A5012709162- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Diet and metabolism studies
- Diabetes and associated disorders
- Bariatric Surgery and Outcomes
- Cardiovascular Health and Disease Prevention
- Fibroblast Growth Factor Research
- Adipokines, Inflammation, and Metabolic Diseases
- Retinal Diseases and Treatments
- Lipid metabolism and disorders
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Peroxisome Proliferator-Activated Receptors
- Genetic Associations and Epidemiology
- Bone health and osteoporosis research
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Diabetes Management and Education
Shanghai Sixth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Shanghai Clinical Research Center
2014-2023
Diabetes Foundation
2014-2023
Nanjing Agricultural University
2023
Peking University
2023
XinHua Hospital
2018
Jiangsu Province Hospital
2017
Continuous glucose monitoring (CGM) has provided new measures of glycemic control that link to diabetes complications. This study investigated the association between time in range (TIR) assessed by CGM and diabetic retinopathy (DR).A total 3,262 patients with type 2 were recruited. TIR was defined as percentage spent within 3.9-10.0 mmol/L during a 24-h period. Measures variability (GV) well. DR determined using fundus photography graded 1) non-DR; 2) mild nonproliferative (NPDR); 3)...
Abstract Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1–4 . For clinical doses of metformin, AMP-activated protein kinase (AMPK) a major role in its mechanism action 4,5 ; however, direct molecular target metformin remains unknown. Here we show that clinically relevant concentrations inhibit lysosomal proton pump v-ATPase, which is central node for AMPK activation following glucose starvation 6 We synthesize...
Gut microbiota are associated with essential various biological functions in humans through a "network" of microbial–host co-metabolism to process nutrients and drugs modulate the activities multiple pathways organ systems that linked different diseases. The microbiome impacts strongly on metabolic phenotypes host, hence, readouts can give insights into functional metagenomic activity. We applied an untargeted mass spectrometry (MS) based metabonomics approach profile normal Wistar rats...
Background: Time in range (TIR) is an emerging metric of glycemic control and reported to be associated with microvascular complications diabetes. We sought investigate the association TIR obtained from continuous glucose monitoring (CGM) carotid intima-media thickness (CIMT) as a surrogate marker cardiovascular disease (CVD). Methods: Data 2215 patients type 2 diabetes were cross-sectionally analyzed. 3.9-10.0 mmol/L was evaluated CGM. CIMT measured using high-resolution B-mode...
Abstract Recent studies revealed strong evidence that branched-chain and aromatic amino acids (BCAAs AAAs) are closely associated with the risk of developing type 2 diabetes in several Western countries. The aim this study was to evaluate potential role BCAAs AAAs predicting development Chinese populations. serum levels valine, leucine, isoleucine, tyrosine, phenylalanine were measured a longitudinal cross sectional total 429 participants at different stages development, using an...
Abstract Context In 2020, the terminology of metabolic dysfunction–associated fatty liver disease (MAFLD) was proposed to replace nonalcoholic (NAFLD). Objectives This work aimed investigate prevalence and incidence MAFLD evaluate its effects on incident extrahepatic diseases. Methods A total 6873 individuals, with a 4.6-year follow-up, were included in this study. Associations NAFLD diabetes, chronic kidney (CKD), cardiovascular (CVD) examined using logistic regression Cox proportional...
Abstract Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction T2D are underweight or have normal weight. Several studies linked gut microbiome to and T2D, but role microbiota lean individuals having unique clinical characteristics remains unclear. A metagenomic targeted metabolomic analysis is conducted 182 abdominally obese without newly diagnosed T2D. The abundance Akkermansia muciniphila ( A. ) significantly decreases than not comparison Its correlates...
Hyocholic acid (HCA) is a major bile (BA) species in the BA pool of pigs, known for its exceptional resistance to spontaneous development diabetic phenotypes. HCA and derivatives are also present human blood urine. We investigate whether profiles can predict metabolic disorders. find first cohort (n = 1107) that both obesity diabetes associated with lower serum concentrations species. A separate study 91) validates this finding further reveals individuals pre-diabetes levels feces. Serum...
Abstract Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as supplement influences obesity-related outcomes. Here, show RS supplementation 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance individuals excess body...
Abstract Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary physicians (PCPs), particularly in low-resource settings. Here, bridge the gaps, we developed an integrated image–language system (DeepDR-LLM), combining large language model (LLM module) image-based deep learning (DeepDR-Transformer), provide individualized management recommendations PCPs. In retrospective evaluation, LLM module demonstrated...
Osteocalcin, a bone-derived protein, has recently been reported to affect energy metabolism. We investigated the relationship between serum osteocalcin and parameters of adiposity, glucose tolerance, lipid profile in Chinese subjects.Serum was measured by electrochemiluminescence immunoassay 254 men (128 with newly diagnosed type 2 diabetes mellitus (T2DM) 126 normal tolerance (NGT)), 66 premenopausal women (33 T2DM 33 NGT) as well 180 postmenopausal (92 88 NGT). Their associations were...
Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt analyze independent and joint effect of variants from these on clinical phenotypes related glucose metabolism.Twenty-one single nucleotide polymorphisms (SNPs) fourteen were successfully genotyped 1,849 subjects with 1,785 normal regulation. We analyzed allele genotype distribution between cases controls SNPs as well effects risk. The associations examined by...
Fibroblast growth factor (FGF) 21 is an endocrine actively involved in glucose and lipid metabolism rodents. However, little known about its physiological function regulation humans. This study investigated the diurnal changes circulating FGF21 concentrations their association with other metabolic markers both obese lean individuals.A total of 36 volunteers were assigned to 2 groups. One group received 3 standardized meals another was fasted for 24 h. Blood samples drawn every 30 min...
Although the pharmacological effects of fibroblast growth factor 21 (FGF21) are well-documented, uncertainty about its role in regulating excessive energy intake remains. Here, we show that FGF21 improves systemic insulin sensitivity by promoting healthy expansion subcutaneous adipose tissue (SAT). Serum levels positively correlate with SAT area insulin-sensitive obese individuals. knockout mice (FGF21KO) less mass and more insulin-resistant when fed a high-fat diet. Replenishment...
Melamine is converted to cyanuric acid by the gut microbe Klebsiella , leading melamine-cyanurate-urate coprecipitation that associated with nephrotoxicity.
<b>Objectives</b> To evaluate haemoglobin A1c (HbA<sub>1c</sub>) in diagnosing diabetes and identify the optimal HbA<sub>1c</sub> threshold to be used Chinese adults. <b>Design</b> Multistage stratified cross sectional epidemiological survey. <b>Setting</b> Shanghai, China, 2007-8. <b>Participants</b> 4886 adults over 20 years of age with no history diabetes. <b>Main outcome measures</b> Performance at increasing thresholds for <b>Results</b> The area under receiver operating characteristics...
The pathological development and the drug intervention of type 2 diabetes mellitus (T2DM) involve altered expression downstream low molecular weight metabolites including lipids amino acids, carbohydrates such as glucose. Currently, a small number markers used for clinical assessment T2DM treatment may be insufficient to reflect global variations in pathophysiology. In this study, metabonomic study was performed determine metabolic associated with treatments on 74 patients who were newly...
Obesity is not a homogeneous condition across individuals since about 25-40% of obese can maintain healthy status with no apparent signs metabolic complications. The simple anthropometric measure body mass index does always reflect the biological effects excessive fat on health, thus additional molecular characterizations phenotypes are needed to assess risk developing subsequent conditions at an individual level.To better understand associations free fatty acids (FFAs) obesity, we applied...