A5043507711- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Ophthalmology and Eye Disorders
- Advanced Neuroimaging Techniques and Applications
- Frailty in Older Adults
- Vestibular and auditory disorders
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Spatial Neglect and Hemispheric Dysfunction
- Advanced MRI Techniques and Applications
- Nutritional Studies and Diet
- Stroke Rehabilitation and Recovery
- Cancer-related molecular mechanisms research
- Cerebrospinal fluid and hydrocephalus
- Cancer-related Molecular Pathways
- Health and Wellbeing Research
- Nutrition and Health in Aging
- Cholinesterase and Neurodegenerative Diseases
- Epilepsy research and treatment
- Acute Ischemic Stroke Management
- RNA modifications and cancer
- Cerebral Venous Sinus Thrombosis
- Software Engineering Research
Ajou University
2016-2025
Evidence Based Research (United States)
2025
Ajou University Hospital
2013-2024
Sungkyunkwan University
2003-2023
Samsung Medical Center
2003-2023
Pusan National University Yangsan Hospital
2023
Hanyang University
2023
Pusan National University Hospital
2023
Hallym University
2021
Institut national de recherche en informatique et en automatique
2018
Abstract Reducing the risk of dementia can halt worldwide increase affected people. The multifactorial and heterogeneous nature late‐onset dementia, including Alzheimer's disease (AD), indicates a potential impact multidomain lifestyle interventions on reduction. positive results landmark Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) support such an approach. World‐Wide FINGERS (WW‐FINGERS), launched in 2017 over 25 countries, is first global...
Benign paroxysmal positional vertigo (BPPV) is characterized by episodic and nystagmus provoked head motions. To study the characteristics of BPPV in a large group patients Korea, we retrospectively analyzed clinical features 1,692 (women: 1,146, 67.7%; men: 54.6, 32.3%; mean age: 54.8+/-14.0 yr), who had been diagnosed as trained neuro-otologists Dizziness Clinics. The diagnosis was based on typical elicited positioning maneuvers. Posterior semicircular canal involved 60.9% patients,...
<b><i>Background:</i></b> We examined the efficacy of group-based cognitive intervention (GCI) and home-based (HCI) in amnestic mild impairment (aMCI) effects on serum brain-derived neurotrophic factor (BDNF). <b><i>Methods:</i></b> In this randomized rater-blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to GCI group, 98 HCI group 99 control group. For 12 weeks, subjects receiving participated twice per...
Abstract Background Neuropsychological tests (NPTs) are important tools for informing diagnoses of cognitive impairment (CI). However, interpreting NPTs requires specialists and is thus time-consuming. To streamline the application in clinical settings, we developed evaluated accuracy a machine learning algorithm using multi-center NPT data. Methods Multi-center data were obtained from 14,926 formal neuropsychological assessments (Seoul Screening Battery), which classified into normal...
White matter hyperintensity (WMH) lesions on brain MRI images are surrogate markers of cerebral small vessel disease. Longitudinal studies examining the association between diabetes and WMH progression have yielded mixed results. Thus, in this study, we investigated HbA1c, a biomarker for presence severity hyperglycemia, longitudinal change after adjusting known risk factors progression. We recruited 64 participants from South Korean memory clinics to undergo at baseline 2-year follow-up....
To determine patterns of nystagmus in oculopalatal tremor (OPT, also designated myoclonus) and correlate them with MRI changes the inferior olivary nuclei (ION). Mixed torsional-vertical pendular (PN) OPT has been considered to signify unilateral brainstem damage symmetric vertical indicate bilateral disease.Ocular oscillations were analyzed 22 patients OPT, 20 from focal lesions, or without cerebellar two progressive ataxia palatal syndrome. was performed all patients.Patients had mainly...
Center for Dementia of South Korea) StudyWith rapid population aging, the socioeconomic burden caused by dementia care is snowballing.Although a few community-based studies Alzheimer's disease (AD) have been performed in Korea, there has never nationwide hospital-based study thereof.We aimed to identify demographics and clinical characteristics mild-to-moderate AD patients from Clinical Research Korea (CREDOS) registry.A total 1,786 were consecutively included September 2005 June 2010.Each...
This study explored whether religiosity/spirituality has a protective role against negative caregiving outcomes, in large multicenter nationwide sample of caregivers patients with dementia South Korea. Additionally, this was the first to examine could affect outcomes according various religious affiliations caregivers.The conducted on 476 participated Clinical Research Center for Dementia Korea (CREDOS). We examined moderating effect each three dimensions (organizational activity, ORA;...
Aging | doi:10.18632/aging.203213. So Young Moon, Chang Hyung Hong, Jee Hyang Jeong, Yoo Kyoung Park, Hae Ri Na, Hong-Sun Song, Byeong C. Kim, Kyung Won Hee Muncheong Choi, Sun Min Lee, Buong-O Chun, Seong-Ho Koh, Ah Hyun-Hee Jeong-Hwa Jin, Eun-Hye Sue Song Mi Han, Jun Seok Jungsoon Ha, Seong Hye Choi
Horizontal canal benign paroxysmal positional vertigo is characterized by horizontal direction-changing nystagmus induced lateral head turning in supine position. According to Ewald's second law, the direction of that creates a stronger response represents affected side geotropic and healthy apogeotropic nystagmus. However, it may not always be possible lateralize involved ear only comparing intensity We studied values position change from sitting lateralization vertigo.A retrospective study...
ABSTRACT Background: Highly educated participants with normal cognition show lower incidence of Alzheimer's disease (AD) than poorly participants, whereas longitudinal studies involving AD have reported that higher education is associated more rapid cognitive decline. We aimed to evaluate whether highly amnestic mild impairment (aMCI) decline those levels education. Methods: A total 249 aMCI patients enrolled from 31 memory clinics using the standard assessment and diagnostic processes were...
The association between white matter changes and activities of daily living (ADL) in a large, well-defined cohort patients with mild-to-moderate dementia (either Alzheimer’s disease or subcortical vascular dementia) were investigated. A total 289 divided into three groups (140 mild, 99 moderate, 50 severe) depending on the degree as indicated brain magnetic resonance image scans. Further, we analyzed groups’ performances basic instrumental ADL. was associated greater age, hypertension,...
ABSTRACT Background: Personality may predispose family caregivers to experience caregiving differently in similar situations and influence the outcomes of caregiving. A limited body research has examined role some personality traits for health-related quality life (HRQoL) among persons with dementia (PWD) relation burden depression. Methods: Data from a large clinic-based national study South Korea, Caregivers Alzheimer's Disease Research (CARE), were analyzed ( N = 476). Path analysis was...
Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether increases the in senior patients T2DM.We used Korean National Health Insurance Service Senior cohort, which includes >10% entire population South Korea. In total, 5,966 who had ever experienced at least one episode were matched those not, using propensity score matching. was assessed through a survival analysis pairs.Patients...
Abstract We previously developed a novel machine-learning-based brain age model that was sensitive to amyloid. aimed independently validate it and demonstrate its utility using independent clinical data. recruited 650 participants from South Korean memory clinics undergo magnetic resonance imaging assessments. employed pretrained used data an set of largely Caucasian individuals ( n = 757) who had no or relatively low levels amyloid as confirmed by positron emission tomography (PET)....
The SoUth Korea study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention (SUPERBRAIN) proved the feasibility of multidomain for elderly people. One-quarter Korean population over 65 years age has mild impairment (MCI). Digital interventions may be cost-effective have fewer spatial constraints. We aim examine efficacy a both face-to-face interactions video communication platforms using tablet personal computer (PC) application in MCI.
This study aimed to establish the optimal cutoff values for visual amyloid positivity using standardized uptake value ratios (SUVRs) in [18F]flutemetamol (FMM) positron emission tomography (PET) imaging. Given variability assessment, our goal was determine that enhance diagnostic accuracy and assist clinicians reliably identifying positivity. The identified were > 1.6 cerebellar gray matter, 1.38 whole cerebellum, 0.63 pons, yielding high sensitivity (95.5%, 94.5%, 95.8%, respectively)...