A5026996448- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Aging and Gerontology Research
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Racial and Ethnic Identity Research
- Advanced Neuroimaging Techniques and Applications
- Frailty in Older Adults
- Neuroinflammation and Neurodegeneration Mechanisms
- Geriatric Care and Nursing Homes
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Migration, Aging, and Tourism Studies
- Neurological Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
- Retirement, Disability, and Employment
- Blood Pressure and Hypertension Studies
- Urban Transport and Accessibility
- Nutrition and Health in Aging
- Balance, Gait, and Falls Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Cognitive Abilities and Testing
Rush University Medical Center
2016-2025
University of California, Davis
2025
Rush University
2015-2024
University of Illinois Chicago
2012-2024
Alzheimer’s Disease Neuroimaging Initiative
2022-2024
Harvard University
2013-2024
Western University of Health Sciences
2024
Children's Hospital of Western Ontario
2024
Western University
2024
Australian National University
2024
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified genetic sharing 25 disorders from genome-wide association studies 265,218 patients 784,643 control participants assessed relationship to 17 phenotypes 1,191,588 individuals. Psychiatric common variant risk, whereas neurological appear more distinct one another psychiatric disorders. also identified significant between a number...
Social isolation in old age has been associated with risk of developing dementia, but the perceived isolation, or loneliness, is not well understood.To test hypothesis that loneliness increased Alzheimer disease (AD).Longitudinal clinicopathologic cohort study up to 4 years annual in-home follow-up.A total 823 older persons free dementia at enrollment were recruited from senior citizen facilities and around Chicago, Ill. Loneliness was assessed a 5-item scale baseline (mean +/- SD, 2.3 0.6)...
<b><i><i>Background:</i></i></b> Cognitive abilities of older persons range from normal, to mild cognitive impairment, dementia. Few large longitudinal studies have compared the natural history impairment with similar without impairment. <b><i><i>Methods:</i></i></b> Participants were Catholic clergy dementia, 211 and 587 who underwent annual clinical evaluation for AD an assessment different abilities. performance tests summarized yield a composite measure global function separate summary...
A reliability generalization study for Spielberger’s State-Trait Anxiety Inventory (STAI) was conducted. total of 816 research articles utilizing the STAI between 1990 and 2000 were reviewed classified as having (a) ignored (73%), (b) mentioned or reported coefficients from another source (21%), (c) computed data at hand (6%). Articles in medically oriented journals shorter somewhat less likely to mention compute than nonmedically articles, perhaps due paradigm differences. Average...
The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific the nutrition literature on dementia prevention.
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions aging with an emphasis on decline in cognitive motor function risk Alzheimer’s disease (AD). In this manuscript, we first summarize the design methods. Then, present data on: 1) relation to cognition, disability, death; 2) factors outcomes, disability 3) neuropathologic indices outcomes; 4) indices; 5) additional findings. findings are discussed contextualized....
The authors examined change in cognitive abilities older Catholic clergy members. For up to 6 years, participants underwent annual clinical evaluations, which included a battery of tests from summary measures 7 were derived. On average, decline occurred each ability and was more rapid persons than younger persons. However, wide individual differences evident at all ages. Rate given domain not strongly related baseline level function that but moderately associated with rates other domains....
Abstract Introduction The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding the burden. Methods We estimated using a quasibinomial regression model in 10,342 participants test scores. Results 2020 US Census–adjusted prevalence AD was 11.3% (95% confidence interval [CI] = 10.7–11.9): 10.0% among non‐Hispanic Whites, 14.0% Hispanics, 18.6% Blacks. that 2020, 6.07 CI 5.75–6.38) million were living AD, which increases to 13.85...
Context: Sex differences in risk of clinically diagnosed Alzheimer disease (AD) have been studied extensively, but little is known about the relation pathologic indices AD to clinical manifestations men compared with women.Objective: To test whether pathology differs and women.Design: Longitudinal, clinicopathologic cohort study.Participants Setting: Analyses were conducted on 141 older Catholic clergy members who underwent detailed annual evaluations brain autopsy at death.The number...
To test the hypothesis that years of formal education modifies relation AD pathology to level cognitive function.A total 130 older Catholic clergy participating in Religious Orders Study underwent annual function testing and brain autopsy at time death. Individual tests were z-scored averaged yield a global measure summary measures five different abilities. Neuritic diffuse plaques neurofibrillary tangles counted separate 1 mm(2) areas maximal density. Counts converted standard scores by...
To examine the relation of social resources and cognitive decline in older adults.Data are from Chicago Health Aging Project, an epidemiologic study risk factors for Alzheimer disease (AD) other common conditions a geographically defined population persons. The sample consisted 6,102 non-Hispanic African Americans (61.2%) whites, aged > or = 65, who underwent up to three interviews during average 5.3 years follow-up. Each interview included administration four function tests which composite...
<h3>Context</h3> Emerging data suggest that psychological and experiential factors are associated with risk of Alzheimer disease (AD), but the association purpose in life incident AD is unknown. <h3>Objective</h3> To test hypothesis greater a reduced AD. <h3>Design</h3> Prospective, longitudinal epidemiologic study aging. <h3>Setting</h3> Senior housing facilities residences across Chicago metropolitan area. <h3>Participants</h3> More than 900 community-dwelling older persons without...
Abstract We examined the association of social activity with cognitive decline in 1138 persons without dementia at baseline a mean age 79.6 ( SD = 7.5) who were followed for up to 12 years (mean 5.2; 2.8). Using mixed models adjusted age, sex, education, race, network size, depression, chronic conditions, disability, neuroticism, extraversion, activity, and physical more was associated less during average follow-up 5.2 2.7). A one point increase score (range 1–4.2; 2.6; 0.6) 47% decrease...
Cross-sectional and retrospective case-control studies suggest an association of depression symptoms with cognitive impairment AD, but there have been few prospective their results inconsistent.Participants are Catholic clergy members who were aged > or =65 years did not clinical evidence AD. During a 7-year period, they underwent annual evaluations that included classification AD detailed function testing from which global specific measures cognition derived. Number depressive was assessed...
Objective: To assess the association between purpose in life and all-cause mortality community-dwelling elderly persons. Methods: We used data from 1238 older persons without dementia two longitudinal cohort studies (Rush Memory Aging Project Minority Research Study) with baseline evaluations of up to 5 years follow-up test hypothesis that greater is associated a reduced risk among Results: The mean ± standard deviation score on measure at was 3.7 0.5 (range = 2–5), higher scores indicating...
Background and Purpose— Little is known about the role of microinfarcts in dementia cognition. We examined dementia, global cognition, 5 cognitive systems community-dwelling older persons. Methods— Four hundred twenty-five subjects enrolled Religious Orders Study underwent annual clinical evaluations, including 19 neuropsychological tests assessment for brain autopsy (39% men; mean age at death, 87; Mini-Mental State Examination score, 21). Neuropathologic examination documented presence,...
<h3>Objective:</h3> To determine the association between age at surgical menopause and both cognitive decline Alzheimer disease (AD) pathology in 2 longitudinal cohorts. <h3>Methods:</h3> Female subjects from studies of (Religious Orders Study Rush Memory Aging Project) were included (total n = 1,884). The primary analysis examined a global cognition score. Secondary analyses additional outcomes: 1) 5 subdomains 2) measure burden AD pathology. In exploratory analyses, we effect hormone...
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk Alzheimer's dementia, while APOE2 lower it not yet known whether homozygotes have particularly low risk. We generated dementia odds ratios and other findings in more than 5,000 clinically characterized neuropathologically cases controls. APOE2/2 was compared to APOE2/3 3/3, an exceptionally ratio APOE4/4, impact APOE4 gene dose significantly greater confirmed group 24,000 unconfirmed Finding...
We examined the association of diverse measures social engagement with level function in multiple cognitive domains 838 persons without dementia who had a mean age 80.2 (SD = 7.5). Social network size, frequency activity, and perceived support were assessed linear regression models adjusted for age, sex, education, other covariates. activity related to better function, whereas size was not strongly global cognition. The results confirm that higher old is associated but varies across engagement.
Community-based cohorts of older persons may differ neuropathologically from clinic-based cohorts. This study investigated age-related pathologies in with and without dementia included autopsied participants two community-based cohorts, the Rush Religious Orders Study (n=386) Memory Aging Project (n=195), one cohort, Clinical Core Alzheimer's Disease Center (n=392). Final clinical diagnoses no cognitive impairment (n=202), mild (MCI) (n=150), probable disease (AD) (n=474), possible AD...
Level of education is a well-established risk factor for Alzheimer disease but its relation to cognitive decline, the principal clinical manifestation disease, uncertain.More than 6,000 older residents community on south side Chicago were interviewed at approximately 3-year intervals up 14 years. The interview included administration four brief tests function from which previously established composite measure global cognition was derived. We estimated associations with baseline level and...
We examined the relation of individual-level perceived discrimination to mortality in a biracial, population-based sample.