A5033030009- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Health and Wellbeing Research
- Neurological Disorders and Treatments
- Ginkgo biloba and Cashew Applications
- Advanced MRI Techniques and Applications
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Frailty in Older Adults
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Telomeres, Telomerase, and Senescence
- EEG and Brain-Computer Interfaces
- Diverse Approaches in Healthcare and Education Studies
- Facial Nerve Paralysis Treatment and Research
- Cerebrospinal fluid and hydrocephalus
- Diet and metabolism studies
- MRI in cancer diagnosis
- Health, Environment, Cognitive Aging
Seoul St. Mary's Hospital
2024-2025
Catholic University of Korea
2006-2025
Konyang University Hospital
2015-2024
Konyang University
2015-2024
Chungnam National University
2021-2022
Korea Rural Economic Institute
2021
Chungnam National University Hospital
2019
University of Chicago
2006
Neurology, Inc
2006
Myosin light chain kinase (MLCK) is expressed as long and short isoforms from unique transcriptional start sites within a single gene. Tumor necrosis factor (TNF) augments intestinal epithelial MLCK expression, which critical to cytoskeletal regulation. We found that TNF increases mRNA transcription, both in human enterocytes vitro murine vivo.5'-RACE identified two novel exons, 1A 1B, encode alternative sites. Chromatin immunoprecipitation (ChIP) site-directed mutagenesis essential Sp1...
Background: Default mode network (DMN) functional connectivity is one of the neuroimaging candidate biomarkers Alzheimer disease. However, no studies have investigated DMN at different stages mild cognitive impairment (MCI). The aim this study was to investigate patterns and its breakdown among cognitively normal (CN), early MCI (EMCI), late (LMCI) subjects. Methods: Magnetic resonance imaging data neuropsychological test scores from 130 subjects (CN=43, EMCI=47, LMCI=40) were obtained...
Subjective memory impairment (SMI) is common among older adults. Increasing evidence suggests that SMI a risk factor for future cognitive decline, as well mild and dementia. Medial temporal lobe structures, including the hippocampus entorhinal cortex, are affected in early stages of Alzheimer's disease. The current study examined gray matter (GM) volume microstructural changes hippocampal regions individuals with SMI, compared elderly control participants without complaints.A total 45 (mean...
Abstract Background Neuropsychological tests (NPTs) are important tools for informing diagnoses of cognitive impairment (CI). However, interpreting NPTs requires specialists and is thus time-consuming. To streamline the application in clinical settings, we developed evaluated accuracy a machine learning algorithm using multi-center NPT data. Methods Multi-center data were obtained from 14,926 formal neuropsychological assessments (Seoul Screening Battery), which classified into normal...
Neurofilament light chain (NFL) level has been suggested as a blood-based biomarker for neurodegeneration in dementia. However, the association between baseline NFL levels and cognitive stage transition or cortical thickness is unclear. This study aimed to investigate whether are associated with mild impairment (MCI) cognitively unimpaired (CU) participants.This analyzed data on participants from independent validation cohort of Korea Brain Aging Study Early Diagnosis Prediction Alzheimer's...
Mild cognitive impairment (MCI) has been defined as a transitional state between normal aging and Alzheimer disease. Diffusion tensor imaging (DTI) can estimate the microstructural integrity of white matter tracts in MCI. We evaluated changes MCI patients with DTI. recruited 11 who met working criteria elderly controls. The mean diffusivity (MD) fractional anisotropy (FA) were measured 26 regions brain interest (ROIs) method. In patients, FA values significantly decreased hippocampus,...
We aimed to present the study design of an independent validation cohort from Korean Brain Aging Study for Early Diagnosis and Prediction Alzheimer’s disease (AD) (KBASE-V) investigate baseline characteristics participants according AD clinical spectrum. recruited 71 cognitively normal (CN) participants, 96 with subjective cognitive decline (SCD), 72 mild impairment (MCI), 56 dementia (ADD). The are followed three years. Consortium Establish a Registry scores was significantly different...
We investigated whether telomere length (TL) reflecting physical rather than chronological aging is associated with disease progression in the different cognitive stages of Alzheimer's (AD).Study participants included 89 subjects amyloid pathology (A+), determined through PET or cerebrospinal fluid analysis, including 26 cognitively unimpaired (CU A+) individuals, 28 mild impairment (MCI A+), and 35 AD dementia (ADD A+).As controls, 104 CU A-individuals were selected.The evaluated annually...
Dementia subtypes, including Alzheimer's dementia (AD), with Lewy bodies (DLB), and frontotemporal (FTD), pose diagnostic challenges. This review examines the effectiveness of
Dementia often accompanies behavioral and psychological symptoms of dementia (BPSD), including agitation, aggression, depression, psychosis, which impact patients' quality life caregiver burden. Effective management BPSD is essential to support patient well-being. This study presents evidence-based clinical practice guidelines for pharmacological treatments in dementia, focusing on antipsychotics, antidepressants, cognitive enhancers, other medications. guideline was developed by the Korean...
This clinical practice guideline provides evidence-based recommendations for treatment of dementia, focusing on cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists Alzheimer's disease (AD) other types dementia. Using the Population, Intervention, Comparison, Outcomes (PICO) framework, we developed key questions conducted systematic literature reviews. A multidisciplinary panel experts, organized by Korean Dementia Association, evaluated randomized controlled trials...
A combination of plasma phospho-tau (p-tau), amyloid beta (Aβ)-positron emission tomography (PET), brain magnetic resonance imaging, cognitive function tests, and other biomarkers might predict future decline. This study aimed to investigate the efficacy combining these in predicting stage transitions within 3 years.Among participants Korean Brain Aging Study for Early Diagnosis Prediction Alzheimer's Disease (KBASE-V) study, 49 mild impairment (MCI) 113 cognitively unimpaired (CU) with...
<h3>Objective:</h3> To determine whether acute risk factors (ARF) and chronic (CRF) contribute differently to the use of evidence-based treatments (EBT) for patients with coronary syndromes (ACS). <h3>Design:</h3> Data were collected through a prospective audit ACS. Management was analysed by presence myocardial comorbid at presentation. <h3>Setting:</h3> 39 hospitals across Australia. <h3>Patients:</h3> 2599 adults presenting <h3>Interventions:</h3> None. <h3>Main outcome measures:</h3> Use...
Background & Objective: Early-onset Alzheimer's disease (EOAD, onset age < 65 years) may differ from late-onset (LOAD) in terms of cognitive profiles and neuropsychiatric symptoms. There have been few studies for Korean EOA
Patients with amnestic mild cognitive impairment (aMCI) have an increased risk of dementia. However, conversion rate varies. Therefore, predicting the dementia in these patients is important.We aimed to develop a nomogram predict aMCI subjects using neuropsychological profiles.A total 338 from two hospital-based cohorts were used analysis. All classified into 1) verbal, visual, or both, 2) early late, and 3) single multiple-domain according modality, severity memory dysfunction, multiplicity...
Background and Objective: We investigated the influence of body mass index (BMI) status at baseline changes in BMI over a follow-up period on development dementia amnestic mild cognitive impairment (aMCI) patients. Methods: The longitudinal data 747 aMCI patients were used to investigate relationships among status, subsequent (median duration: 1.6 years, interquartile range: 1.0–2.3 years), risk progression probable Alzheimer’s disease (pADD). classified into underweight, normal weight,...
Background: Balance impairments are common in patients with Alzheimer’s disease (AD) dementia. Objective: We sought to determine the stage along AD spectrum during which balance appear and identify factors associated a decline function. Methods: Our cross-sectional study included 295 participants; 71 were cognitively normal (CN), 96 reported subjective cognitive (SCD), 72 had amnestic mild impairment (MCI), 56 The mobility function was assessed using Timed Up Go test (TUG) One-Leg Standing...
Subjective memory impairment (SMI) is now increasingly recognized as a risk factor of progression to dementia.This study investigated gray and white matter changes in the brains SMI patients compared with normal controls mild cognitive (MCI) patients.We recruited 28 controls, subjects SMI, 29 MCI aged 60 or older.We analyzed using voxel-based morphometry (VBM), hippocampal volumetry regions interest diffusion tensor imaging (DTI).DTI parameters corpus callosum cingulum showed more those they...