A5100743820- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Atmospheric chemistry and aerosols
- Organic Light-Emitting Diodes Research
- Atmospheric aerosols and clouds
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Retinal Imaging and Analysis
- Integrated Circuits and Semiconductor Failure Analysis
- Retinal Diseases and Treatments
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Semiconductor materials and devices
- Advanced biosensing and bioanalysis techniques
- Air Quality and Health Impacts
- Genomics and Chromatin Dynamics
- Advanced ceramic materials synthesis
- Medical Research and Treatments
- Organic Electronics and Photovoltaics
- CRISPR and Genetic Engineering
- Air Quality Monitoring and Forecasting
- Bone Metabolism and Diseases
Nanjing Tech University
2023-2025
Wuhan National Laboratory for Optoelectronics
2023-2024
Huazhong University of Science and Technology
2023-2024
Shanghai Jiao Tong University
2024
Shanghai Sixth People's Hospital
2024
University College Cork
2023
Cambridge Crystallographic Data Centre
2023
Atrium Health Wake Forest Baptist
2023
Nankai University
2023
Shanghai Huali Microelectronics (China)
2022-2023
Abstract Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide. The risk DR progression highly variable among different individuals, making it difficult to predict and personalize screening intervals. We developed validated a deep learning system (DeepDR Plus) time within 5 years solely from fundus images. First, we used 717,308 images 179,327 participants with diabetes pretrain system. Subsequently, trained multiethnic dataset comprising 118,868 29,868 diabetes....
Abstract Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary physicians (PCPs), particularly in low-resource settings. Here, bridge the gaps, we developed an integrated image–language system (DeepDR-LLM), combining large language model (LLM module) image-based deep learning (DeepDR-Transformer), provide individualized management recommendations PCPs. In retrospective evaluation, LLM module demonstrated...
Catalpol, an iridoid glycoside, exists in the root of Radix Rehmanniae. Some studies have shown that catalpol has a remarkable hypoglycemic effect streptozotocin-induced diabetic model, but underlying mechanism for this not been fully elucidated. Because mitochondrial dysfunction plays vital role pathology diabetes and because improving function may offer new approach treatment diabetes, study was designed. Catalpol orally administered together with metformin to high-fat diet/streptozotocin...
Ferroptosis is one critical kind of regulated cell death for tumor suppression, yet it still presents challenges low efficiency due to the intracellular alkaline pH and aberrant redox status. Herein, we reported a carbonic anhydrase IX (CA IX)-targeted nanovesicle (PAHC NV) potentiate ferroptosis by remodeling environment. CA inhibitor 4-(2-aminoethyl) benzene sulfonamide (AEBS) was anchored onto nanovesicles loaded with hemoglobin (Hb) chlorin e6 (Ce6). Upon reaching regions, PAHC could be...
Multi-resonant thermally activated delayed fluorescence (MR-TADF) materials have stirred up a wave in the field of organic light-emitting diodes (OLEDs). However, there remains significant room for improvement regarding concentration...
It is well-recognized that metal ion contaminants present in food and the environment pose a serious threat to human health contribute huge economic losses. Therefore, development of simple, rapid, sensitive, on-site methods for detection ions has become an urgent need. Herein, we combined isothermal hybridization chain reaction (HCR) DNAzyme develop dual-signal amplification sensing assay ultrasensitive Mg2+ on microplates. In this assay, linker DNA strand (LDNA) triggered formation HCR...
Abstract Due to higher exciton energy, the deep‐blue organic light‐emitting diodes (OLEDs) are most challenging among trichromatic emitters. In this work, three novel blue emitters with multi‐resonance (MR) effects reported based on N , ,5,9‐tetraphenyl‐5,9‐dihydro‐5,9‐diaza‐13b‐boranaphtho[3,2,1‐ de ]anthracen‐7‐amine (PAB) skeleton, incorporating fluorine and methyl groups. Compound 2FPAB MePAB exhibit ultra‐pure emission peaks at 436 448 nm respectively. The device achieves a maximum...
Strategies based on nanomaterials for sterilization address the problem of antibiotic resistance faced by conventional antimicrobials, with contribution photocatalytic compounds being particularly prominent. Herein, to integrate multiple bactericidal techniques into a system generating synergistic antibacterial effects, novel photo-triggered AuAg@g-C
The ratiometric sensing strategy, which uses dual-signal output, drastically compensates for the background noise and interference from detection environment, compared to methods that rely on a single-signal output.
High-energy vacuum microwave irradiation was directly applied to synthesize silicon carbide (SiC). Results indicated that the well-crystallized β-SiC grains can be obtained rapidly and conveniently via approach, even simply constituents covering silica dioxide powders artificial graphite were employed as raw materials. Based on comprehensive micro-structural characterizations, formation of β-SiC, under high-energy irradiation, could properly explained by mechanism two-dimension nucleation...
To address the requirement of ultra-sensitive detection trace mercury(II) (Hg
Abstract. Water uptake abilities of organic aerosol under sub-saturated conditions play critical roles in direct radiative effects and atmospheric chemistry, however, field characterizations hygroscopicity parameter κOA remain limited. In this study, a campaign was conducted to characterize at relative humidity 80 % with hourly time resolution for the first Pearl River Delta region China. Observation results show that during secondary (SOA) dominated total mass (mass fraction >70 on...
Abstract. The contribution of new particle formation (NPF) to cloud condensation nuclei (CCN) number concentration varies largely under different environments, depending on several key factors such as rate (J), growth (GR), distribution preexisting particles and properties during NPF events. This study investigated the NCCN its controlling based measurements conducted at Heshan supersite, in Pearl River Delta (PRD) region China fall-time 2019. size-resolved activity hygroscopicity were...
Intracellular-synthesized chemo-drugs based on the inherent characteristics of tumor microenvironment (TME) have been extensively applied in oncotherapy. However, combining other therapeutic strategies to convert nontoxic small molecules into toxic small-molecule TME is still a huge challenge. To address this issue, herein we developed biomimetic dual-responsive bioengineered nanotheranostics system via supramolecular co-assembly 1,5-dihydroxynaphthalene (DHN) and photosensitizer indocyanine...
A facile method to fabricate Au-CdS (or ZnS, PbS) nanocomposites is reported. The based on spontaneous growth of Au onto the metal sulfide nanoparticles. Unlike typical synthesis Au- semiconductor nanocomposites, this does not require additional steps introducing other reducing agents. Direct redox reactions occurs between Au(III) ions and We have probed Au-semiconductor by scanning electron microscopy (SEM), transmission (TEM), X-ray diffraction (XRD). possible mechanism was proposed for It...
Lots of basic analyses carried on YJOS (Yaojie oil shale) and LKOS (Longkou consist proximate analysis, ultimate XRF analysis shale yield in aluminum retort. Besides, TGA are used , oil, gas chromatographic is retorting gas. The results show that have the same hydrogen-to-carbon ratio, but has higher volatile component its retort much than . Ca content however, Al Fe lower Two kinds after destructive distillation similar composition relative content, addition, they all produce more low...
<div>Abstract<p>When recruited to promoters, histone 3 lysine 4 (H3K4) methyltransferases KMT2 (KMT2A-D) activate transcription by opening chromatin through H3K4 methylation. Here, we report that <i>KMT2</i> mutations occur frequently in non–small cell lung cancer (NSCLC) and are associated with high mutation loads poor survival. KMT2C regulated DNA damage responses (DDR) direct recruitment sites Ago2 small noncoding response RNA, where it mediates methylation,...
<div>Abstract<p>When recruited to promoters, histone 3 lysine 4 (H3K4) methyltransferases KMT2 (KMT2A-D) activate transcription by opening chromatin through H3K4 methylation. Here, we report that <i>KMT2</i> mutations occur frequently in non–small cell lung cancer (NSCLC) and are associated with high mutation loads poor survival. KMT2C regulated DNA damage responses (DDR) direct recruitment sites Ago2 small noncoding response RNA, where it mediates methylation,...