A5089337707- Dementia and Cognitive Impairment Research
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Down syndrome and intellectual disability research
- Neuroscience and Neural Engineering
- Frailty in Older Adults
- Health, Environment, Cognitive Aging
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Cerebrovascular and Carotid Artery Diseases
- Retinal Imaging and Analysis
- Music Therapy and Health
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
Massachusetts Institute of Technology
2021-2023
Columbia University
2019-2021
Institute of Cognitive and Brain Sciences
2021
Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral atrophy, improves behavioral testing performance in mouse models of AD. Here, we report data from (1) a Phase 1 feasibility study (NCT04042922, ClinicalTrials.gov) cognitively normal volunteers (n = 25), patients with mild AD dementia 16), epilepsy who underwent intracranial electrode monitoring 2) to assess safety single brief...
Adults with Down syndrome (DS) develop Alzheimer disease (AD) pathology by their 5th decade. Compared the general population, traditional vascular risks in adults DS are rare, allowing examination of cerebrovascular this population and insight into its role AD without confound risk factors. We examined vivo magnetic resonance imaging (MRI)-based biomarkers DS, determined cross-sectional relationship age, beta-amyloid pathology, mild cognitive impairment or clinical diagnostic status.
The risk for neurodegenerative diseases increases with aging, various pathological conditions and functional deficits accompanying these diseases. We have previously demonstrated that non-invasive visual stimulation using 40 Hz light flicker ameliorated pathology modified cognitive function in mouse models of neurodegeneration, but whether another sensory modality can impact neurodegeneration motor has not been studied. Here, we show whole-body vibrotactile at leads to increased neural...
Frontotemporal dementia involves progressive atrophy in deep gray matter nuclei, including the thalamus and basal ganglia (such as caudate, putamen, nucleus accumbens, globus pallidus), which are critical for cognition behavior. This study examined cross-sectional longitudinal using a state-of-the-art multi-atlas segmentation method sTHOMAS. T1-weighted MRI scans from 274 participants at baseline 237 follow-up obtained Lobar Degeneration Neuroimaging Initiative database were analyzed Group...
SUMMARY Non-invasive G amma EN trainment U sing S ensory stimuli (GENUS) at 40Hz reduced Alzheimer’s disease (AD) pathology, prevented cerebral atrophy and improved performance during behavioral testing in mouse models of AD. We report data from a safety study ( NCT04042922 ) randomized, placebo-controlled trial participants with probable mild AD dementia after 3 months one-hour daily light sound GENUS NCT04055376 to assess safety, compliance, entrainment possible effects on brain structure,...
Abstract Background Non‐invasive gamma frequency light and sound stimulation at 40Hz reduced Alzheimer’s disease (AD) pathology improved performance during behavioral testing in mouse models of AD (Iaccarino et al., Nature , 2016; Martorell Cell 2019; Adaikkan Neuron 2019). Sensory inducing entrainment amyloid hyperphosphorylated tau burden prevented brain atrophy different AD. Performance on tasks short‐term memory spatial learning after 6 weeks daily stimulation. We therefore hypothesized...
Non-invasive Gamma ENtrainment Using Sensory stimuli (GENUS) at 40Hz reduced Alzheimer's disease (AD) pathology, prevented cerebral atrophy and improved performance during behavioral testing in mouse models of AD. We report data from a safety study (NCT04042922) randomized, placebo-controlled trial participants with probable mild AD dementia after 3 months one-hour daily light sound GENUS (NCT04055376) to assess safety, compliance, entrainment possible effects on brain structure, function,...
There is a general consensus that cerebrovascular change plays role in the clinical presentation of Alzheimer's disease(AD) but considerable debate about its disease pathogenesis. Adults with Down syndrome(DS), like those autosomal dominant mutations for AD, develop AD pathology and symptoms by their 40s 60s, respectively. Unlike population, individuals DS have low prevalence classical vascular risk factors, such as hypertension, which provides opportunity to study without confound systemic...
Down syndrome (DS) is the most common genetic cause of neurodevelopmental delay believed due to defects in neurogenesis, neuronal differentiation, and impaired synaptic plasticity learning. Virtually all adults with DS develop Alzheimer Disease (AD) -associated neuropathology by age 40 dementia 60. Hippocampal atrophy associated presence Alzheimer's disease memory loss. We determined whether hippocampal clinical status DS. 71 Adults enrolled Biomarkers Syndrome (ADDS) study consortium...
The ADDS study, part of the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS)[1], aims to identify biomarkers associated with AD in older adults DS. Here we report on baseline brain amyloid (18F-AV-45) by consensus diagnosis 66 participants who completed PET scans. Participants were given a of: cognitively stable(CS; n=41; age=50+/-6), mild cognitive impairment(MCI; n=15; age=54+/-7), or possible/probable dementia(DEM; n=10; age=56+/-7) using consensus-based procedure[2] (Table 1)....
The ADDS study, part of the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS)[1], aims to identify biomarkers associated with AD in older adults DS. Here we report on baseline brain amyloid (18F-AV-45) by consensus diagnosis 66 participants who completed PET scans. Participants were given a of: cognitively stable(CS; n=41; age=50+/-6), mild cognitive impairment(MCI; n=15; age=54+/-7), or possible/probable dementia(DEM; n=10; age=56+/-7) using consensus-based procedure[2] (Table 1)....