A5014819568- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Down syndrome and intellectual disability research
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Chronic Disease Management Strategies
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Cancer-related cognitive impairment studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Pharmaceutical Practices and Patient Outcomes
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Health, Environment, Cognitive Aging
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Obstructive Sleep Apnea Research
- Traumatic Brain Injury Research
- Memory Processes and Influences
University of Kentucky
2016-2025
Center for Autism and Related Disorders
2022
University of North Carolina at Chapel Hill
2022
University of Leeds
2022
Alzheimer's Association
2022
University of California, Irvine
2021
Neurology, Inc
2008-2020
Université de Lille
2019
Centre Hospitalier Universitaire de Lille
2019
Université d'Angers
2019
Overstimulation of the N-methyl-D-aspartate (NMDA) receptor by glutamate is implicated in neurodegenerative disorders. Accordingly, we investigated memantine, an NMDA antagonist, for treatment Alzheimer's disease.
To evaluate the total number of synapses in stratum radiatum (str rad) human hippocampal CA1 subfield individuals with mild Alzheimer disease (mAD), cognitive impairment (MCI), or no (NCI) and determine if synapse loss is an early event progression disease.Short postmortem autopsy tissue was obtained, unbiased stereologic sampling scheme coupled transmission electron microscopy used to directly visualize synaptic contacts.Individuals mAD had fewer (55%) than other two diagnostic groups....
This article reports the development and psychometric properties of Alzheimer's Disease Cooperative Study-Clinical Global Impression Change (ADCS-CGIC). At present, a number unvalidated CGIC scales are used in clinical trials, with various methods for making ratings. The ADCS-CGIC was designed on basis survey ADCS clinicians by adapting existing instruments. It includes an organized but unstructured format, which clinician can address clinically relevant change. instrument's reliability...
<b>Objective: </b> To determine if increased levels of oxidative damage are present in the brains persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). <b>Methods: The authors assessed amount protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde superior middle temporal gyri (SMTG) cerebellum short postmortem interval longitudinally evaluated normal subjects those MCI early AD. <b>Results: Elevated carbonyls...
The histopathologic changes distinguishing early Alzheimer disease (AD) from normal or pathologic aging arc not clearly defined. This report describes the autopsy findings of 59 elderly, well-educated, volunteers. They were examined longitudinally with mental status testing, some for up to 8 years, as part our study. study reveals that (1) brains many subjects who did show cognitive impairment on neuropsychologic testing contain abundant senile plaques (SP) and/or neurofibrillary tangles...
<h3>Objective</h3> To define the neuropathologic findings in amnestic mild cognitive impairment (MCI) and early Alzheimer disease (EAD). <h3>Methods</h3> The mean numbers of diffuse plaques, neuritic plaques (NPs), neurofibrillary tangles (NFTs) 4 neocortical regions ventromedial temporal lobe were counted 10 patients with MCI compared 23 normal control subjects EAD, then memory performance. All controls followed longitudinally. <h3>Results</h3> Patients showed no significant difference...
Alzheimer's disease (AD) is a slowly progressing form of dementia characterized in its earliest stages as loss memory. Individuals with amnestic mild cognitive impairment (aMCI) may be the and represent an opportunity to identify pathological changes related progression AD. Synaptic one hallmarks AD associated impairment. The inferior temporal gyrus plays important role verbal fluency, function affected early onset Unbiased stereology coupled electron microscopy was used quantify total...
Oxidative stress is an established dementia pathway, but it unknown if the use of antioxidant supplements can prevent dementia.To determine (vitamin E or selenium) used alone in combination asymptomatic older men.The Prevention Alzheimer's Disease by Vitamin and Selenium (PREADViSE) trial began as a double-blind randomized clinical May 2002, which transformed into cohort study from September 2009 to 2015. The PREADViSE was ancillary Cancer Trial (SELECT), same for preventing prostate cancer,...
Hippocampal sclerosis is a relatively common neuropathological finding (∼10% of individuals over the age 85 years) characterized by cell loss and gliosis in hippocampus that not explained Alzheimer's disease. pathology can be associated with different underlying causes, we refer to hippocampal aged brain as ageing. Much remains unknown about We combined three large autopsy cohorts: University Kentucky Disease Centre, Nun Study Georgia Centenarian obtain pool 1110 patients, all whom were...
Neuropathological, genetic, and biochemical studies have provided support for the hypothesis that microglia participate in Alzheimer's disease (AD) pathogenesis. Despite extensive characterization of AD microglia, there are still many unanswered questions, little is known about microglial morphology other common forms age-related dementia: particularly, dementia with Lewy bodies (DLB) hippocampal sclerosis aging (HS-Aging). In addition, no prior attempted to compare contrast hippocampus...
The relationship of diabetes to specific neuropathologic causes dementia is incompletely understood.We used logistic regression evaluate the association between and infarcts, Braak neurofibrillary tangle stage, neuritic plaque score in 2365 autopsied persons. In a subset >1300 persons with available cognitive data, we examined cognition using Poisson regression.Diabetes increased odds brain infarcts (odds ratio [OR] = 1.57, P < .0001), specifically lacunes (OR 1.71, but not Alzheimer's...
<h3>Importance</h3> Quadruple misfolded proteins (tau neurofibrillary tangles, amyloid-β [Aβ], α-synuclein, and transactive response DNA-binding protein 43 [TDP-43]) in the same brain are relatively common aging. However, clinical presentation, associated factors, frequency community-based cohorts, genetic characteristics, cognitive trajectories with quadruple phenotype not well understood. <h3>Objective</h3> To describe phenotype, including of global cognition, an autopsy cohort....
<b><i>Objective:</i></b> To classify neuropathologic alterations in the brains of nondemented older adults using current sets criteria for AD. <b><i>Background:</i></b> AD are found some elderly subjects and suggest possibility presymptomatic Three guidelines have been developed to senile plaques, neuritic neurofibrillary tangles (NFT). <b><i>Methods:</i></b> Neuropathologic changes 59 followed longitudinally with a standard battery mental status measures were investigated Khachaturian,...
There is uncertainty regarding the association of cognitive decline in Alzheimer disease (AD) with classic histopathologic features- neurofibrillary tangles (NFTs) and "neuritic" amyloid plaques (NPs). This fuels doubts about diagnostic importance NFTs NPs leads to confusion hypotheses AD pathogenesis. Three hundred ninety subjects who underwent longitudinal premortem clinical workup postmortem quantitative neuropathologic assessment served as group address this issue. Subjects concomitant...
<b><i>Background:</i></b> Slowing of motor movements in human aging is a well-known occurrence, but its biologic basis poorly understood. Reliable quantitation may refine observations this phenomenon to better aid research on entity. <b><i>Methods:</i></b> A panel equipped with timing sensors under computer control was used measure upper extremity movement times two groups healthy individuals: adults younger than 60 years age (n = 56; range, 18–58 years) and older 38; 61–94 years)....
Abstract Neurochemical assessments were performed on biopsy samples taken from the right frontal lobe of patients diagnosed with Alzheimer's disease (AD), before implantation a ventricular catheter and pump assembly for infusion bethanechol chloride as an experimental therapy. The pathologically AD (n = 35; mean age, 67 ± 1.5 yr) compared group normal age‐equivalent autopsied controls 22; 68 2 brains 11; 73 yr). Samples assayed choline acetyltransferase (ChAT), acetylcholinesterase, binding...
We evaluated the association between mini-mental status examination (MMSE) scores proximal to death and values of 43 different clinical pathological parameters. Studies were performed using data from 334 elderly, longitudinally research subjects who had undergone autopsy satisfied inclusion criteria an initial study group 501. Interindividual variance in MMSE was used as a surrogate for severity cognitive impairment linked aging (CILA). A statistical linear regression-based model provided...