A5050670369- Nutritional Studies and Diet
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Folate and B Vitamins Research
- Alzheimer's disease research and treatments
- Fatty Acid Research and Health
- Antioxidant Activity and Oxidative Stress
- Obesity, Physical Activity, Diet
- Nutrition and Health in Aging
- Fluoride Effects and Removal
- Frailty in Older Adults
- Consumer Attitudes and Food Labeling
- Health, Environment, Cognitive Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood Pressure and Hypertension Studies
- Nutrition, Genetics, and Disease
- Alcoholism and Thiamine Deficiency
- Olfactory and Sensory Function Studies
- Pelvic floor disorders treatments
- Health disparities and outcomes
- Neurological Disease Mechanisms and Treatments
- Trace Elements in Health
- Sodium Intake and Health
- Neurological diseases and metabolism
- GDF15 and Related Biomarkers
Rush University Medical Center
2014-2024
Rush University
2014-2024
Hospital for Sick Children
2024
California University of Pennsylvania
2024
Washington University in St. Louis
2024
Johns Hopkins University
2024
Brigham and Women's Hospital
2024
Cleveland Clinic
2024
Tufts University
2017-2020
Jean Mayer Human Nutrition Research Center on Aging
2020
<h3>Background</h3> Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type fat protects against Alzheimer disease. <h3>Objective</h3> To examine fish consumption and intake different types protect <h3>Design</h3> Prospective conducted from 1993 through 2000, a stratified random sample geographically defined community. Participants were followed up for an average 3.9 years the development <h3>Patients</h3> A total...
In a previous study, higher concordance to the MIND diet, hybrid Mediterranean-Dietary Approaches Stop Hypertension was associated with slower cognitive decline. this study we related these three dietary patterns incident Alzheimer's disease (AD).We investigated diet-AD relations in prospective of 923 participants, ages 58 98 years, followed on average 4.5 years. Diet assessed by semiquantitative food frequency questionnaire.In adjusted proportional hazards models, second (hazards ratio or...
The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific the nutrition literature on dementia prevention.
ContextOxidative processes have been suggested as elements in the development of Alzheimer disease (AD), but whether dietary intake vitamin E and other antioxidant nutrients prevents its is unknown.ObjectiveTo examine nutrients, E, C, beta carotene associated with incident AD.Design, Setting, ParticipantsProspective study, conducted from 1993 to 2000, individuals selected a stratified random sample community-dwelling residents. The 815 residents 65 years older were free AD at baseline...
Few studies have investigated the effects of dietary fats on development Alzheimer disease. We examined associations between intake specific types fat and incident disease in a biracial community study.We performed clinical evaluations stratified random sample 815 residents aged 65 years older who were unaffected by at baseline completed food-frequency questionnaire mean 2.3 before evaluation.After follow-up 3.9 years, 131 persons developed Intakes saturated trans-unsaturated positively...
Participation in cognitively stimulating activities is hypothesized to be associated with risk of AD, but knowledge about this association limited.A biracial community Chicago was censused, persons aged 65 years and older were asked participate an interview, 6,158 7,826 (79%) eligible did so. As part the rated current frequency participation seven cognitive (e.g., reading a newspaper) nine physical walking for exercise) from which composite measures activity derived. Four later, 1,249 those...
Dietary intake of fish and the omega-3 fatty acids have been associated with lower risk Alzheimer disease stroke.To examine whether intakes protect against age-related cognitive decline.Prospective cohort study.Geographically defined Chicago, Ill, community.Residents, 65 years older, who participated in Chicago Health Aging Project.Change a global score estimated from mixed models. The was computed by summing scores 4 standardized tests. In-home assessments were performed 3 times over 6...
Abstract Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population society as whole. With numbers of people with ADRDs predicted to rise dramatically across world, scientific community can no longer neglect need for research focusing on among underrepresented ethnoracial diverse groups. The Association International Society Advance Research Treatment (ISTAART; alz.org/ISTAART ) comprises number professional interest areas (PIAs), each major area...
To examine the association between rates of cognitive change and dietary consumption fruits vegetables among older persons.The authors conducted a prospective cohort study 3,718 participants, aged 65 years Chicago Health Aging Project. Participants completed food frequency questionnaire were administered at least two three assessments baseline, 3-year, 6-year follow-ups. Cognitive function was measured using average z-score four tests: East Boston Tests immediate memory delayed recall,...
Alzheimer's disease (AD) is generally associated with lower omega-3 fatty acid intake from fish but despite numerous studies, it still unclear whether there are differences in acids plasma or brain. In matched and brain sam
We examined whether accordance to the DASH (Dietary Approach Stop Hypertension) and Mediterranean diets is associated with slower cognitive decline in a prospective Chicago cohort study of older persons, Memory Aging Project.The sample comprised 826 Project participants (aged 81.5 ± 7.1 years) who completed 144-item food frequency questionnaire at baseline 2 or more assessments over 4.1 years. Dietary scores were computed for diet (0-10) (MedDietScore) (0-55). For both, higher reflect...
To increase understanding of the biological mechanisms underlying association, we investigated individual relations to cognitive decline primary nutrients and bioactives in green leafy vegetables, including vitamin K (phylloquinone), lutein, β-carotene, nitrate, folate, kaempferol, α-tocopherol.This was a prospective study 960 participants Memory Aging Project, ages 58-99 years, who completed food frequency questionnaire had ≥2 assessments over mean 4.7 years.In linear mixed model adjusted...
To quantify the impact of a healthy lifestyle on risk Alzheimer dementia.Using data from Chicago Health and Aging Project (CHAP; n = 1,845) Rush Memory (MAP; 920), we defined score basis nonsmoking, ≥150 min/wk moderate/vigorous-intensity physical activity, light to moderate alcohol consumption, high-quality Mediterranean-DASH Diet Intervention for Neurodegenerative Delay diet (upper 40%), engagement in late-life cognitive activities giving an overall ranging 0 5. Cox proportional hazard...
To determine whether dietary intake of flavonols is associated with Alzheimer dementia.The study was conducted among 921 participants the Rush Memory and Aging Project (MAP), an ongoing community-based, prospective cohort. Participants completed annual neurologic evaluations assessments using a validated food frequency questionnaire.Among MAP who initially had no dementia in analyzed sample, 220 developed dementia. The mean age sample 81.2 years (SD 7.2), majority (n = 691, 75%) being...
Findings from observational studies suggest that dietary patterns may offer protective benefits against cognitive decline, but data clinical trials are limited. The Mediterranean–DASH Intervention for Neurodegenerative Delay, known as the MIND diet, is a hybrid of Mediterranean diet and DASH (Dietary Approaches to Stop Hypertension) with modifications include foods have been putatively associated decreased risk dementia. Download PDF Research Summary. We performed two-site, randomized,...
This paper is a proposal for an update of the iron hypothesis Alzheimer's disease (AD), based on large-scale emerging evidence.