A5004207965- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Neurological diseases and metabolism
- Restless Legs Syndrome Research
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Neurosurgical Procedures and Complications
- Genetic Associations and Epidemiology
- Intracerebral and Subarachnoid Hemorrhage Research
- Dysphagia Assessment and Management
- Neurological and metabolic disorders
- Mitochondrial Function and Pathology
- Lysosomal Storage Disorders Research
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- CRISPR and Genetic Engineering
- Alzheimer's disease research and treatments
- Head and Neck Surgical Oncology
- Trace Elements in Health
- Parkinson's Disease and Spinal Disorders
- Heavy Metal Exposure and Toxicity
- Glycogen Storage Diseases and Myoclonus
University of Ulsan
2016-2025
Asan Medical Center
2016-2025
Ulsan College
2016-2025
ElSohly Laboratories (United States)
2025
Yonsei University
2021-2024
Samsung Medical Center
2024
Sungkyunkwan University
2024
Seoul National University
1995-2024
Inje University
2024
Inserm
2024
Drug-induced parkinsonism (DIP) is the second-most-common etiology of in elderly after Parkinson's disease (PD). Many patients with DIP may be misdiagnosed PD because clinical features these two conditions are indistinguishable. Moreover, neurological deficits severe enough to affect daily activities and persist for long periods time cessation drug taking. In addition typical antipsychotics, caused by gastrointestinal prokinetics, calcium channel blockers, atypical antiepileptic drugs. The...
Parkinson disease (PD), progressive supranuclear palsy (PSP), and multiple-system atrophy (MSA) are known to affect dopaminergic neurons of the brain stem striatum with different preferential involvement. Here we investigated differences in striatal subregional dopamine transporter loss PD, PSP, MSA assessed diagnostic value <sup>18</sup>F-fluorinated-<i>N</i>-3-fluoropropyl-2-β-carboxymethoxy-3-β-(4-iodophenyl)nortropane (<sup>18</sup>F-FP-CIT) PET differentiating PSP from PD....
As the most feasible solution beyond FinFET technology, a gate-all-around Multi-Bridge-Channel MOSFET (MBCFET) technology is successfully demonstrated including fully working high density SRAM. MBCFETs are fabricated using 90% or more of processes with only few revised masks, allowing easy migration from process. Not on-target but also multiple Vt achieved in challengingly limited vertical spacing between channels. Also, reliability shown to be comparable that FinFETs. Three representative...
<h3>Importance</h3> The development of Parkinson disease (PD) may be promoted by exposure to air pollution. <h3>Objective</h3> To investigate the potential association between particulate matters (PM<sub>2.5</sub>and PM<sub>10</sub>), nitrogen dioxide (NO<sub>2</sub>), ozone (O<sub>3</sub>), sulfur (SO<sub>2</sub>), and carbon monoxide (CO) risk incident PD. <h3>Design, Setting, Participants</h3> This retrospective cohort study used data from Korean National Health Insurance Service. Among 1...
Mitochondrial function influences Parkinson's disease (PD) through the accumulation of pathogenic alpha-synuclein, oxidative stress, impaired autophagy, and neuroinflammation. The mitochondrial DNA copy number (mtDNA-CN), representing copies within a cell, serves as an easily assessable proxy for function.
To investigate clinical, MRI, and radioisotope findings therapeutic outcome of the syndrome CSF hypovolemia.Retrospective review was performed 30 consecutive patients (10 men, 20 women; mean age 37 years) with hypovolemia.All had an orthostatic headache, which alleviated to a variable extent on recumbency. Additional clinical symptoms included nausea, dizziness, neck stiffness, blurring vision, tinnitus, plugged ear, hearing difficulties radicular pain arm. Eighty-two percent opening...
Abstract Background Supine recumbence has been widely performed to prevent post-lumbar puncture headache (PLPH). However, the optimal duration of supine is controversial. The aim study compare occurrence PLPH according in patients with neurological disorders. Methods A non-equivalent control/experimental pre-/post-test design was used. Seventy consecutive were prospectively enrolled between July 2007 and 2008. Thirty-five underwent for four hours after lumbar (Group 1) 35 one hour 2)....
Genome-wide association studies (GWAS) on Parkinson's disease (PD) have mostly been done in Europeans and Japanese. No study has Han Chinese, which make up nearly a fifth of the world population. We conducted first Chinese GWAS analysing total 22,729 subjects (5,125 PD cases 17,604 controls) from Singapore, Hong Kong, Malaysia, Korea, mainland China Taiwan. performed imputation, merging logistic regression analyses 2,402,394 SNPs passing quality control filters 779 cases, 13,227 controls,...
Although several studies have identified a distinct gut microbial composition in Parkinson's disease (PD), few investigated the oral microbiome or functional alteration of PD. We aimed to investigate connection between and changes PD-specific using shotgun metagenomic sequencing. The taxonomic was significantly different PD patients healthy controls (P = 0.003 0.001, respectively). Oral Lactobacillus more abundant associated with opportunistic pathogens (FDR-adjusted P < 0.038). Functional...
Parkinson’s disease (PD) is a progressive neurodegenerative disorder. However, cell type–dependent transcriptional regulatory programs responsible for PD pathogenesis remain elusive. Here, we establish transcriptomic and epigenomic landscapes of the substantia nigra by profiling 113,207 nuclei obtained from healthy controls patients with PD. Our multiomics data integration provides type annotation 128,724 cis-regulatory elements (cREs) uncovers type–specific dysregulations in cREs strong...
Background and Purpose— An extradurally located cavernous sinus dural arteriovenous fistula (CSDAVF) exhibits different clinical behavior from other fistulas (DAVFs) between 2 leaves. The aim of this study is to define angiographic types CSDAVF associated with presenting symptom (Sx) venous drainage patterns. Methods— CSDAVFs during a mean 23-month follow-up period 58 patients (17 73 years, male:female ratio=8:50) were retrospectively analyzed. 3 CSDAF, ie, proliferative (PT), restrictive...
The aims of this study was to investigate the effects visual and auditory cues on freezing gait in Parkinson disease patients (PDF) compared with without (PDNF).Fifteen PDF, 10 PDNF, age-matched healthy volunteers were recruited. Subjects walked back forth a 7-m walkway under three different conditions: baseline condition cues, cues. Visual consisted white stripes located along walkway. For metronome used. Gait analyzed using three-dimensional computerized analysis.In PDF group, both...
Gastric and colonic alpha-synuclein immunoreactivity has been reported in patients with Parkinson's disease (PD). However, enteric also healthy individuals.We aimed to investigate the utility of from gastric mucosal tissues obtained by routine endoscopy detect PD, correlate pathological burden motor nonmotor features PD.We recruited 104 study subjects, consisting 38 13 probable multiple system atrophy (MSA), 53 controls. endoscopic gastroduodenoscopy colonoscopy were assessed using...
<h3>Importance</h3> Pathogenic variants in<i>LRRK2</i>are a relatively common genetic cause of Parkinson disease (PD). Currently, the molecular mechanism underlying is unknown, and gain loss function (LOF) models pathogenesis have been postulated.<i>LRRK2</i>variants are reported to result in enhanced phosphorylation substrates increased cell death. However, double knockout of<i>Lrrk2</i>and its homologue<i>Lrrk1</i>results neurodegeneration mouse model, suggesting that may occur by LOF....
Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility these associations may be explained by reverse causation.To examine using two-sample Mendelian randomisation (MR) and potential for survival incidence-prevalence biases.We used summary statistics from publicly available to estimate association genetic polymorphisms behaviors, Courage-PD (7,369 cases,...
<h3>Objective</h3> We developed and investigated the feasibility of a machine learning–based automated rating for 2 cardinal symptoms Parkinson disease (PD): resting tremor bradykinesia. <h3>Methods</h3> Using OpenPose, deep human pose estimation program, we analyzed video clips finger tapping bilateral upper limbs 55 patients with PD (110 arms). Key motion parameters, including amplitude speed, amplitude, fatigue, were extracted to develop automatic Unified Parkinson9s Disease Rating Scale...
Abstract Background Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association causal or explained by reverse causation confounding. Objective The aim to examine the between genetically predicted and PD using two‐sample Mendelian randomization (MR). Methods We genotyped well‐established instrumental variable located lactase gene (rs4988235) within Courage‐PD consortium (23 studies; 9823...
Article AbstractBackground: Cardiovascular side effects ofclozapine are not uncommon, but few systematic studies of theseeffects have been performed. In this study, we reviewed data onthe electrocardiographic (ECG) abnormalities in patients treatedwith clozapine. Method: Sixty-one treated withclozapine were selected from the Seoul National UniversityHospital Treatment-Resistant Schizophrenia Clinic. A retrospective chart review was conducted to identify ECGabnormalities and cardiovascular...
To investigate the bilateral effects of unilateral subthalamic nucleus deep brain stimulation (STN-DBS), we prospectively studied 9 consecutive advanced Parkinson's disease (PD) patients (2 men and 7 women) who underwent STN-DBS. Patients were evaluated preoperatively at 3 6 months postoperatively with without dopaminergic medications ('on' 'off' medication, respectively). Postoperatively, assessed stimulation. We found that, when compared baseline, medication scores Unified Disease Rating...