Christy Hom
A5026870189- Down syndrome and intellectual disability research
- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Chronic Disease Management Strategies
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Adventure Sports and Sensation Seeking
- ECG Monitoring and Analysis
- Sleep and related disorders
- Health, Environment, Cognitive Aging
- Traumatic Brain Injury Research
- Outdoor and Experiential Education
- Bipolar Disorder and Treatment
- Adolescent and Pediatric Healthcare
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Health and Disease Prevention
- Infant Development and Preterm Care
- Medical Imaging Techniques and Applications
- Language Development and Disorders
- Educational and Psychological Assessments
- Retinal Imaging and Analysis
- Neurology and Historical Studies
- Medication Adherence and Compliance
- Aging, Health, and Disability
University of California, Irvine
2014-2025
University of Washington
2024
University of North Carolina at Chapel Hill
2022
Lady Hardinge Medical College
2022
Czech Academy of Sciences, Institute of Experimental Medicine
2022
New York State Office for People With Developmental Disabilities
2020
Abstract INTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins decade or more prior onset clinical dementia in people DS. It is not clear if plasma biomarkers are correlated early cognitive and functional impairments DS, these could be used track the stages DS inform inclusion criteria for treatment trials. METHODS This large cross‐sectional cohort study investigated associations between amyloid beta (Aβ)42/40, total tau,...
Abstract By age 40 years, over 90% of adults with Down syndrome have Alzheimer’s disease pathology and most progress to dementia. Despite having few systemic vascular risk factors, individuals elevated cerebrovascular markers that track the clinical progression disease, suggesting a role is hypothesized be mediated by inflammatory factors. This study examined pathways through which small vessel contributes disease-related pathophysiology neurodegeneration in syndrome. One hundred eighty-five...
Abstract INTRODUCTION Aging adults with Down syndrome (DS) accumulate Alzheimer's disease (AD) neuropathology, including amyloid beta plaques and neurofibrillary tangles, by age 40. METHODS We present findings from an individual DS who remained cognitively stable despite AD neuropathology. Clinical assessments, fluid biomarkers, neuroimaging, neuropathological examinations were conducted to characterize her condition. RESULTS Her apolipoprotein E was ε2/ε3 genome‐wide association study data...
Abstract Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), is common in elderly brains and often seen conjunction with Alzheimer’s disease (ADNC). LATE-NC typically begins the amygdala spreads to hippocampus neocortex. Whether it contributes hippocampal atrophy Down syndrome (DS) remains unexplored. We analyzed volumes neuropathological burden 12 DS cases 54 non-DS AD related neurodegenerative pathologies (ADRNP) using 7 Tesla (7T) postmortem ex vivo MRI....
Abstract Background Adults with Down syndrome (DS) have a 90% lifetime risk for Alzheimer’s disease (AD), neurobiological pathology present decades prior to dementia onset. The profile and timing of cognitive decline in DS is well-documented. However, there small body research on whether Behavioral Psychological Symptoms Dementia (BPSD) occur early the progression AD are associated (i.e., amyloid-beta [Aβ] neurofibrillary tau tangles [NFT]). Methods Data were analyzed from 337 adults ( M =...
ABSTRACT Background Adults with Down syndrome (DS) have an elevated risk and early age of onset for Alzheimer's disease ( AD ). To support upcoming clinical trials, there is a critical need to establish cognitive outcome measures that can be used capture intervention effects. One measure has successfully been detect ‐related decline in the DS population episodic memory, modified Cued Recall Test (mCRT). Demonstrated utility mCRT warrants further investigation into comparisons between A B...
The Down syndrome population has been disproportionately affected by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal efforts to curb the spread COVID-19 may also have taken a heavy toll on daily lives individuals with syndrome.The goal study was understand how pandemic altered life (including residence, employment, participation adult disability day programs) influenced mood behavior adults syndrome.Between September 2020 February 2021, caregivers 171...
Virtually all people with Down syndrome (DS) develop neuropathology associated Alzheimer's disease (AD). Atrophy of the hippocampus and entorhinal cortex (EC), as well elevated plasma concentrations neurofilament light chain (NfL) protein, are markers neurodegeneration late-onset AD. We hypothesized that EC gray matter loss increased NfL memory in adults DS.
The accuracy of the National Task Group-Early Detection Screen for Dementia (NTG-EDSD) was evaluated in a sample 185 adults with Down syndrome (DS), emphasizing 'mild cognitive impairment (MCI-DS)'.Knowledgeable informants were interviewed NTG-EDSD, and findings compared to an independent dementia status rating based on consensus review detailed assessments cognition, functional abilities health (including physician examination).Results indicated that sections NTG-EDSD sensitive MCI-DS, one...
Introduction Adults with Down syndrome (DS) are at high risk for early onset Alzheimer's disease (AD), characterized by a progressive decline in multiple cognitive domains including language, which can impact social interactions, behavior, and quality of life. This cross-sectional study examined the relationship between language skills dementia. Methods A total 168 adults DS (mean age = 51.4 years) received neuropsychological assessments, Vineland Communication Domain, McCarthy Verbal...
Abstract Introduction The development of valid methods to diagnose prodromal Alzheimer's disease (AD) in adults with Down syndrome (DS) is one the many goals Biomarkers Consortium—Down Syndrome (ABC‐DS). Methods diagnostic utility a modified Cued Recall Test (mCRT) was evaluated 332 DS ranging from 25 81 years age. Total recall selected priori, as primary indicator performance. Multiple regression and receiver‐operating characteristic (ROC) analyses were used compare groups. Results...
Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment DS (MCI-DS) and test these hypotheses using cross-sectional longitudinal data. 18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze burden 58 participants clinically classified as cognitively stable (CS) or MCI-DS 12 CS participants. The study confirmed our increased inferior parietal,...
Abstract INTRODUCTION This study aimed to investigate the influence of overall Alzheimer's disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and cerebrospinal fluid (CSF) biomarkers. METHODS AD polygenic risk scores (PRS) were tested for association with DS‐related traits. RESULTS The PRS was associated status in several cohorts sporadic late‐ early‐onset familial late‐onset AD, but not or DS. On other hand, lower DS Mental Status Examination memory higher...
Abstract Background Non‐adherence to antiepileptic drugs ( AEDs ) is associated with considerable morbidity and mortality in the general population but little known about adherence individuals intellectual disability ID ). Method Using records of a closed pharmacy billing system over 30 month period, we examined medication non‐adherence rates for among 793 . We calculated possession ratio (number days each participant was an AED ), defined as 25% or more exposure without All participants...
Self-concept is a critical indicator of quality life but few studies have examined this subject in children with Down syndrome (DS). In study, we propose novel methodology to assess the self-concept DS by analyzing their responses towards two dolls, one "typically developing" (TD) appearance and phenotypic features DS. Fifty-four participated play sessions both dolls were then interviewed doll preference, resemblance, attribution positive qualities. We observed that DS: (i) exhibited...
Abstract In this neuropathology case report, we present findings from an individual with Down syndrome (DS) who remained cognitively stable despite Alzheimer’s disease (AD) neuropathology. Clinical assessments, fluid biomarkers, neuroimaging, and neuropathological examinations were conducted to characterize her condition. Notably, ApoE genotype was E2/3, which is associated a decreased risk of dementia. Neuroimaging revealed yet elevated amyloid profiles moderately tau levels, while...
Abstract Background Individuals with developmental disabilities (DD) often have severe impairments and maladaptive behaviours that make it difficult to reliably assess their cognitive abilities. Given these challenges, the Rapid Assessment of Developmental Disabilities, Second Edition (RADD‐2), was designed measure general ability in this population. The purpose study is demonstrate battery's psychometric properties when used individuals DD who challenging behavioural psychiatric conditions...
Background: Trisomy 21 causes Down syndrome (DS) and is a recognized cause of early-onset Alzheimer’s disease (AD). Objective: The current study sought to determine if premorbid intellectual disability level (ID) was associated with variability in age-trajectories AD biomarkers cognitive impairments. General linear mixed models compared the age-trajectory PET Aβ tau decline across ID levels (mild, moderate, severe/profound), controlling trisomy type, APOE status, biological sex, site....
Accurate identification of the prodromal stage Alzheimer's disease (AD), known as mild cognitive impairment (MCI), in adults with Down syndrome (MCI-DS) has been challenging because there are no established diagnostic criteria that can be applied for people lifelong intellectual disabilities (ID). As such, sequence decline DS difficult to ascertain, and it is possible domain constructs characterizing function neurotypical do not generalize this high-risk population. The present study...
Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification regression tree (CART) analyses to identify an abbreviated battery for classification. Scale- subscale-level scores from 141 participants (no n = 68; probable Alzheimer's disease 73), the Severe Impairment Battery (SIB), Dementia Scale People with Learning Disabilities (DLD), Vineland Adaptive Behavior Scales-Second...