A5071463713- Cancer, Hypoxia, and Metabolism
- Mechanisms of cancer metastasis
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Cancer Cells and Metastasis
- Protein Kinase Regulation and GTPase Signaling
- Fibroblast Growth Factor Research
- Pregnancy and preeclampsia studies
- Proteoglycans and glycosaminoglycans research
- Bone health and treatments
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Birth, Development, and Health
- Brain Metastases and Treatment
- Reproductive System and Pregnancy
- Cancer Mechanisms and Therapy
- Chemokine receptors and signaling
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Gestational Trophoblastic Disease Studies
- CAR-T cell therapy research
Tokushima University
2024
Dana-Farber Cancer Institute
2018-2022
Harvard University
2022
Broad Institute
2019-2022
Astellas Pharma (Japan)
2018
Wakayama Medical University
2011-2017
Kyoto University
2006-2016
Wake Forest University
2015
Southern Illinois University School of Medicine
2008-2013
Iwate Medical University
2011
SNF'ing out antitumor immunity Immune checkpoint inhibitors induce durable tumor regressions in some, but not all, cancer patients. Understanding the mechanisms that determine sensitivity to these drugs could potentially expand number of patients who benefit (see Perspective by Ghorani and Quezada). Pan et al. discovered cells which a specific SWI/SNF chromatin remodeling complex had been experimentally inactivated were more sensitive T cell–mediated killing. The responsive interferon-γ,...
Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant organs are a critical issue. However, how metastatic tumor cells become dormant why recur in target not well understood. In this study, we demonstrate that BMP7 (bone morphogenetic protein 7) secreted from bone stromal induces senescence prostate stem-like (CSCs) by activating p38 mitogen-activated kinase increasing expression cell cycle inhibitor, p21, metastasis suppressor gene, NDRG1 (N-myc...
Cholesterol and phospholipids are essential to the body, but an excess of cholesterol or lipids is toxic a risk factor for arteriosclerosis. ABCG1, one half-type ABC proteins, thought be involved in homeostasis. To explore role ABCG1 homeostasis, we examined its subcellular localization function. ABCG1-K120M, WalkerA lysine mutant, were localized plasma membrane HEK293 cells stably expressing formed homodimer. A stable transformant exhibited efflux choline presence BSA, was enhanced by HDL,...
The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here, we report upregulation of hyaluronan synthase 2 (HAS2) occurs in highly breast cancer stem-like cells (CSC) defined by CD44(+)/CD24(-)/ESA(+) phenotype, where it plays a critical role generation prometastatic cancer. HAS2 was for interaction CSCs with tumor-associated macrophages (TAM), leading enhanced secretion platelet-derived growth factor-BB from TAMs, which...
Research Article5 March 2013Open Access Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain Fei Xing Department Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School Medicine, Springfield, IL, USA Cancer Institute, Mississippi Center, Jackson, MS, Search for more papers this author Aya Kobayashi Hiroshi Okuda Misako Watabe Sudha K. Pai Puspa R. Pandey Shigeru Hirota Internal Iwate...
Abstract RhoC is a member of the Ras-homologous family genes which have been implicated in tumorigenesis and tumor progression. However, exact role controversial yet to be clarified. We examined effect on prostate cells found that had no cell proliferation vitro or growth mice. significantly enhanced metastatic ability these animals, suggesting affects only metastasis but not cells. The results our immunohistochemical analyses specimens from 63 patients with cancer indicate expression...
The objective of this study was to investigate the preoperative diagnostic value F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography and computed (PET/CT) in patients with ovarian cancer.One hundred sixty suspected having malignant tumors were included study. All underwent FDG-PET/CT scans before operation, maximum standardized uptake (SUVmax) primary tumor measured. We evaluated accuracy SUVmax for detecting malignancy its relationship histological findings.Postoperative...
NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the dissemination of tumor cells from primary tumors distant organs. Previously, we identified promoting transcription factor, ATF3, as a downstream target NDRG1. Further analysis revealed that promoter contained consensus binding motif suggesting possibility suppresses through inhibition ATF3 expression followed by activation gene. In this report, found ectopic was able augment endogenous gene in prostate cancer cell lines,...
Chronic abruption-oligohydramnios sequence (CAOS) is a clinical condition with lasting vaginal bleeding and oligohydramnios because of chronic placental abruption, which seems to cause preterm labor neonatal lung disease (CLD). This prompted us explore the correlation between perinatal/neonatal outcomes CAOS.Patients suspected risk abortion recurrent were divided into CAOS non-CAOS groups, we compared these two groups. To examine impact chorioamnionitis (CAM) on prognosis CAOS, also group...
Abstract Human ABCB4 (multidrug resistance [MDR]3 P-glycoprotein) is expressed in the canalicular membrane of hepatocyte. has been shown to be required for phosphatidylcholine (PC) secretion into bile and translocate PC across plasma membrane. To further investigate function ABCB4, we established a cell line stably expressing (human embryonic kidney [HEK]/ABCB4). The efflux phospholipids from HEK/ABCB4 cells was remarkably increased by addition taurocholate. In addition, cholesterol also...
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that has immunoregulatory functions. Our prior study showed tumoral IDO overexpression involved in disease progression and impaired patient survival human ovarian cancer, although its mechanism remains unclear. The purpose of the present to clarify role during process peritoneal dissemination cancer. cDNA was transfected into murine carcinoma cell line OV2944-HM-1, establishing stable clones IDO-overexpressing cells...
ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates efflux cholesterol to HDL and functions in reverse transport from peripheral cells liver. We have shown that ABCG1 not only but also sphingomyelin (SM) phosphatidylcholine. Because SM preferentially associates with cholesterol, we examined whether it plays an important role ABCG1-mediated cholesterol. The mediated by was reduced a mutant CHO-K1 cell line, LY-A, which cellular level is because mutation ceramide transfer...
ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons glia the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between level system Alzheimer’s disease has been reported. In this study, we examined effects of ABCG1 ABCG4 on amyloid precursor protein (APP) processing, product which, β (Aβ), is involved pathogenesis disease. Expression or human embryonic kidney 293 cells that stably Swedish-type mutant APP increased cellular cell surface...
ATP-binding cassette A1 (ABCA1), ABCG1, and ABCG4 are lipid transporters that mediate the efflux of cholesterol from cells. To analyze characteristics these transporters, we examined compared their distributions activity on plasma membrane. The mediated by ABCA1 but not ABCG4, was affected a reduction cellular sphingomyelin levels. Detergent solubility gradient density ultracentrifugation assays indicated ABCA1, were distributed to domains solubilized Triton X-100 Brij 96, resistant...
Major challenges to chimeric antigen receptor (CAR) T cell therapies include uncontrolled immune activity, off-tumor toxicities and tumor heterogeneity. To overcome these challenges, we engineered CARs directed against small molecules. By conjugating the same molecule distinct tumor-targeting antibodies, show that specific-CAR cells can be redirected different antigens. Such binary switches allow control over degree of CAR activity enables simultaneous targeting multiple tumor-associated We...
Human ABCG subfamily proteins ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8 are half-type ATP-binding cassette (ABC) that transport sterols or xenobiotics. ABCG4 function as homodimers on the plasma membrane. In contrast, ABCG5 heterodimers membrane, homodimer of either is retained in endoplasmic reticulum (ER). To examine molecular mechanisms regulated trafficking ABCG8, subcellular localizations chimeric proteins, fused with ABCG1 were analyzed. Homodimers which N-terminal cytosolic domain ABCG2...
Large-cell neuroendocrine carcinoma (LCNEC) is a high-grade tumor. LCNECs arising from the genital organs are highly malignant and rare, with <20 cases of LCNEC developing uterine endometrium reported to date. We herein present case patient endometrium. The was 52-year-old woman, who exhibited lower abdominal pain rapid enlargement during outpatient treatment for myoma. endometrial biopsy suggested diagnosis poorly differentiated or carcinosarcoma. Based on magnetic resonance imaging...
Abstract Aim We aimed to investigate maternal serum angiogenic marker profiles within 1 week prior delivery in cases of gestational hypertension (GH), pre‐eclampsia (PE), and/or fetal growth restriction (FGR) with different clinical conditions. Methods enrolled 165 women singleton pregnancy. The participants were classified based on three characteristics: (i) proteinuria (GH and PE); (ii) FGR (PE [PE + FGR], PE alone, alone); (iii) onset (early [EO PE] late‐onset [LO PE]). All sera obtained...
The aim of this study was to clarify the clinicopathologic factors stages IB IIB cervical adenocarcinoma.Several were compared between 35 patients who underwent radical hysterectomy and pelvic lymphadenectomy due adenocarcinoma 77 with squamous cell carcinoma (SCC).In adenocarcinoma, univariate analysis demonstrated that International Federation Gynecology Obstetrics stage, tumor size, lymphovascular space invasion significantly associated progression-free survival (PFS), whereas FIGO...