A5064459397- Medical Imaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Head and Neck Cancer Studies
- Alzheimer's disease research and treatments
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Glioma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Head and Neck Surgical Oncology
- Cerebrovascular and Carotid Artery Diseases
- Radiopharmaceutical Chemistry and Applications
- Neurological Disorders and Treatments
- Cancer Diagnosis and Treatment
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Neurological and metabolic disorders
- Gallbladder and Bile Duct Disorders
- Ear and Head Tumors
University of Ulsan
2016-2025
Asan Medical Center
2016-2025
Ulsan College
2016-2025
Dankook University
1997-2024
Chonnam National University Hwasun Hospital
2024
Korea University Medical Center
2024
Yonsei University
2014-2020
Infinity HealthCare (United States)
2020
Yonsei University Health System
2020
Bundang Jesaeng Hospital
2020
Parkinson disease (PD), progressive supranuclear palsy (PSP), and multiple-system atrophy (MSA) are known to affect dopaminergic neurons of the brain stem striatum with different preferential involvement. Here we investigated differences in striatal subregional dopamine transporter loss PD, PSP, MSA assessed diagnostic value <sup>18</sup>F-fluorinated-<i>N</i>-3-fluoropropyl-2-β-carboxymethoxy-3-β-(4-iodophenyl)nortropane (<sup>18</sup>F-FP-CIT) PET differentiating PSP from PD....
Aprotic solvents are usually preferred for the SN2 reactions, because nucleophilicity and hence reactivity severely retarded by influence of partial positive charge protic solvents. In this work, we introduce a remarkable effect using tertiary alcohols as reaction medium nucleophilic fluorination with alkali metal fluorides. novel synthetic method, nonpolar tert-alcohol enhances fluoride ion dramatically in absence any kind catalyst, greatly increasing rate reducing formation byproducts...
OBJECTIVES This study was conducted to evaluate the clinical role of integrated positron emission and computed tomography (PET-CT) in patients with suspected potentially operable cholangiocarcinoma. METHODS Between October 2005 May 2007, 123 cholangiocarcinoma were enrolled this after diagnostic workup, including biliary dynamic (CT) magnetic resonance imaging/magnetic cholangiopancreatography (MRI/MRCP) (MR) angiography. Patients overt unresectable or gallbladder cancer diagnosed via...
The causes of rotator cuff tendon rupture are multifactorial and still unclear. Intrinsic extrinsic factors have been implicated as predisposing risk for rupture. Previous studies suggested a relationship between elevated serum lipid profiles ruptures, although not tears specifically.We therefore asked whether patients with were more likely to higher levels hypercholesterolemia than shoulder pain but without tears.We prospectively collected cholesterol on two age-matched populations...
Cerebral microbleeds (CMBs) are a neuroimaging marker of small vessel disease (SVD) with relevance for understanding mechanisms in cerebrovascular disease, cognitive impairment, and normal aging. It is hypothesized that lobar CMBs due to cerebral amyloid angiopathy (CAA) deep subcortical ischemic SVD. We tested this hypothesis using structural magnetic resonance imaging (MRI) markers SVD vivo patients impairment.We included 226 patients: 89 Alzheimer disease-related impairment (ADCI) 137...
This study was conducted to evaluate the clinical usefulness of PET/CT in differentiating autoimmune pancreatitis from pancreatic cancer.To differentiate cancer, we analyzed cases 17 patients with and atypical imaging findings who underwent integrated PET/CT. The on were compared those 151 cancer.Fluorine-18 FDG uptake by pancreas found all 82% (124/151) cancer. Diffuse significantly more frequent (53% vs 3%, p < 0.001). salivary glands kidneys seen only pancreatitis, former reaching...
Cerebrovascular disease (CVD) and Alzheimer are significant causes of cognitive impairment in the elderly. However, few studies have evaluated relationship between CVD β-amyloid burden living humans or their synergistic effects on cognition. Thus, there is a need for better understanding mild (MCI) before clinical deterioration begins.
To assess diagnostic accuracy of fluorine 18 ((18)F) fluorodeoxyglucose (FDG) combined positron emission tomography (PET) and computed (CT) in the detection occult primary tumors determination optimal care patients with cervical metastasis an unknown tumor (CUP) compared contrast material-enhanced CT alone or contrast-enhanced magnetic resonance (MR) imaging (CT/MR imaging).Institutional review board approval written informed consent were obtained. In total, 56 initially undetected after...
To assess the clinical usefulness of fluorine 18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed (CT) and CT/magnetic resonance (MR) imaging in detecting occult neck metastasis patients with head squamous cell carcinoma negative palpation findings.This prospective study was approved by institutional review board, written informed consent obtained from all enrolled patients. In total, 91 findings were assessed prospectively (18)F-FDG PET/CT CT/MR imaging....
To investigate whether the magnitude of presynaptic dopamine depletion is a risk factor for development levodopa-induced dyskinesia (LID) in Parkinson disease (PD) by quantitatively analyzing (18)F-FP-CIT PET data.This retrospective cohort study enrolled total 127 drug-naive de novo patients with PD who completed scanning at their initial evaluation. The visited our outpatient clinic every 3-6 months and had been followed minimum 2 years since beginning dopaminergic medication. predictive...
We tested our hypothesis that the white matter network might mediate effect of amyloid and small vessel disease (SVD) on cortical thickness and/or cognition.We prospectively recruited 232 patients with cognitive impairment. Amyloid was assessed using Pittsburgh compound B-PET. SVD quantified as hyperintensity volume lacune number. The regional connectivity measured nodal efficiency by applying graph theoretical analysis to diffusion tensor imaging data. performed neuropsychological tests.SVD...
To determine the effect of drusen and geographic atrophy (GA) in dry age-related macular degeneration on retinal sensitivity using an eye tracking scanning laser ophthalmoscope microperimetry.A total 44 eyes from 22 patients with 11 GA were imaged microperimetry (OPKO Health, Miami, FL). A custom pattern was used to evaluate a Goldmann III size target (108 μm retina). The perimetry 4-2 stepladder algorithm maximal sensitivity. Microperimetry optical coherence tomography performed...
We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular (CVD) pathologies on brain structural changes cognition.Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume white matter hyperintensities [WMH] number lacunae), (cortical thickness hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses utilized to assess these cognition.PiB ratio was associated with atrophy, which memory impairment. WMH frontal...
Background:Recent evidence suggests that combining individual imaging markers of cerebral small vessel disease (SVD) may more accurately reflect its overall burden and better correlate with clinical measures. Objective:We wished to establish the relevance total SVD score in a memory clinic population by investigating association cognitive performance, cortical atrophy, structural network measures, after adjusting for amyloid-β burden. Methods:We included 243 patients amnestic mild impairment...
See Cohen (doi:10.1093/aww183) for a scientific commentary on this article. Amyloid-β and cerebral small vessel disease are the two major causes of cognitive impairment in elderly. However, underlying mechanisms responsible precisely how amyloid-β affect remain unclear. We investigated effects lacunes downstream imaging markers including structural network cortical thickness, further analysing their relative impact trajectories. prospectively recruited pool 117 mild patients (45 amnestic...