A5005625979- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Proteoglycans and glycosaminoglycans research
- Fibroblast Growth Factor Research
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Tumors and Oncological Cases
- Genetics, Bioinformatics, and Biomedical Research
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Metastasis and carcinoma case studies
- Advanced Breast Cancer Therapies
- Histone Deacetylase Inhibitors Research
- Mechanisms of cancer metastasis
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
Medpace (United States)
2024
University of Cincinnati
2017-2023
Cincinnati Children's Hospital Medical Center
2017-2022
Southern Illinois University School of Medicine
2011-2016
Iwate Medical University
2011
Novartis (Switzerland)
2007-2010
Radboud University Medical Center
2010
Imperial College London
2010
Radboud University Nijmegen
2010
Hershey (United States)
2007
The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here, we report upregulation of hyaluronan synthase 2 (HAS2) occurs in highly breast cancer stem-like cells (CSC) defined by CD44(+)/CD24(-)/ESA(+) phenotype, where it plays a critical role generation prometastatic cancer. HAS2 was for interaction CSCs with tumor-associated macrophages (TAM), leading enhanced secretion platelet-derived growth factor-BB from TAMs, which...
NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the dissemination of tumor cells from primary tumors distant organs. Previously, we identified promoting transcription factor, ATF3, as a downstream target NDRG1. Further analysis revealed that promoter contained consensus binding motif suggesting possibility suppresses through inhibition ATF3 expression followed by activation gene. In this report, found ectopic was able augment endogenous gene in prostate cancer cell lines,...
Anti-tumor immune responses impede tumor formation, and cancers have evolved many mechanisms of evasion. Confirming earlier findings, we show that human tumors with high chromosomal instability (CIN+) are significantly less immunogenic, as judged by lymphocyte infiltration, compared to those more stable genomes (CIN-). This finding is paradoxical, genomic expected evoke an innate response. Importantly, CIN+ cell lines exhibited suppressed expression proteins involved in MHC class I antigen...
Background Cancer immunotherapy has taken center stage in cancer treatment. However, the current immunotherapies only benefit a small proportion of patients with cancer, necessitating better understanding mechanisms tumor immune evasion and improved strategies. Regulatory T (Treg) cells play an important role maintaining tolerance through inhibiting effector T-cell function. In microenvironment, Treg are used by to counteract cell-mediated suppression. Targeting may thus unleash antitumor...
Platinum-based therapy is most often used to treat advanced cases of head and neck cancers, but only a small fraction the patient population responds cisplatin, with median survival time less than year. Although gene signatures molecular etiology cancers have been previously described, none them are predictive indicators cisplatin treatment response in particular. Therefore, currently, there lack clinically employable disease beyond HPV status specifically predict patients' platinum-based...
The nature and role of global transcriptional deregulations in cancers are not fully understood. We report that a large proportion have widespread defects mRNA transcription elongation (TE). Cancers with TE (TE
The loss of RAB25 expression-RAS superfamily GTPase characteristic numerous breast cancers-corresponds with H-RAS point mutations, particularly in triple-negative cancers (TNBC), a subtype associated poor prognosis. To address the poorly understood factors dictating progression TNBC tumors, we examine cooperative effects that expression human mammary epithelial cell (HMEC) lines mutations confers tumorigenesis. HMECs were immortalized by transduction LXSN CDK4 R24C, mutant form...
Primary human mammary epithelial cells have a limited life span which makes it difficult to study them in vitro for most purposes. To overcome this problem, we developed cell line that was immortalized using defined genetic elements, and characterized non-tumorigenic establish as potential model system. were obtained from healthy individual undergoing reduction mammoplasty at SIU School of Medicine. The transduced with CDK4R24C followed by transduction telomerase reverse transcriptase. Post...
RhoA of the Rho GTPase family is prenylated at its C-terminus. Prenylation has been shown to control T helper 17 (Th17) cell-mediated colitis. By characterizing cell-specific conditional knockout mice, we have recently that required for Th2 and Th17 cell differentiation Th2/Th17 allergic airway inflammation. It remains unclear whether plays a cell-intrinsic role in regulatory (Treg) cells suppress effector such as maintain immune tolerance promote tumor evasion. Here generated Treg...
10591 Background: Macrophage colony stimulating factor (M-CSF) and its receptor (CSF-1R, the c-fms oncogene protein product) have been reported to be expressed in a variety of cancers, including breast cancer. The M-CSF produced by cancer cells surrounding stromal increases osteoclast formation maturation enhances expression RANK ligand, both which increase osteolytic bone degradation. In this study we evaluated predictive prognostic potential circulating metastatic patients treated with...
The clinical response to immune checkpoint blockade (ICB) correlates with tumor-infiltrating cytolytic T lymphocytes (CTLs) prior treatment. However, many of these inflamed tumors resist ICB through unknown mechanisms. We show that transcription elongation deficiencies (TEdef+), which we previously reported as being resistant in mouse models and the clinic, have high baseline CTLs. CTLs TEdef+ result from aberrant activation nucleic acid sensing-TBK1-CCL5/CXCL9 signaling cascade, results an...
Abstract Introduction: Head and neck cancers are usually detected in their later stages of progression, resulting a 5-year survival rate only 30-50%. Chemotherapy is treatment choice for locally advanced head squamous cellular carcinoma (HNSCC), unfortunately, subset HNSCC responds favorably to cisplatin treatment. Currently, there no predictive markers tumor's response therapy. Therefore, investigate the extremely low rates durable remission HNSCC, we employed method screening membrane...
Abstract Background: Data from this pre-clinical model suggests that the LAR TNBC subtype is unique and may respond to novel hormonal agents such as bicalutamide or abiraterone. The represents 11 % of all (which represent 20% breast cancers). Thus, positive studies abiraterone could potentially extend application an additional 2% cancer patients, who be treated in metastatic, neoadjuvant, adjuvant setting (for five years) with maintenance therapy. We, therefore, conducted on cell line,...
Abstract Introduction: Head and neck cancers are usually detected in its later stages of progression, resulting a 5-year survival rate only 30-50%. Chemotherapy is the treatment choice for locally advanced head squamous cellular carcinoma (HNSCC), unfortunately, subset HNSCC responds favorably to cisplatin treatment. Currently, there no predictive markers tumor's response therapy. Therefore, investigate extremely low rates HNSCC, we employed method screening membrane bound surface stem cell...
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<div>Abstract<p>The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here, we report upregulation of hyaluronan synthase 2 (HAS2) occurs in highly breast cancer stem–like cells (CSC) defined by CD44<sup>+</sup>/CD24<sup>−</sup>/ESA<sup>+</sup> phenotype, where it plays a critical role generation prometastatic cancer. HAS2 was for interaction CSCs with tumor-associated...
<div>Abstract<p>The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here, we report upregulation of hyaluronan synthase 2 (HAS2) occurs in highly breast cancer stem–like cells (CSC) defined by CD44<sup>+</sup>/CD24<sup>−</sup>/ESA<sup>+</sup> phenotype, where it plays a critical role generation prometastatic cancer. HAS2 was for interaction CSCs with tumor-associated...
Abstract Introduction: Cisplatin is an important chemotherapeutic agent, which has resulted in higher overall response rates when combined with 5-FU or taxane combinations treating squamous cellular carcinoma of the head and neck. However, HNSCC tumor to cisplatin range from 20-30%, a major clinical hurdle today. To address this issue thoroughly, we investigated resistance under purview cancer stem cell hypothesis, using widely studied CSC marker of, CD44+ 24- ALDH-Hi. In order get broader...
Abstract Ductal carcinoma in situ (DCIS) is considered an early stage of breast cancer and it the precursor invasive carcinoma. However, transition from normal epithelial cells to DCIS still not clearly elucidated. In order determine role lipogenesis transition, we investigated roles SREBP1, a major transcription regulator its downstream lipogenic genes such as ACLY, ACC1 FAS, by isolating stem-like (CSCs) DCIS.com cell line which forms typical lesions animals using well-established surface...
Abstract Most cancers are immunogenic, either due to neo-antigenic mutational load that makes them susceptible rejection by the adaptive immune system, or oncogenic stress pathways vulnerable innate anti-tumor responses. The therapeutic strategies reactivate host immunity have a great promise for cancer therapy. However, despite unprecedented of cure and durable disease management in select patients, response rates still low advanced cases, most which also relapse. These findings reflect...