Elif I. Ekinci
A5006069892- Diabetes Management and Research
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Pancreatic function and diabetes
- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Dialysis and Renal Disease Management
- Diabetes Management and Education
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Advanced Glycation End Products research
- Renal Diseases and Glomerulopathies
- Chronic Disease Management Strategies
- Renal and Vascular Pathologies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Neurological and metabolic disorders
- Lipoproteins and Cardiovascular Health
- Nutrition and Health in Aging
Austin Health
2016-2025
The University of Melbourne
2016-2025
Mayo Clinic
2024
WinnMed
2024
Austin Hospital
2016-2024
Double Helix (United States)
2024
Parks Victoria
2024
Dicle University
2023
The Royal Melbourne Hospital
2022
St Vincent's Hospital
2005-2020
OBJECTIVE Many guidelines recommend that patients with type 2 diabetes should aim to reduce their intake of salt. However, the precise relationship between dietary salt and mortality in has not been previously explored. RESEARCH DESIGN AND METHODS Six hundred thirty-eight attending a single clinic were followed prospective cohort study. Baseline sodium excretion was estimated from 24-h urinary collections (24hUNa). The predictors all-cause cardiovascular determined by Cox regression...
The structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated. We compared biopsy findings and estimated glomerular filtration rate (eGFR) measured GFR <60 mL/min/1.73 m2, associated either normo-, micro-, or macroalbuminuria.In normo- (n = 8) microalbuminuria 6), biopsies were performed according a research protocol. In macroalbuminuria 17), clinical indication. Findings categorized the Fioretto classification: category 1 (C1),...
Finerenone reduced the risk of kidney and cardiovascular events in people with chronic disease (CKD) type 2 diabetes FIDELIO-DKD FIGARO-DKD phase 3 studies. Effects finerenone on outcomes patients taking sodium-glucose cotransporter inhibitors (SGLT2is) were evaluated a prespecified pooled analysis these studies.Patients urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m2 randomly assigned or placebo; SGLT2is permitted at...
Abstract Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary physicians (PCPs), particularly in low-resource settings. Here, bridge the gaps, we developed an integrated image–language system (DeepDR-LLM), combining large language model (LLM module) image-based deep learning (DeepDR-Transformer), provide individualized management recommendations PCPs. In retrospective evaluation, LLM module demonstrated...
NADPH oxidase–derived excessive production of reactive oxygen species (ROS) in the kidney plays a key role mediating renal injury diabetes. Pathological changes diabetes include mesangial expansion and accumulation extracellular matrix (ECM) leading to glomerulosclerosis. There is paucity data about Nox5 isoform oxidase animal models diabetic nephropathy since absent mouse genome. Thus, we examined human cells an inducible transgenic exposed streptozotocin-induced In biopsies, was identified...
Diabetic ketoacidosis (DKA) has been associated with the use of sodium glucose cotransporter 2 inhibitors (SGLT2is). To determine incidence, characteristics, and outcomes DKA in SGLT2i users vs nonusers type diabetes. Retrospective, multicenter, controlled cohort study. All public hospitals Melbourne Geelong (combined population 5 million), Australia, from 1 September 2015 to 31 October 2017. Consecutive cases that developed community, or during course hospital admission, patients diabetes...
The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury associated with a disruption in mitochondrial metabolic agility, inflammation, and fibrosis. We explored the role innate immune complement component C5a, potent mediator pathogenesis DKD clinical experimental diabetes. Marked systemic elevation C5a activity was demonstrated patients diabetes; conventional renoprotective agents did not...
In patients with chronic kidney disease (CKD) and type 2 diabetes (T2D), finerenone, a nonsteroidal mineralocorticoid receptor antagonist, reduces cardiovascular failure outcomes. Finerenone also lowers the urine albumin-to-creatinine ratio (UACR). Whether finerenone-induced change in UACR mediates outcomes is unknown.
Cystatin C-and creatinine-based methods were compared with (99m)-technetium-diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function.Glomerular (GFR) was monitored over a mean of 10.1 years in 85 subjects type 1 diabetes (with an average 5.6 measurements per individual). Baseline +/- SD iGFR the cohort 106.1 2.6 ml/min 1.73 m(2). The rates decline GFR (DeltaGFR) derived using linear regression.In...
Abstract Objective: To determine the prevalence of diabetes in inpatients Melbourne hospitals. Design: Point survey all each hospital on a single day between 30 November 2010 and 22 2012. Setting: 11 hospitals metropolitan including community, secondary tertiary one aged care rehabilitation centre. Participants: 2308 adult wards apart from intensive care, emergency, obstetrics psychiatry. Main outcome measures: self-reported diabetes, details current medication, frequency complications....