A5074670800- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Advanced Radiotherapy Techniques
- Fetal and Pediatric Neurological Disorders
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury Research
- Transcranial Magnetic Stimulation Studies
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Neonatal and fetal brain pathology
- Head and Neck Cancer Studies
- Management of metastatic bone disease
- Psychosomatic Disorders and Their Treatments
- Cerebrospinal fluid and hydrocephalus
- Cerebral Palsy and Movement Disorders
- Parkinson's Disease Mechanisms and Treatments
- Head and Neck Surgical Oncology
- Vestibular and auditory disorders
- Action Observation and Synchronization
- Olfactory and Sensory Function Studies
University of Messina
2016-2025
Tsinghua University
2023-2025
Morpho (United States)
2024
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2022
Centro Neurolesi Bonino Pulejo
2015-2019
Radiation Oncology Associates
2019
Digital Health Cooperative Research Centre
2019
Hamilton General Hospital
2019
McMaster University
2019
Digital China Health (China)
2019
Much of our present understanding the function and operation basal ganglia rests on models anatomical connectivity derived from tract-tracing approaches in rodents primates. However, last years have been characterized by promising step forwards vivo investigation comprehension brain humans. The aim this review is to revise current knowledge circuits, highlighting similarities differences across species, order widen perspective intricate model system. This will allow us explore implications...
The connections between the cerebellum and basal ganglia were assumed to occur at level of neocortex. However evidences from animal data have challenged this old perspective showing extensive subcortical pathways linking with ganglia. Here we tested hypothesis if these also exist in human brain by using diffusion magnetic resonance imaging tractography. Fifteen healthy subjects analyzed constrained spherical deconvolution technique obtained a 3T scanner. We found running subthalamic nucleus...
Translational network neuroscience aims to integrate advanced neuroimaging and data analysis techniques into clinical practice better understand treat neurological disorders. Despite the promise of technologies such as functional MRI diffusion combined with tools, field faces several challenges that hinder its swift translation. We have identified nine key roadblocks impede this process: (a) theoretical basic science foundations; (b) construction, interpretation, validation; (c) access,...
The current model of basal ganglia circuits has been introduced almost two decades ago and settled the basis for our understanding physiology movement disorders. Although many questions are yet to be answered, several efforts have recently made shed new light on function. traditional concept "direct" "indirect" pathways, obtained from axonal tracing studies in non-human primates post-mortem fiber dissection human brain, still retains a remarkable appeal but is somehow obsolete. Therefore,...
Purpose: To evaluate feasibility, toxicities, and clinical response in Stage IV patients treated with palliative “metabolism-guided” lattice technique. Patients Methods: From June 2020 to December 2021, 30 consecutive stage 31 bulky lesions were included this study. All received irradiation consisting of a spatially fractionated high radiation dose delivered spherical deposits (vertices, Vs) within the disease. The Vs placed at edges tumor areas different metabolisms PET exam following...
Understanding the topographical organization of cortico-basal ganglia circuitry is pivotal importance because spreading techniques such as DBS and, more recently, MR-guided focused ultrasound for treatment movement disorders. A growing body evidence has described both direct cortico- and dento-pallidal connections, although in vivo these pathways human brain never been reported.To investigate by means diffusion MRI tractography connectivity based parcellation.High-quality data from 100...
Consciousness arises from the functional interaction of multiple brain structures and their ability to integrate different complex patterns internal communication. Although several studies demonstrated that fronto-parietal default mode networks play a key role in conscious processes, it is still not clear which topological network measures (that quantifies features whole-brain organization) are altered patients with disorders consciousness. Herein, we investigate connectivity unresponsive...
The COVID-19 pandemic has challenged healthcare systems worldwide over the last few months, and it continues to do so. Although some restrictions are being removed, is not certain when going be definitively over. Pandemics can seen as a highly complex logistic scenario. From this perspective, of indications provided for palliative radiotherapy (PRT) during could maintained in future settings that limit possibility patients achieving symptom relief by radiotherapy. This paper two aims: (1)...
Purpose: To determine the best predictor of lesion volume induced by magnetic resonance (MR)-guided focused ultrasound (MRgFUS) thalamotomy in patients with tremor-dominant symptoms Parkinson’s disease (PD) and essential tremor (ET) patients. Methods: Thirty-six neurological medication-refractory (n°19 PD; n°17 ET) were treated using a commercial MRgFUS brain system (Exablate Neuro 4000, Insightec) integrated 1.5 T MRI unit (Sigma HDxt; GE Medical System). Linear regression analysis was used...
Frontotemporal dementia involves progressive atrophy in deep gray matter nuclei, including the thalamus and basal ganglia (such as caudate, putamen, nucleus accumbens, globus pallidus), which are critical for cognition behavior. This study examined cross-sectional longitudinal using a state-of-the-art multi-atlas segmentation method sTHOMAS. T1-weighted MRI scans from 274 participants at baseline 237 follow-up obtained Lobar Degeneration Neuroimaging Initiative database were analyzed Group...
Machine learning may enhance clinical data analysis but requires large amounts of training data, which are scarce for rare pathologies. While generative neural network models can create realistic synthetic such as 3D MRI volumes and, thus, augment datasets, the generation complex remains challenging. Fibre orientation distributions (FODs) represent one type, modelling diffusion spherical harmonics with stored weights multiple three-dimensional volumes. We successfully trained an α-WGAN...
In the last decades, a number of Diffusion Weighted Imaging (DWI) based techniques have been developed to study non-invasively human brain tissues, especially white matter (WM). this context, Constrained Spherical Deconvolution (CSD) is recognized as being able accurately characterize water molecules displacement, they emerge from observation MR diffusion weighted (MR-DW) images. CSD suggested be applied on MR-DW datasets consisting b-values around 3,000 s/mm2 and at least 45 unique...