A5057809323- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Hematopoietic Stem Cell Transplantation
- Prostate Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Prostate Cancer Treatment and Research
- Oral health in cancer treatment
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Surgical Treatments
- Breast Lesions and Carcinomas
- Radiation Therapy and Dosimetry
Ospedale Policlinico San Martino
2013-2022
University of Genoa
2013-2022
National Cancer Research Institute
2004-2021
Advanced Centre for Treatment, Research and Education in Cancer
2021
Tata Memorial Hospital
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2020
University of Florence
2018
Martin University
2017
Hôpital Beau-Séjour
2016
Candiolo Cancer Institute
2016
Purpose No randomized trials have been conducted to directly compare radiotherapy (RT) with concomitant cisplatin (CDDP) versus cetuximab (CTX) as first-line treatment of locally advanced squamous cell carcinoma the head and neck. In this trial, we compared these two regimens in terms compliance, toxicity, efficacy. Patients Methods Eligible patients were randomly assigned a 1:1 ratio receive either CDDP 40 mg/m 2 once per week or CTX 400 loading dose followed by 250 radical RT. For primary...
Because of the unprecedented disruption health care services caused by COVID-19 pandemic, American Society Radiation Oncology (ASTRO) and European for Radiotherapy (ESTRO) identified an urgent need to issue practice recommendations radiation oncologists treating head neck cancer (HNC) in a time limited resources heightened risk patients staff.
For patients with advanced, unresectable squamous-cell carcinoma of the head and neck, radiotherapy is standard treatment but has poor results. We therefore designed a randomized trial to determine whether alternating chemotherapy would improve survival such patients.
In 1992, we reported the first analysis of a randomized trial comparing alternating radiotherapy and chemotherapy with alone in treatment squamous cell carcinoma head neck. The results that 3-year indicated combined had superior efficacy.After an additional 2 years follow-up, again compared efficacy two regimens, attention paid to differences overall survival, progression-free locoregional relapse-free survival.One hundred fifty-seven patients untreated, unresectable neck were randomly...
Performing intensity-modulated radiotherapy (IMRT) on head and neck cancer patients (HNCPs) requires robust training experience. Thus, in 2011, the Head Neck Cancer Working Group (HNCWG) of Italian Association Radiation Oncology (AIRO) organized a study group with aim to run literature review outline clinical practice recommendations, suggest technical solutions advise target volumes doses selection for IMRT. The main purpose was therefore standardize approach radiation oncologists this...
Between 1983 and 1986, the National Institute for Cancer Research in Genoa affiliated institutions conducted a randomized study to compare two different ways of combining chemotherapy (CT) radiation therapy (RT). One hundred sixteen patients were receive neoadjuvant CT followed by definitive RT (treatment arm A) or alternating RT. In treatment A, consisted 70 Gy involved areas 50 uninvolved neck at 2 Gy/fraction, five fractions per week. B, 60 three courses 20 each, ten fractions/2 weeks...
We have previously shown that pharmacological inhibition of ataxia telangiectasia mutated (ATM) protein sensitizes glioblastoma-initiating cells (GICs) to ionizing radiation (IR). Herein, we report the experimental conditions overcome GIC radioresistance in vitro using specific ATM inhibitor KU-60019, two major determinants tumor response this drug and absence toxicity treatment vivo. Repeated treatments with KU-60019 followed by IR substantially delayed proliferation even eradicated...
We have recently reported that glioblastoma (GB)-initiating cells (GIC) with low expression and/or mutation of TP53 and high PI3K ("responder" genetic profile) can be effectively safely radiosensitized by the ATM inhibitor KU60019. report here on drug's diffusion elimination from animal body brain, its effects orthotopic GB efficacy toward pediatric GIC. Healthy mice were infused convection enhanced delivery (CED) KU60019 drug kinetics followed performance liquid chromatography-mass...
The COVID-19 pandemic has challenged healthcare systems worldwide over the last few months, and it continues to do so. Although some restrictions are being removed, is not certain when going be definitively over. Pandemics can seen as a highly complex logistic scenario. From this perspective, of indications provided for palliative radiotherapy (PRT) during could maintained in future settings that limit possibility patients achieving symptom relief by radiotherapy. This paper two aims: (1)...
To determine whether pretherapy cell kinetics can predict local control for patients affected by head and neck squamous carcinomas (HN-SCCs) to be treated primary radiotherapy and, moreover, guide a choice between conventional accelerated radiotherapy.Between 1989 1993, 83 with stage II IV HN-SCC entered the study. Multiple tumor biopsies were obtained 6 hours after in vivo infusion of bromodeoxyuridine (BrdUrd). In S-phase fraction labeling index (LI), duration S phase (Ts), potential...
Brachytherapy (BT, interventional radiotherapy - IRT) is a kind of radiation therapy, in which the radioactive source placed nearby or even inside cancer itself. Even though this therapy appears effective and valuable, BT has been facing slow but progressive decline over past decades Europe, particularly Italy. Aims study were to identify practical theoretical reasons why Italy, define vision Italian Association Radiotherapy Clinical Oncology (AIRO) strategy about emerged issues.A...