A5067901389- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Amino Acid Enzymes and Metabolism
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Cancer Treatment and Pharmacology
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
- PI3K/AKT/mTOR signaling in cancer
- Receptor Mechanisms and Signaling
Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo
2013-2022
Ente Ospedaliero Ospedali Galliera
1996-2022
Creative Research Enterprises (United States)
2016
Cancer Genetics (United States)
2012-2016
Centre Antoine Lacassagne
2007-2016
University of Genoa
2015
AGH University of Krakow
2013
Southern Taiwan University of Science and Technology
2013
Wellcome Trust
2013
Medical Research Council
2013
Classical lissencephaly (smooth brain) or generalized agyriapachygyria is a severe brain malformation which results from an arrest of neuronal migration at 9–13 weeks gestation. It has been observed in several syndromes including Miller-Dieker syndrome (MDS) and isolated sequence (ILS). A gene containing β-transducin like repeats, now known as LIS1, was previously mapped to the ILS/MDS chromosome region on 17p13.3. We recently localized classical critical LIS1 locus by molecular analysis key...
Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces adaptive transcriptional upregulation of ASS1 and ASL in glioblastoma multiforme ex vivo cultures cell lines. This is blocked neoplasia-specific CpG island methylation gene, causing arginine auxotrophy death. In cells with methylated islands, ADI-PEG20 initially a protective autophagic response, but abrogation this chloroquine accelerates potentiates cytotoxicity. Concomitant the islands both ASL,...
Targeted therapies have yet to significant impact on the survival of patients with bladder cancer. In this study, we focused urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in cancer, based our discovery prognostic and functional import ASS1 setting. expression status tumors from 183 Caucasian 295 Asian was analyzed, along its hypothesized association clinicopathologic features, including tumor size invasion. Furthermore, genetics, biology, implications loss...
The cytokine TGF-β acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer can switch their response to use this potent oncogenic factor; however, mechanistic basis for is poorly understood. Here we demonstrate that downregulation disabled homolog 2 (DAB2) gene expression via promoter methylation frequently occurs human squamous cell carcinomas (SCCs) an independent predictor metastasis poor prognosis....
Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers. The mechanism(s) underlying deregulated expression the clinical consequences of changes not known. We used RT–PCR, qPCR, methylation-specific PCR pyrosequencing to analyse regulation NT5E melanoma cell lines primary metastatic melanomas. is subject epigenetic mRNA downregulated by...
Positive Platelia Aspergillus test results were observed in consecutive serum samples from an immunocompromised host during amoxicillin-clavulanic acid treatment, and a correlation between plasmatic amoxicillin concentration galactomannan optical density index was observed. Amoxicillin-clavulanic vials tested positive for but negative DNA.
Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis. ASS1 expression lost in a range of tumor types, including 50% malignant pleural mesotheliomas. Starving ASS1-deficient cells with blockers such as ADI-PEG20 can induce selective lethality and has shown great promise clinical setting. We have generated model resistance mesothelioma cells. This mediated through re-expression via demethylation promoter. Through coordinated transcriptomic metabolomic...
Background: NSCLC remains a challenging disease to treat, especially because the majority of patients present with advanced [1].For many these standard first-line therapy is platinumbased chemotherapy, which can prolong survival by 8-12 months in some and also improve disease-related symptoms [2].The chemotherapy treatments are frequently poorly tolerated.Treatment choices following limited, approved options include docetaxel, pemetrexed erlotinib.Recent developments immunotherapies approval...