J.C., Hinrichs, A.L., Stock, H., Budde, J., Allen, R., Bertelsen, S., Kwon, J.M., Wu, W., Dick, D.M., Rice, J. (2004) Evidence of common specific genetic effects: association the acetylcholine M2 gene with alcohol dependence major depressive syndrome. Hum. Mol. Genet., 13, 1903–1911] reported that variation CHRM2 predisposed to (AD) We...
We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of µ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol (AD) and/or drug (DD)] and 338 EA healthy controls. These SNPs delineated two haplotype blocks. Genotype distributions for all were in Hardy–Weinberg equilibrium (HWE) controls, but cases, four Block I three II showed deviation from HWE. Significant differences found between cases controls allele...
This study examined whether a reportedly functional polymorphism in the gene encoding mu-opioid receptor protein (A118G, which causes an Asn40Asp substitution receptor's extracellular domain), modifies cortisol response to opioid antagonist naloxone. The occurs commonly European Americans and some other population groups, underscoring its potential phenotypic significance.Using balanced, within-subject design involving two test sessions over period of 3-7 days, we ACTH responses intravenous...
There have been many conflicting reports concerning the association of DRD2 locus with alcohol dependence (AD). To investigate whether these findings could be reconciled by considering genomic region in greater detail, we conducted two separate studies AD 1220 European-American subjects using family-based (488 subjects) and case–control (318 cases 414 controls) designs, 43 single nucleotide polymorphisms mapped to gene cluster NCAM1, TTC12, ANKK1 DRD2. We used a generalized linear model...
Each gene in the chromosome 11q23 cluster of NCAM1, TTC12, ANKK1, and DRD2 is functionally linked to dopamine brain. Many association studies substance dependence (SD), including alcohol (AD) drug (DD), have been reported; results inconsistent. Recent considered this more comprehensively, examining SD with several risk variants mapped other genes cluster. Because comorbid AD DD (AD+DD) common, we hypothesized that heterogeneity diagnoses studied might contributed inconsistency prior...
Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct of structures involved the presumed peripheral-central interaction still unclear. Seventy-nine previously treatment-naïve first-episode patients who were within 2-week antipsychotics initial stabilization, and 41 age- sex-matched healthy controls enrolled study. Group differences subcortical regional measured by MRI subclinical cardiovascular,...
Abstract Our objective was to investigate the relationship between gene encoding μ‐opioid receptor (OPRM1) and susceptibility substance dependence in European‐American (EA) African‐American (AA) subjects. Eight single nucleotide polymorphisms (SNPs) at OPRM1 locus, i.e., −2044C/A, −1793T/A, −1699insT, −1469T/C, −1320A/G, −111C/T, +17C/T (Ala6Val), +118A/G (Asn40Asp) were genotyped 676 subjects: 318 EA subjects 124 AA with dependence, 179 normal controls, 55 controls. Affection status defined...
We found strong associations between ADH4 gene variation and alcohol drug dependence by the Hardy-Weinberg Disequilibrium (HWD) test case-control association analysis in an initial study. The present study aimed to confirm these findings controlling for population stratification admixture effects which HWD methods may be vulnerable. In addition 365 unrelated healthy controls 560 cases study, we evaluated 104 small nuclear families with affected offspring who had diagnoses of and/or...
Piwi-interacting RNAs (piRNAs) are the non-coding with 24-32 nucleotides (nt). They exhibit stark differences in length, expression pattern, abundance, and genomic organization when compared to micro-RNAs (miRNAs). There hundreds of thousands unique piRNA sequences each species. Numerous piRNAs have been identified deposited public databases. Since were originally discovered well-studied germline, a few other studies reported presence somatic cells including neurons. This paper reviewed...
The Epstein-Barr virus (EBV) is associated with a variety of cancers, including gastric cancer, which has one the highest mortality rates all human cancers. Long non-coding RNAs (lncRNAs) have been suggested to important causal roles in cancer. However, interaction between lncRNAs and EBV not yet studied. To this end, we sequenced 11,311 144,826 protein-coding transcripts from four types tissue: non-EBV-infected carcinoma (EBVnGC) its adjacent normal tissue, EBV-associated (EBVaGC) tissue....
Several genome-wide association studies (GWASs) reported tens of risk genes for alcohol dependence, but most them have not been replicated or confirmed by functional studies. The present study used a GWAS to search novel, and replicable gene regions dependence. Associations all top-ranked SNPs identified in discovery sample 681 African-American (AA) cases with dependence 508 AA controls were retested primary replication 1,409 European-American (EA) 1,518 EA controls. associations then...
Abstract Glutamate carboxypeptidase II ( GCPII ) is a transmembrane zinc metallopeptidase found mainly in the nervous system, prostate and small intestine. In glia‐bound mediates hydrolysis of neurotransmitter N‐acetylaspartylglutamate NAAG into glutamate N‐acetylaspartate. Inhibition has been shown to attenuate excitotoxicity associated with enhanced transmission under pathological conditions. However, different strains mice lacking gene are reported exhibit striking phenotypic differences....