A5111855777- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Lipoproteins and Cardiovascular Health
- Physics of Superconductivity and Magnetism
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- melanin and skin pigmentation
- Autophagy in Disease and Therapy
- Environmental Impact and Sustainability
- Adipokines, Inflammation, and Metabolic Diseases
- Quantum and electron transport phenomena
- Caveolin-1 and cellular processes
- Cardiac Imaging and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Disease and Adiposity
- Advanced Glycation End Products research
- Plant-based Medicinal Research
- Parathyroid Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Agriculture Sustainability and Environmental Impact
- Alzheimer's disease research and treatments
- Redox biology and oxidative stress
- Cardiovascular Function and Risk Factors
- Retinal Diseases and Treatments
Beijing University of Technology
2025
Sun Yat-sen University
2013-2025
Third Affiliated Hospital of Sun Yat-sen University
2013-2025
Shanghai Sixth People's Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Xinjiang Institute of Materia Medica
2025
Xinjiang University
2025
Zhejiang Chinese Medical University
2024-2025
Hubei University
2023
Shanghai Ocean University
2023
Abstract Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide. The risk DR progression highly variable among different individuals, making it difficult to predict and personalize screening intervals. We developed validated a deep learning system (DeepDR Plus) time within 5 years solely from fundus images. First, we used 717,308 images 179,327 participants with diabetes pretrain system. Subsequently, trained multiethnic dataset comprising 118,868 29,868 diabetes....
Abstract Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary physicians (PCPs), particularly in low-resource settings. Here, bridge the gaps, we developed an integrated image–language system (DeepDR-LLM), combining large language model (LLM module) image-based deep learning (DeepDR-Transformer), provide individualized management recommendations PCPs. In retrospective evaluation, LLM module demonstrated...
Abstract Aims Fibroblast growth factor (FGF) 23 is a bone‐derived phosphaturic hormone that participates in the regulation of mineral metabolism and development chronic kidney disease. This study aimed to investigate association between FGF23 diabetic disease (DKD) community‐based prospective cohort. Materials Methods Of 7230 individuals who completed 4.6‐year follow‐up survey, 1614 with diabetes at baseline were included this study. Baseline serum levels measured by enzyme‐linked...
Purposes We have previously reported that Ginsenoside Rb1 may effectively prevent HUVECs from senescence, however, the detailed mechanism has not demonstrated up to now. Recent studies shown sirtuin-1 (Sirt1) plays an important role in development of endothelial senescence. The purpose this study was explore whether Sirt1 is involved action regarding protection against H2O2-induced HUVEC Senescence. Methods and Results Senescence induced by hydrogen peroxide (H2O2) human umbilical vein cells...
Node localization in two-dimensional (2D) and three-dimensional (3D) space for wireless sensor networks (WSNs) remains a hot research topic. To improve the accuracy applicability, we first propose quantum annealing bat algorithm (QABA) node WSNs. QABA incorporates evolution strategy into framework of to local global search capabilities, achieve balance with aid tournament natural selection, finally converge best optimized value. Additionally, use trilateral geometric feature principles...
Background: Extensive research has established obstructive sleep apnea (OSA) as a contributing factor to numerous cardiovascular and cerebrovascular diseases. However, whether OSA affects in-stent restenosis (ISR) after elective drug-eluting stenting is unclear. Therefore, the objective of this study was examine impact on ISR in patients with coronary heart disease (CHD) who underwent successful stent (DES) implantation. Methods: This retrospectively analyzed CHD successfully implantation...
BackgroundThe relationship between fibroblast growth factor 21 (FGF21) and sweet taste perception preference in type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate this examine the neural responses of T2DM patients high-calorie (HCS) food pictures, further exploring its correlation with FGF21 levels. MethodsWe assessed 40 41 controls using classical scales. Subsequently, 11 HCS pictures were examined functional magnetic resonance imaging. levels measured...
Improving the accessibility of screening diabetic kidney disease (DKD) and differentiating isolated nephropathy from non-diabetic (NDKD) are two major challenges in field diabetes care. We aimed to develop validate an artificial intelligence (AI) deep learning system detect DKD retinal fundus images. In this population-based study, we developed a image-based AI-deep system, DeepDKD, pretrained using 734 084 First, for detection, used 486 312 images 121 578 participants Shanghai Integrated...
Free fatty acids (FFAs) increase in visceral fat and are inferred to be one of the underlying inducers adipose tissue inflammation. In our previous study, it was demonstrated that ginsenoside Rb1 stimulates endothelial nitric oxide synthase (eNOS) Sirtuin 1 protect against cell senescence. present 3T3‑L1 adipocytes were exposed 0.5 mM FFAs with or without (10‑40 µM). Monocyte chemotactic protein‑1 (MCP‑1) interleukin‑6 (IL‑6) secretion measured using ELISA. Tumor necrosis factor‑α (TNF‑α)...
Oxidative low-density lipoprotein (ox-LDL) induces endothelium senescence and promotes atherosclerosis. Ginsenoside Rb1 (gRb1) has been proved to protect human umbilical vein cells (HUVECs), but its effect on ox-LDL-induced the underlying mechanism remains unknown. This study is explore involvement of SIRT1/Beclin-1/autophagy axis in gRb1 protecting against senescence. Hyperlipidemia Sprague Dawley rats was induced by high-fat diet, intraperitoneal injected. A model HUVECs ox-LDL also...
Multiferroic tunnel junctions (MFTJs) comprised of magnetic electrodes and a ferroelectric barrier have been emerging as promising candidates for nonvolatile memory applications. The recently discovered above room-temperature van der Waals (vdW) ferromagnet Fe3GaTe2 α-In2Se3 provides possibilities constructing vdW MFTJs. In this work, by using first-principles calculations, we investigate the spin-dependent transport in MFTJs with structure Fe3GaTe2/bilayer α-In2Se3/Fe3GaTe2. We predict...
Recent studies have shown that the critical currents of several metallic superconducting nanowires and Dayem bridges can be locally tuned by using a gate voltage (Vg). Here, we report gate-tunable Josephson junction structure constructed from three-dimensional (3D) niobium nanobridge (NBJ) with on top. Measurements up to 6 K showed current this zero increasing Vg. The was reduced 16 V may possibly further reducing thickness insulation layer between NBJ. Furthermore, flux modulation generated...
Abstract Adipose tissue inflammation is closely associated with the development of obesity and insulin resistance. Free fatty acids (FFAs) are a major inducer obesity-related Previously, we reported that endoplasmic reticulum (ER) stress potentially mediated retinal in diabetic retinopathy. The unfolded protein response (UPR) protects cells against damage induced by oxidative stress. X-box binding 1 (XBP1) plays role protecting modulating UPR. However, link between ER adipocyte has been...
Introduction Obesity is a complex and multifactorial disease that has affected many adolescents in recent decades. Clinical practice guidelines recommend exercise as the key treatment option for with overweight obesity. However, effects of virtual reality (VR) on physical brain health obese remain unclear. This study aims to evaluate VR exercises outcomes explore differences benefits between them. Moreover, we will apply multiomics analysis investigate mechanism underlying Methods randomised...
Abstract Superconducting memory cells that use flux quanta as their storage medium can achieve ultra-fast access times with ultra-low power consumption. However, the data signal generated by a quantum (FQM) cell is usually too weak and fast to be measured directly. Here, we present method characterize real-time operation of an FQM cell. The loop cell, configured Nb/NbN X /Nb Josephson junction, was proven capability store multiple quanta. readout demonstrated superconducting interference...
Abstract Storage of a single magnetic flux quantum in superconducting loop containing Josephson junction represents promising unit cell configuration for construction cryogenic memory digital circuits. However, application DC bias current is required operation such to maintain trapping the storage loop. In this work, we present that uses superconducting-magnetic π junction. The characteristics show hysteresis centering at zero-bias current. We develop fabrication process combines...
Recent studies and guidelines have indicated that lipoprotein(a) [Lp(a)]was an independent risk factor of arteriosclerotic cardiovascular disease (ASCVD). This study aimed to determine the relationship between serum Lp(a) levels periprocedural myocardial injury following percutaneous coronary intervention (PCI) in heartdisease (CHD) patients. enrolled 528 nonacute infarction (AMI) heart patients who successfully underwent PCI. Fasting lipids including were tested before High-sensitivity...