A5042254050- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Genetic factors in colorectal cancer
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Electromagnetic Fields and Biological Effects
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Genetics and Neurodevelopmental Disorders
- Peptidase Inhibition and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- BRCA gene mutations in cancer
- Pancreatic function and diabetes
- RNA modifications and cancer
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
Wayne State University
2024-2025
The Barbara Ann Karmanos Cancer Institute
2024-2025
Atrium Health Wake Forest Baptist
2015-2024
Michigan United
2024
University of Alabama at Birmingham
2008-2023
Wake Forest University
2014-2023
Wake Forest Baptist Comprehensive Cancer Center
2016-2023
Weatherford College
2021
Prisma Health
2021
U-M Rogel Cancer Center
2019
All cancers develop as a result of mutations in certain genes, such those involved the regulation cell growth and/or DNA repair, 1,2 but not all these are inherited from parent.For example, sporadic can occur somatic/ tumor cells only, and de novo for first time germ (i.e., egg or sperm) fertilized itself during early embryogen-
Up to 30% of patients with metastatic breast cancer eventually develop brain metastasis, yet the pathologic mechanism behind this development remains poorly understood. Here, we profiled long noncoding RNAs in tumors from and found that X-inactive-specific transcript (XIST) was significantly downregulated these tissues. XIST expression levels inversely correlated but not bone metastasis patients. Silencing preferentially promoted growth
MUC16, which encodes cancer antigen 125 (CA-125), is frequently mutated in gastric (GC); however, its association with tumor mutation load (TML) and outcome patients GC has not been established, to date.To investigate whether MUC16 mutations are associated TML prognosis GC.Statistical analysis of genomic data from 437 samples obtained The Cancer Genome Atlas (TCGA) 256 an Asian cohort. Both cohorts contained involved previous studies. Data were TCGA on September 3, 2017, the cohort March 5,...
In early pancreatic carcinogenesis, TGFβ acts as a tumor suppressor due to its growth-inhibitory effects in epithelial cells. However, advanced disease, appears promote progression. Therefore, better understand the contributions of signaling we generated mouse models cancer with either or systemic TGFBR deficiency. We found that suppression signals facilitated tumorigenesis, whereas global loss protected against development via inhibition tumor-associated fibrosis, stromal TGFβ1 production,...
During the past few years, several genetic aberrations that may contribute to increased risks for development of breast and/or ovarian cancers have been identified. The NCCN Guidelines Genetic/Familial High-Risk Assessment: Breast and Ovarian focus specifically on assessment mutations in BRCA1/BRCA2, TP53, PTEN, recommend approaches testing/counseling management strategies individuals with these mutations. This portion includes recommendations regarding diagnostic criteria patients Cowden...
Obesity has been shown to increase breast cancer risk. FTO is a novel gene which identified through genome wide association studies (GWAS) be related obesity. Our objective was evaluate tissue expression of in and the role SNPs predicting We performed case-control study 354 cases 364 controls. This conducted at Northwestern University. examined single nucleotide polymorphisms (SNPs) intron 1 genotyped controls for four SNPs: rs7206790, rs8047395, rs9939609 rs1477196. also evaluated normal...
Much of the genetic predisposition to colorectal cancer (CRC) in humans is unexplained. Studying a Caucasian-dominated population United States, we showed that germline allele-specific expression (ASE) gene encoding transforming growth factor-beta (TGF-beta) type I receptor, TGFBR1, quantitative trait occurs 10 20% CRC patients and 1 3% controls. ASE results reduced gene, dominantly inherited, segregates families, sporadic cases. Although subtle, reduction constitutive TGFBR1 alters...
Abstract Purpose Because in vitro studies suggest that low levels of electromagnetic fields may modify cancer cell growth, we hypothesized systemic delivery a combination tumor-specific frequencies have therapeutic effect. We undertook this study to identify and test the feasibility administering such patients with advanced cancer. Patients methods examined various types using noninvasive biofeedback method frequencies. offered compassionate treatment some limited options. Results total 163...
There is clinical evidence that very low and safe levels of amplitude-modulated electromagnetic fields administered via an intrabuccal spoon-shaped probe may elicit therapeutic responses in patients with cancer. However, there no known mechanism explaining the anti-proliferative effect intensity fields.To understand this novel approach, hepatocellular carcinoma (HCC) cells were exposed to 27.12 MHz radiofrequency using vitro exposure systems designed replicate vivo conditions. Cancer...
Tumor-infiltrating myeloid cells are the most abundant leukocyte population within tumors. Molecular cues from tumor microenvironment promote differentiation of immature toward an immunosuppressive phenotype. However, in situ dynamics transcriptional reprogramming underlying this process poorly understood. Therefore, we applied single cell RNA-seq (scRNA-seq) to computationally investigate cellular composition and adjacent normal tissues 4 early-stage non-small lung cancer (NSCLC) patients....
Abstract Brain metastasis is one of the chief causes mortality in breast cancer patients, but mechanisms that drive this process remain poorly understood. Here, we report brain metastatic cells expressing high levels c-Met promote via inflammatory cytokine upregulation and vascular reprogramming. Activated signaling promoted adhesion tumor to endothelial enhanced neovascularization by inducing secretion IL8 CXCL1. Additionally, stimulation IL1β activation induced tumor-associated astrocytes...
Breast cancer risk is higher among obese women and with diabetes. Adiponectin a protein exclusively secreted by adipose tissue, circulating levels of which have been associated breast risk. Whether genetic variants within the adiponectin pathway are unknown. To explore association (ADIPOQ) receptor 1 (ADIPOR1) genes risk, we conducted case control study female patients healthy controls from New York City recruited between 1999 2004. We genotyped 733 hospital-based cases 839 for 10...