A5101937767- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Health disparities and outcomes
- Sleep and Wakefulness Research
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Sleep and related disorders
- Aging and Gerontology Research
- Advanced Neuroimaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Financial Literacy, Pension, Retirement Analysis
- Elder Abuse and Neglect
- Frailty in Older Adults
- Health Literacy and Information Accessibility
- Technology Use by Older Adults
- Genetic Associations and Epidemiology
- Circadian rhythm and melatonin
- Decision-Making and Behavioral Economics
- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Retirement, Disability, and Employment
Rush University Medical Center
2016-2025
Suizhou Central Hospital
2025
Shaanxi Normal University
2025
Rush University
2015-2024
Columbia University Irving Medical Center
2018-2024
Harvard University
2015-2024
Tea Research Institute
2024
Western University
2018-2024
The Memory Clinic
2024
Lund University
2024
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by stereotypical proteinopathy in older adults, with or without coexisting hippocampal sclerosis pathology. LATE-NC common proteinopathy, associated an amnestic dementia syndrome that mimicked Alzheimer's-type retrospective autopsy studies. distinguished from frontotemporal lobar degeneration pathology based on its epidemiology...
Cross-sectional studies suggest that sleep fragmentation is associated with cognitive performance in older adults. We tested the hypothesis incident Alzheimer's disease (AD) and rate of decline adults.Prospective cohort study.Community-based.737 community dwelling adults without dementia.Sleep was quantified from up to 10 consecutive days actigraphy. Subjects underwent annual evaluation for AD 19 neuropsychological tests. Over a follow-up period 6 years (mean 3.3 years), 97 individuals...
Abstract We initiated the systematic profiling of dorsolateral prefrontal cortex obtained from a subset autopsied individuals enrolled in Religious Orders Study (ROS) or Rush Memory and Aging Project (MAP), which are jointly designed prospective studies aging dementia with detailed, longitudinal cognitive phenotyping during life quantitative, structured neuropathologic examination after death. They include over 3,322 subjects. Here, we outline first generation data including genome-wide...
Abstract A highly crystalline copper(II) benzenehexathiolate coordination polymer (Cu‐BHT) has been prepared. The two‐dimensional kagome structure confirmed by powder X‐ray diffraction, high‐resolution transmission electron microscopy, and scanning microscopy. as‐prepared sample exhibits bulk superconductivity at about 0.25 K, which is the zero resistivity, AC magnetic susceptibility, specific heat measurements. Another diamagnetic transition 3 K suggests that there a second superconducting...
<h3>Objective:</h3> To test the hypothesis that cognitive activity across life span is related to late-life decline not linked common neuropathologic disorders. <h3>Methods:</h3> On enrollment, older participants in a longitudinal clinical-pathologic cohort study rated (i.e., current) and early-life participation cognitively stimulating activities. After mean of 5.8 years annual function testing, 294 individuals had died undergone examination. Chronic gross infarcts, chronic microscopic...
Lewy bodies are common in the ageing brain and often co-occur with Alzheimer's disease pathology. There is little known regarding independent role of body pathology cognition impairment, decline fluctuations community-dwelling older persons. We examined contribution to dementia, global cognition, cognitive domains, 872 autopsied subjects (mean age = 87.9 years) from Rush Religious Order Study (n 491) Memory Aging Project 381) longitudinal community-based clinical–pathological studies....
The apolipoprotein E (APOE [GenBank, 348; OMIM, 107741]) ε4 allele is a common and well-established genetic risk factor for Alzheimer disease (AD). Sleep consolidation also associated with AD risk, previous work suggests that APOE genotype sleep may interact to influence cognitive function.To determine whether better attenuates the relationship of incident burden pathology.A prospective longitudinal cohort study up 6 years follow-up was conducted. Participants included 698 community-dwelling...
Objective The degree to which Alzheimer's versus other neuropathologies contribute the risk of dementia is unknown. We examined attributable pathologic AD and 8 neuropathologies. Methods Participants (n = 1,161) came from 2 clinical‐pathological studies aging. Multivariable logistic regression models associations neuropathological indices with quantified percentage cases each. Furthermore, because some are not driven by common neuropathologies, we re‐estimated risks after empirically...
Cognitive decline is a leading cause of disability and death in old age but its neurobiological bases are not well understood.
The relationship of diabetes to specific neuropathologic causes dementia is incompletely understood.We used logistic regression evaluate the association between and infarcts, Braak neurofibrillary tangle stage, neuritic plaque score in 2365 autopsied persons. In a subset >1300 persons with available cognitive data, we examined cognition using Poisson regression.Diabetes increased odds brain infarcts (odds ratio [OR] = 1.57, P < .0001), specifically lacunes (OR 1.71, but not Alzheimer's...
<h3>Objectives:</h3> We tested whether brain-derived neurotrophic factor (<i>BDNF</i>) gene expression levels are associated with cognitive decline in older adults. <h3>Methods:</h3> Five hundred thirty-five participants underwent annual assessments and brain autopsy at death. <i>BDNF</i> was measured the dorsolateral prefrontal cortex. Linear mixed models were used to examine adjusting for age, sex, education. An interaction term added determine this association varied clinical diagnosis...
Objective Our objectives were to characterize the inter‐relation of known dementia‐related neuropathologies in one comprehensive model and quantify extent which accumulation accounts for association between age dementia. Methods We used data from 1,362 autopsied participants three community‐based clinicopathological cohorts: Religious Orders Study, Rush Memory Aging Project, Minority Research Study. estimated a series structural equation models summarizing priori hypothesized...
The ageing brain is vulnerable to a wide array of neuropathologies. Prior work estimated that the three most studied these, Alzheimer's disease, infarcts, and Lewy bodies, account for ∼40% variation in late life cognitive decline. However, estimate did not incorporate many other diseases are now recognized as potent drivers decline [e.g. limbic predominant age-related TDP-43 encephalopathy (LATE-NC), hippocampal sclerosis, cerebrovascular conditions]. We examined degree which person-specific...
Daytime napping is frequently seen in older adults. The longitudinal relationship between daytime and cognitive aging unknown.
Physical exercise is known to reduce anxiety, but the underlying brain mechanisms remain unclear. Here, we explore a hypothalamo-cerebello-amygdalar circuit that may mediate motor-dependent alleviation of anxiety. This three-neuron loop, in which cerebellar dentate nucleus takes center stage, bridges motor system with emotional system. Subjecting animals constant rotarod engages glutamatergic neurons drive PKCδ+ amygdalar elicit an anxiolytic effect. Moreover, challenging on accelerated...
Objective Decision making is an important determinant of health and well-being across the lifespan but critical in aging, when many influential decisions are made just as cognitive function declines. Increasing evidence suggests that older adults, even those without dementia, often make poor selectively vulnerable to scams. To date, however, factors associated with decision old age unknown. The objective this study was test hypothesis a consequence decline among persons Alzheimer's disease...
This study addressed the hypothesis that late life cognitive decline leads to loss of well-being. Participants are older persons from Rush Memory and Aging Project. Beginning in 2001, they underwent annual clinical evaluations included detailed performance testing a 10-item self-report measure purpose life, an aspect Initial analyses involved 1,049 individuals who were without dementia at baseline followed mean 5.0 years. The intercepts slopes global cognition positively correlated, level...
Objective.First, we tested the hypothesis that rate of change physical frailty and cognitive function in older adults are correlated. Next, examined if their rates associated with same brain pathologies.
Existing evidence suggests that psychosocial stress is associated with cognitive impairment in older adults. Perceived discrimination a persistent stressor African Americans has been several adverse mental and physical health outcomes. To our knowledge, the association of cognition not examined. In cohort 407 without dementia (mean age = 72.9; SD 6.4), we found higher level perceived was related to poorer test performance, particularly episodic memory (estimate -0.03; SE .013; p < .05)...
Fragmented sleep is a common and troubling symptom in ageing Alzheimer's disease; however, its neurobiological basis many patients unknown. In rodents, lesions of the hypothalamic ventrolateral preoptic nucleus cause fragmented sleep. We previously proposed that intermediate human hypothalamus, which has similar location neurotransmitter profile, homologue nucleus, but physiological data humans were lacking. hypothesized if important for sleep, then cell loss may contribute to fragmentation...
<h3>Objective:</h3> To characterize the natural history and neuropathologic basis of unawareness memory loss in late-life dementia. <h3>Methods:</h3> Analyses are based on 2,092 older persons from 3 longitudinal clinical-pathologic cohort studies who had no or cognitive impairment at baseline. Annual evaluations included clinical classification dementia plus self-rating performance testing memory. At death, there was a uniform examination to quantify 7 dementia-related pathologies....
TDP-43 pathology was investigated in the anterior temporal pole cortex (ATPC) and orbital frontal (OFC), regions often degenerated frontotemporal lobar degenerations (FTLD), aging Alzheimer's disease (AD). Diagnosis of dementia 1160 autopsied participants from 3 studies community-dwelling elders based on clinical evaluation cognitive performance tests which were used to create summary measures five domains. Neuronal glial cytoplasmic inclusions quantitated 8 brain by immunohistochemistry,...