A5078158233- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological diseases and metabolism
- Neurological Disease Mechanisms and Treatments
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Genetic Neurodegenerative Diseases
- Frailty in Older Adults
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Amyotrophic Lateral Sclerosis Research
- Health and Wellbeing Research
- Listeria monocytogenes in Food Safety
- Nutrition and Health in Aging
- Infectious Diseases and Mycology
- Viral gastroenteritis research and epidemiology
- Ocular Diseases and Behçet’s Syndrome
- Health disparities and outcomes
- Hepatitis C virus research
Seoul National University
2018-2024
University College London
2021-2024
Deleted Institution
2024
Ewha Womans University
2019-2023
Mental Health Research UK
2021-2023
BioSurfaces (United States)
2020
Vikram Hospital
2019
Ewha Womans University Medical Center
2019
Inje University Ilsan Paik Hospital
2010-2018
Yonsei University
2015-2018
<h3>Objective:</h3> To investigate the topographic changes of white matter (WM) integrity and cortical thickness related to gait disturbances determine whether these neural correlates mediate association between cerebral small vessel disease (CSVD) disturbances. <h3>Methods:</h3> A total 129 patients with subcortical vascular cognitive impairment were included. CSVD severity was quantified as global regional WM hyperintensities (WMH) volume lacune microbleed numbers. Amyloid burdens assessed...
ABSTRACT We evaluated the usefulness of PCR assays that target internal transcribed spacer (ITS) region for identifying mycobacteria at species level. The conservative and species-specific ITS sequences 33 were analyzed in a multialignment analysis. One pair panmycobacterial primers seven pairs mycobacterial designed. All PCRs performed under same conditions. specificities tested with type strains 20 from American Type Culture Collection; 205 clinical isolates mycobacteria, including 118...
Center for Dementia of South Korea) StudyWith rapid population aging, the socioeconomic burden caused by dementia care is snowballing.Although a few community-based studies Alzheimer's disease (AD) have been performed in Korea, there has never nationwide hospital-based study thereof.We aimed to identify demographics and clinical characteristics mild-to-moderate AD patients from Clinical Research Korea (CREDOS) registry.A total 1,786 were consecutively included September 2005 June 2010.Each...
To determine the independent and synergistic effects of amyloid small vessel disease (SVD) burden on longitudinal cognitive decline in patients with subcortical vascular dementia (SVaD).A cohort study was conducted involving from outpatient clinics 2 tertiary referral centers. Sixty-one SVaD were prospectively recruited underwent MRI, 11C-Pittsburgh compound B (PiB) PET at baseline, a 3-year annual neuropsychological follow-up. Effects PiB positivity SVD markers (white matter...
Aging | doi:10.18632/aging.203213. So Young Moon, Chang Hyung Hong, Jee Hyang Jeong, Yoo Kyoung Park, Hae Ri Na, Hong-Sun Song, Byeong C. Kim, Kyung Won Hee Muncheong Choi, Sun Min Lee, Buong-O Chun, Seong-Ho Koh, Ah Hyun-Hee Jeong-Hwa Jin, Eun-Hye Sue Song Mi Han, Jun Seok Jungsoon Ha, Seong Hye Choi
<ns3:p>Obesity and short sleep duration have both been associated with an increased risk of dementia, but their combined impact the underlying mechanisms are not yet fully understood. Our aim is to investigate separate associations obesity cognitive decline dementia risk, whether these mediated by neuroinflammatory responses metabolic disturbances, as indicated blood-based biomarkers. This a prospective cohort study adults who were free had data on BMI at baseline in 1997-1999, tracked for...
Background & Objective: Early-onset Alzheimer's disease (EOAD, onset age < 65 years) may differ from late-onset (LOAD) in terms of cognitive profiles and neuropsychiatric symptoms. There have been few studies for Korean EOA
<strong>Background:</strong> Acquired hepatocerebral degeneration (AHD) refers to a chronic neurological syndrome in patients with advanced hepatobiliary diseases. This comprehensive review focuses on the pathomechanism and neuroimaging findings AHD. <strong>Methods:</strong> A PubMed search was performed using terms ''acquired degeneration,'' ''chronic ''Non-Wilsonian ''cirrhosis-related parkinsonism,'' ''manganese liver disease.'' <strong>Results:</strong> Multiple mechanisms involving...
ABSTRACT Identification of pathogenic Mycobacterium species is important for a successful diagnosis mycobacteriosis. The purpose this study was to develop an oligonucleotide array which could detect and differentiate mycobacteria the level by using internal transcribed spacer (ITS) sequence. Using genus-specific probe 20 species-specific probes including two M. avium-intracellulare complex (MAC)-specific probes, we have developed ITS-based rapid reliable detection discrimination tuberculosis...
Abstract: Background: Visual hallucination (VH) is a common psychotic symptom in patients with Parkinson's disease (PD) and may be significant predictor of cognitive impairment (CI) such patients. Objective: This study aimed to investigate the pattern glucose metabolism VH relationship between CI PD. Methods: We studied 28 PD patients, including 15 (PD-VH) 13 without (PD-NVH). Of PD-VH 8 had (PD-VHCI) whereas 7 did not (PD-VHNCI). All underwent [ 18 F] fluorodeoxyglucose positron emission...
In the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated impact of a 24-week facility-based multidomain (FMI) home-based MI (HMI) on cortical thickness, brain volume, serum brain-derived neurotrophic factor (BDNF). Totally, 152 participants, aged 60-79 years without dementia but with ≥ 1 modifiable risk factor, were randomly assigned FMI, HMI, or control groups. Among them, 55...
The SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN) is a part of the World-Wide Finnish Geriatric Intervention Study Prevent Cognitive Impairment Disability (WW-FINGERS) network. This aimed demonstrate effects SUPERBRAIN-based multidomain with nutritional supplements amyloid positive emission tomography (PET) proven early symptomatic Alzheimer's disease patients.Forty-six participants who were...
It has been reported that washing seeds with a 20000 ppm Ca(OCl)(2) solution as recommended by the U.S. Food and Drug Administration is unable to eliminate E. coli cells attached seed surfaces, bacterial have survived sanitation wash can proliferate during sprouting high population. The objectives of this research were examine efficacy malic acid (MA) thiamine dilauryl sulfate (TDS) combined treatments on inactivation O157:H7 alfalfa seeds, study growth remaining sprouting, evaluate sprout...
Pure akinesia with gait freezing (PAGF) is a clinical syndrome characterized by of gait, handwriting, and speech without abnormal eye movement or cognitive impairment. Several studies have suggested that PAGF may be variant progressive supranuclear palsy (PSP). However, the characteristics striatal dopamine transporter loss in are unknown.To investigate subregional pattern patients comparison PSP those Parkinson disease (PD).This retrospective case-control study included 15 PAGF, 27 PD, 20...
The prevalence of dementia is increasing in South Korea. Multidomain interventions may be useful for preventing dementia. Such programs need to disseminated elderly Koreans throughout the country. We have developed SoUth Korean study PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention at-risk people (SUPERBRAIN), which consists a facility-based multidomain (FMI) program home-based (HMI) suitable Koreans. aim determine feasibility SUPERBRAIN before large-scale...
Cefepime is a fourth-generation B-lactam cephalosporin, commonly used in immunosuppressed patients.Neurotoxicity, which present as nonconvulsive status epilepticus (NCSE), has been reported previously especially adult patients with impaired renal function.We case of cefepime induced NCSE after recovering from acute failure.A 71-year-old woman was hospitalized for right lower lobe lobectomy diagnosis lung cancer.Although she had successful lobectomy, underwent several post operative...
Background and PurposezzDisability-adjusted life years (DALY), incorporating both disability mortality, has been widely employed to measure regional global burdens of stroke.Thus far, the DALY lost stroke in a population estimated using only crude population-level data; no previous study incorporated refined data from registries.The aim this was integrate registry incidence project nationwide ischemic stroke.MethodszzFrom two large registries, we derived an average due for each following age...
Nonmotor symptoms (NMS) in Parkinson's disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on health-related quality life (HrQoL). We aimed to determine presentation according PD status, and associations other clinical variables HrQoL Korean patients.We surveyed patients 37 movement-disorders clinics Korea. In total, 323 were recruited for assessment severity duration,...
Typically, progressive supranuclear palsy (PSP) is clinically characterized by slow vertical saccades or gaze palsy, levodopa-resistant parkinsonism with predominant axial symptoms, and cognitive executive impairment. Over the past decades, various PSP phenotypes, including parkinsonism, corticobasal syndrome, gait freezing, frontal dysfunction, have been identified from pathologically confirmed cases. Expanding knowledge led to new diagnostic criteria for that increased disease awareness...