Ralph N. Martins
A5065618928- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Cholinesterase and Neurodegenerative Diseases
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Frailty in Older Adults
- Menopause: Health Impacts and Treatments
- Computational Drug Discovery Methods
- Folate and B Vitamins Research
- S100 Proteins and Annexins
- Bioinformatics and Genomic Networks
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Prion Diseases and Protein Misfolding
- Metabolomics and Mass Spectrometry Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Hormonal and reproductive studies
- Estrogen and related hormone effects
Australian Alzheimer’s Research Foundation
2016-2025
Macquarie University
2016-2025
Edith Cowan University
2016-2025
Murdoch University
2014-2025
Universidade de São Paulo
2025
Hollywood Private Hospital
2013-2024
Austin Health
2010-2024
Dementia Australia
2008-2024
CSIRO Health and Biosecurity
2016-2024
Avenir Health
2022-2024
The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the develops over many years. Autosomal dominant has a predictable age at onset provides an opportunity to determine sequence changes that culminate symptomatic disease.
The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment cohort gives information about methodology, baseline demography, diagnoses, medical comorbidities, medication use, cognitive function participants.Volunteers underwent a screening interview, had comprehensive testing, gave 80 ml blood, completed health lifestyle...
Abstract Objective Assess Aβ deposition longitudinally and explore its relationship with cognition disease progression. Methods Clinical follow‐up was obtained 20 ± 3 months after [ 11 C]Pittsburgh compound B (PiB)‐positron emission tomography in 206 subjects: 35 dementia of the Alzheimer type (DAT), 65 mild cognitive impairment (MCI), 106 age‐matched healthy controls (HCs). A second PiB scan at 185 subjects a third years 57. Results At baseline, 97% DAT, 69% MCI, 31% HC showed high...
In patients with Alzheimer's disease, amyloid fibrils that are aggregates of A4 protein subunits deposited in the brain. A similar process occurs at an earlier age persons Down's syndrome. To investigate deposition these diseases, we used a radioimmunoassay to measure levels precursor (PreA4) serum 17 syndrome, 15 and 33 normal elderly controls. The mean (±SD) concentration PreA4 was increased 1.5-fold syndrome (2.49±1.13 nmol per liter) as compared controls (1.68±0.49 liter; P<0.007);...
White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression Alzheimer's disease (AD). These observations typically interpreted as evidence vascular abnormalities play an additive, independent role contributing to symptom presentation, but not core features AD. We examined the severity distribution in...
Abstract Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population society as whole. With numbers of people with ADRDs predicted to rise dramatically across world, scientific community can no longer neglect need for research focusing on among underrepresented ethnoracial diverse groups. The Association International Society Advance Research Treatment (ISTAART; alz.org/ISTAART ) comprises number professional interest areas (PIAs), each major area...
Longitudinal cerebrospinal fluid biomarker analyses reveal decreases in neuronal injury markers later stages of autosomal-dominant Alzheimer’s disease.
Background The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)‐42, total‐tau (T‐tau), and phosphorylated‐tau (P‐tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, within laboratories. Association has initiated a global quality control program to estimate monitor variability of measurements, quantify batch‐to‐batch assay variations, identify sources variability. In this article, we present...
The histologic diagnosis of Alzheimer9s disease (AD) might be aided if a more sensitive marker aberrant A4 amyloid protein deposition were available. We screened sample aged brains, using immunocytochemical methods to detect the deposition, and found that, in comparison with conventional techniques (silver impregnation Congo red), immunocytochemistry is allows an easier demarcation between "normal" "abnormal." If accepted as definitive for AD, then age-related prevalence AD increases...
Elucidating the role of aggregated beta-amyloid in relation to gray matter atrophy is crucial understanding pathological mechanisms Alzheimer disease and for development therapeutic trials. The present study aims assess this relationship.Brain magnetic resonance imaging [(11)C]Pittsburgh compound B (PiB)-positron emission tomography scans were obtained from 94 healthy elderly subjects (49 with subjective cognitive impairment), 34 patients mild impairment, 35 disease. correlations between...
To investigate the associations of metformin, serum vitamin B12, calcium supplements, and cognitive impairment in patients with diabetes.Participants were recruited from Primary Research Memory (PRIME) clinics study, Australian Imaging, Biomarkers Lifestyle (AIBL) study aging, Barwon region southeastern Australia. Patients Alzheimer disease (AD) (n=480) or mild (n=187) those who cognitively intact (n=687) included; stroke neurodegenerative diseases other than AD excluded. Subgroup analyses...
Abstract Reducing the risk of dementia can halt worldwide increase affected people. The multifactorial and heterogeneous nature late‐onset dementia, including Alzheimer's disease (AD), indicates a potential impact multidomain lifestyle interventions on reduction. positive results landmark Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) support such an approach. World‐Wide FINGERS (WW‐FINGERS), launched in 2017 over 25 countries, is first global...
Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering these biomarkers prior to dementia remains untested. In a cohort with disease mutations, we performed an integrated whole-brain analysis three major imaging techniques: amyloid PET, [ 18 F]fluro-deoxyglucose structural MRI. We found that most gray-matter structures plaques later have hypometabolism followed by atrophy. Critically,...