A5011443826- Cancer, Stress, Anesthesia, and Immune Response
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- FOXO transcription factor regulation
- Immune cells in cancer
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
- Nicotinic Acetylcholine Receptors Study
- Bone health and treatments
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone and Dental Protein Studies
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
Wake Forest University
2016-2025
University of North Carolina at Greensboro
2024-2025
Atrium Health Wake Forest Baptist
2016-2024
Shanghai East Hospital
2023-2024
Weatherford College
2021
Shandong University of Technology
2020
Centre for Cancer Biology
2016
University of Mississippi Medical Center
2013
University of Mississippi
2013
Iwate Medical University
2013
Up to 30% of patients with metastatic breast cancer eventually develop brain metastasis, yet the pathologic mechanism behind this development remains poorly understood. Here, we profiled long noncoding RNAs in tumors from and found that X-inactive-specific transcript (XIST) was significantly downregulated these tissues. XIST expression levels inversely correlated but not bone metastasis patients. Silencing preferentially promoted growth
Abstract Despite significant improvement in survival rates of patients with breast cancer, prognosis metastatic disease is still dismal. Cancer stem-like cells (CSC) are considered to play a role progression cancer; however, the exact pathologic CSCs yet be elucidated. In this report, we found that (CD24−/CD44+/ESA+) isolated from cell lines significantly more than non-CSC populations an organ-specific manner. The results our microRNA (miRNA) profile analysis for these revealed highly bone...
Smoking has a profound impact on tumor immunity, and nicotine, which is the major addictive component of smoke, known to promote progression despite being non-carcinogen. In this study, we demonstrate that chronic exposure nicotine plays critical role in formation pre-metastatic niche within lungs by recruiting pro-tumor N2-neutrophils. This promotes release STAT3-activated lipocalin 2 (LCN2), secretory glycoprotein from N2-neutrophils, induces mesenchymal-epithelial transition cells thereby...
Abstract Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients with estrogen-positive tumors experience a significantly higher incidence bone (>87%) compared to estrogen-negative (<56%). To understand the mechanism this bone-tropism ER + tumor, and identify liquid biopsy biomarkers for high risk metastasis, secreted extracellular vesicles cytokines from bone-tropic cancer cells are examined in study. Both exosomal miR-19a Integrin-Binding...
Research Article5 March 2013Open Access Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain Fei Xing Department Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School Medicine, Springfield, IL, USA Cancer Institute, Mississippi Center, Jackson, MS, Search for more papers this author Aya Kobayashi Hiroshi Okuda Misako Watabe Sudha K. Pai Puspa R. Pandey Shigeru Hirota Internal Iwate...
Abstract Brain metastasis is one of the chief causes mortality in breast cancer patients, but mechanisms that drive this process remain poorly understood. Here, we report brain metastatic cells expressing high levels c-Met promote via inflammatory cytokine upregulation and vascular reprogramming. Activated signaling promoted adhesion tumor to endothelial enhanced neovascularization by inducing secretion IL8 CXCL1. Additionally, stimulation IL1β activation induced tumor-associated astrocytes...
Prostate cancer is known to frequently recur in bone; however, how dormant cells switch its phenotype leading recurrent tumor remains poorly understood. We have isolated two syngeneic cell lines (indolent and aggressive) through vivo selection by implanting PC3mm stem-like into tibial bones. found that indolent retained the phenotype, whereas aggressive grew rapidly bone vivo, growth rates of both culture were similar, suggesting a role microenvironment regulation dormancy recurrence....
Up to 40% of lung cancer patients develop brain metastasis, and the median survival these remains less than 6 months. Smoking is associated with cancer. However, how smoking impacts development metastasis elusive. We examined 281 distant found that smokers exhibited a significantly high incidence metastasis. nicotine enhanced while depletion microglia suppressed this effect in vivo. Nicotine skewed polarity M2 phenotype, thereby increasing secretion IGF-1 CCL20, which promoted tumor...
Abstract Smoking is associated with lung cancer and has a profound impact on tumor immunity. Nicotine, the addictive non-carcinogenic smoke component, influences various brain cells immune system. However, how long-term use of nicotine affects metastases poorly understood. We, therefore, examined mechanism by which promotes metastasis. In this study, we conducted retrospective analysis 810 patients smoking history assessed We found that current smoker’s have significantly higher metastatic...
Brain metastases are a major cause of death in patients with metastatic breast cancer. While surgical resection and radiation therapy effective treatment modalities, the majority will succumb from disease progression. We have developed novel for brain that delivers athermal radiofrequency electromagnetic fields amplitude-modulated at cancer specific frequencies (BCF).27.12 MHz BCF were administered to patient metastasis by placing spoon-shaped antenna on anterior part tongue three one-hour...
Breast cancer has been shown to be resistant immunotherapies. To overcome this challenge, we developed an active immunotherapy for personalized treatment based on a smart nanovesicle. This is achieved by anchoring membrane-bound bioactive interleukin 2 (IL2) and enriching T cell-promoting costimulatory factors the surface of dendritic cell-derived small extracellular vesicles. nanovesicle also displays major histocompatibility complex-bound antigens inherited from tumor lysate-pulsed cell....
Abstract We aimed to restore MHC-I expression on the surface of solid tumors including breast cancer and melanoma cells regain sensitivity immunotherapy suppress metastatic progression. screened a natural compound library identified macbecin II as reagent that upregulates induces antigen-dependent cell death in pre-invasive invasive models. Furthermore, we employed active using engineered small extracellular vesicles from dendritic (DCs) tumor vaccine (IL2-ep13nsEV) combination with for...
Abstract Breast cancer displays disparities in mortality between African Americans and Caucasian Americans. However, the exact molecular mechanisms remain elusive. Here, we identify miR-1304-3p as most upregulated microRNA American patients. Importantly, its expression significantly correlates with poor progression-free survival Ectopic of miR-1304 promotes tumor progression vivo. Exosomal activates cancer-associated adipocytes that release lipids enhance cell growth. Moreover,...
Abstract Background Brain metastasis of breast cancer exhibits exceedingly poor prognosis, and both triple negative (TN) Her2 + subtypes have the highest incidence brain metastasis. Although estrogen blockers are considered to be ineffective for their treatment, recent evidence indicates that blockade using tamoxifen showed certain efficacy. However, how affects (TNBC) remains elusive. Methods To examine effect on progression, nude mice were implanted with metastatic cells treated either...
Ethnicity is considered to be one of the major risk factors in certain subtypes breast cancer. However, mechanism this racial disparity remains poorly understood. Here, we demonstrate that SOS1, a key regulator Ras pathway, highly expressed African-American (AA) patients with cancer compared Caucasian-American patients. Because higher obesity rate AA women, increased levels SOS1 facilitated signal transduction c-Met which was activated via hepatocyte growth factor secreted from adipocytes....
Abstract Background Ductal carcinoma in situ (DCIS) of breast is the noninvasive lesion that has propensity to progress malignant form. At present, it still unknown which lesions can potentially invasive forms. In this study, we aimed identify key lncRNAs involved DCIS growth. Methods We employ disease-related lncProfiler array IPW specimens and matching control samples validate observations three DCIS-non-tumorigenic cell lines. Further, examine mechanism action downstream signaling vitro...