A5028026003- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Gene expression and cancer classification
- Atmospheric Ozone and Climate
- Atmospheric aerosols and clouds
- Bioinformatics and Genomic Networks
- Air Quality Monitoring and Forecasting
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Research and Splicing
- Advanced Chemical Physics Studies
- Atmospheric and Environmental Gas Dynamics
- Photochemistry and Electron Transfer Studies
- Pluripotent Stem Cells Research
- Vehicle emissions and performance
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Spectroscopy and Quantum Chemical Studies
- Gene Regulatory Network Analysis
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- CRISPR and Genetic Engineering
ShanghaiTech University
2015-2025
Shanghai Advanced Research Institute
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Chinese Academy of Sciences
2015-2024
Institute of Earth Environment
2016-2024
Center for Excellence in Molecular Cell Science
2012-2024
University of Chinese Academy of Sciences
2017-2024
North China Electric Power University
2024
University of Science and Technology of China
2009-2022
Academy of Mathematics and Systems Science
2020
Abstract. Rapid industrialization and urbanization have caused frequent occurrence of haze in China during wintertime recent years. The sulfate aerosol is one the most important components fine particles (PM2. 5) atmosphere, contributing significantly to formation. However, heterogeneous formation mechanism remains poorly characterized. relationships observed with PM2. 5, iron, relative humidity Xi'an, been employed evaluate develop a parameterization involving water for incorporation into...
Abstract Context In 2020, the terminology of metabolic dysfunction–associated fatty liver disease (MAFLD) was proposed to replace nonalcoholic (NAFLD). Objectives This work aimed investigate prevalence and incidence MAFLD evaluate its effects on incident extrahepatic diseases. Methods A total 6873 individuals, with a 4.6-year follow-up, were included in this study. Associations NAFLD diabetes, chronic kidney (CKD), cardiovascular (CVD) examined using logistic regression Cox proportional...
Abstract. Rapid growth of industrialization, transportation, and urbanization has caused increasing emissions ozone (O3) precursors recently, enhancing the O3 formation in eastern China. We show here that China experienced widespread persistent pollution from April to September 2015 based on observations 223 cities. The observed maximum 1 h concentrations exceed 200 µg m−3 almost all cities, 400 more than 25 % even 800 six cities average daily are 160 45 have been exceeded over 10 days 129...
OBJECTIVE Acylcarnitines were suggested as early biomarkers even prior to insulin resistance in animal studies, but their roles predicting type 2 diabetes unknown. Therefore, we aimed determine whether acylcarnitines could independently predict by using a targeted metabolic profiling approach. RESEARCH DESIGN AND METHODS A population-based prospective study was conducted among 2,103 community-living Chinese individuals aged 50–70 years from Beijing and Shanghai with mean follow-up duration...
Signal transducer and activator of transcription 3 (STAT3) was reported to be involved in adipogenesis. However, the regulating mechanism STAT3 remains unclear. The present results showed that activated within 2-h adipogenic induction, which phosphorylated translocated from cytoplasm nucleus. In addition, we detected Janus kinase2 (JAK2) acted upstream activation at early stage Accordingly, JAK2 inhibitor AG490 siRNAs led partial inhibition activation, 3T3-L1 adipocyte differentiation....
Abstract. Organic aerosol (OA) concentrations are simulated over the Beijing–Tianjin–Hebei (BTH) region from 9 to 26 January 2014 using Weather Research and Forecasting model coupled with chemistry (WRF-CHEM), goal of examining impact heterogeneous HONO sources on SOA formation different pathways during wintertime haze days. The generally shows good performance respect simulating air pollutants organic aerosols against measurements in BTH. Model results show that substantially enhance...
Significance Aerosol–radiation interaction (ARI) not only constitutes one of the major uncertainties in climate prediction, but also significantly deteriorates particulate matter (PM) pollution during heavy haze events. However, modification photolysis caused by aerosol absorbing and/or scattering solar radiation (referred to as aerosol–photolysis or API) changes atmospheric oxidizing capability and influences secondary formation. The synergetic effect API ARI on PM is quantitatively...
Abstract. In the present study, WRF-CHEM model is used to evaluate contributions of trans-boundary transport air quality in Beijing during a persistent pollution episode from 5 14 July 2015 Beijing–Tianjin–Hebei (BTH), China. Generally, predicted temporal variations and spatial distributions PM2.5 (fine particulate matter), O3 (ozone), NO2 are good agreement with observations BTH. The also reproduces reasonably well aerosol species compared measurements Beijing. factor separation approach...
Abstract. In the present study, a persistent heavy haze episode from 13 to 20 January 2014 in Beijing–Tianjin–Hebei (BTH) is simulated using WRF-CHEM model through ensemble simulations investigate impacts of meteorological uncertainties on formation. Model results show that conditions substantially influence aerosol constituent at an observation site Beijing, and ratio spread mean (RESM) exceeds 50 %. The generally preforms well reproducing fine particles' (PM2.5) temporal variations spatial...
Abstract. Black carbon (BC) aerosol has important effects on the climate and hydrology of Tibetan Plateau (TP). An intensive measurement campaign was conducted at Lulang (∼ 3300 m a.s.l. – above sea level), southeastern TP, from September to October 2015, investigate sources physicochemical characteristics refractory BC (rBC) aerosol. The average rBC mass concentration 0.31 ± 0.55 µg m−3, which is higher than most prior results for TP. A clear diurnal cycle in showed high values morning low...
Abstract. The implementation of the Air Pollution Prevention and Control Action Plan in China since 2013 has profoundly altered ambient pollutants Beijing–Tianjin–Hebei (BTH) region. Here we show observations substantially increased O3 concentrations (about 30 %) a remarkable increase ratio organic carbon (OC) to elemental (EC) BTH during autumn from 2015, revealing an enhancement atmospheric oxidizing capacity (AOC) secondary aerosol (SOA) formation. To explore impacts increasing AOC on SOA...
Abstract. In the present study, WRF-Chem model is used to assess contributions of residential coal combustion (RCC) emissions air quality in Beijing–Tianjin–Hebei (BTH) during a persistent pollution episode from 9 25 January 2014. general, predicted temporal variations and spatial distributions mass concentrations pollutants are good agreement with observations at monitoring sites BTH. The also reasonably reproduces aerosol species when compared spectrometer measurements Beijing. RCC play an...
Abstract. Atmospheric aerosols scatter or absorb a fraction of the incoming solar radiation to cool warm atmosphere, decreasing surface temperature and altering atmospheric stability further affect dispersion air pollutants in planetary boundary layer (PBL). In present study, simulations during persistent heavy haze pollution episode from 5 December 2015 4 January 2016 North China Plain (NCP) were performed using Weather Research Forecasting model with Chemistry (WRF-Chem) comprehensively...
Abstract. Water vapor has been proposed to amplify the severe haze pollution in China by enhancing aerosol–radiation feedback (ARF). Observations have revealed that near-surface PM2.5 concentrations ([PM2.5]) generally exhibit an increasing trend with relative humidity (RH) North Plain (NCP) during 2015 wintertime, indicating aerosol liquid water (ALW) caused hygroscopic growth could play important role formation and accumulation. Simulations a persistent heavy episode from 5 December 4...
Gold nanoparticles (AuNPs) are often used as vehicles to deliver drugs or biomolecules, due their mild effect on cell survival and proliferation. However, little is known about cellular metabolism. Here we examine the in vivo of AuNPs metabolism using Drosophila a model. vertebrates possess similar basic metabolic functions highly conserved PI3K/Akt/mTOR signaling pathway plays central role regulation energy both organisms. We show that dietary enter fat body, key tissue larvae....
In mammals, leptin regulates food intake and energy balance mainly through the activation of LepRb in hypothalamus, estrogen has a leptin-like effect hypothalamic control metabolism. However, it remains to be elucidated how signaling is intertwined with pathway. We show here that Shp2, nonreceptor tyrosine phosphatase, acts integrate signals. The expression dominant-active mutant (Shp2(D61A)) forebrain neurons conferred female, but not male, transgenic mice resistance high-fat diet...
Little is known about how chronic inflammation contributes to the progression of hepatocellular carcinoma (HCC), especially initiation cancer. To uncover critical transition from HCC and molecular mechanisms at a network level, we analyzed time-series proteomic data woodchuck hepatitis virus/c-myc mice age-matched wt-C57BL/6 using our dynamical biomarker (DNB) model. DNB analysis indicated that 5th month after birth transgenic was period cancer initiation, just before transition, which...