A5071757863- Dental Implant Techniques and Outcomes
- Lung Cancer Treatments and Mutations
- Bone Tissue Engineering Materials
- Aluminum Alloy Microstructure Properties
- Periodontal Regeneration and Treatments
- Aluminum Alloys Composites Properties
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Healthcare and Venom Research
- Lung Cancer Research Studies
- Signaling Pathways in Disease
- Colorectal Cancer Treatments and Studies
- Inflammatory mediators and NSAID effects
- Metallurgy and Material Forming
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Ovarian function and disorders
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- 3D IC and TSV technologies
- Ginseng Biological Effects and Applications
- Salivary Gland Tumors Diagnosis and Treatment
Chosun University
2016-2025
Royal North Shore Hospital
2024
Chonnam National University
2012-2024
Chonnam National University Hospital
2000-2024
Chosun University Hospital
2003-2024
Kyung Hee University Medical Center
2024
St. Vincent's Hospital
2020-2023
Sungkyunkwan University
2021
New Generation University College
2021
Seoul National University
2021
Abstract Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has a response rate of 10% to 20% in refractory non–small cell lung carcinoma. Although female gender, adenocarcinoma, and never having smoked are possible markers favorable response, mutations the EGFR gene have also been reported be highly significant predictors response. Seventy patients with relapsed carcinoma were enrolled Expanded Access Program. After drug became available commercially, 28 more...
Endoplasmic reticulum (ER) stress causes cell survival or death, which is dependent on the type of and stimulus. Capsaicin (8-methyl-<i>N</i>-vanillyl-6-nonenamide) its analog, dihydrocapsaicin (DHC), induced caspase-3-independent/-dependent signaling pathways in WI38 lung epithelial fibroblast cells. Here, we describe molecular mechanisms by both chemicals. Exposure to capsaicin DHC caused induction p53, p21, G<sub>0</sub>/G<sub>1</sub> arrest. massive cellular vacuolization dilation ER...
BACKGROUNDThe aim of study was to determine the relative frequency malignant lymphoma according World Health Organization (WHO) classification in Korea.METHODSA total 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site involvement immunophenotypes obtained.RESULTSThe non-Hodgkin (NHL) Hodgkin (HL) 95.4% 4.6%, respectively. B-cell lymphomas accounted for 77.6% all NHL, while T/natural killer (T/NK)-cell...
Aberrant expression of apurinic-apyrimidinic endonuclease–1 (APEX1) has been reported in numerous human solid tumors and is positively correlated with cancer progression; however, the role APEX1 tumor progression poorly defined. Here, we show that contributes to aggressive colon behavior functions as an upstream activator Jagged1/Notch signaling pathway. overexpression or knockdown cell lines induced profound changes malignant properties such proliferation, anchorage-independent growth,...
Despite the worldwide effect of coronavirus disease 2019 (COVID-19) pandemic, underlying mechanisms fatal viral pneumonia remain elusive. Here, we show that critical COVID-19 is associated with enhanced eosinophil-mediated inflammation when compared to non-critical cases. In addition, confirm increased T helper (Th)2-biased adaptive immune responses, accompanying overt complement activation, in group. Moreover, antibody responses and activation are pathogenesis as evidenced by formation...
In 824 patients who underwent directional vacuum-assisted biopsies (DVABs) of breast microcalcifications, 61 (7.4%) showed atypical ductal hyperplasia (ADH). The 42 subsequently excision were the subjects this study. Cases evaluated for mammographic characteristics lesion, percentage lesion removed according to mammography, and histologic findings (including number large ducts and/or terminal duct–lobular units involved with ADH) in DVAB specimens. Pathologic surgical specimens area biopsy...
Abstract Hepatocellular carcinoma (HCC) is resistant to chemotherapy. Recently, however, several oxaliplatin‐based combinatorial treatments have shown a promising anti‐tumor activity in patients with HCC. Presently, we demonstrate that oxaliplatin triggers necrosis more than apoptosis HepG2, SK‐Hep1, SNU‐423 and Hep3B HCC cells, while mainly inducing HCT116 HT29 colon cancer cells. Interestingly, ursodeoxycholic acid (UDCA), less hydrophobic bile can suppress carcinogenesis, shifted...
Although capsaicin, a pungent component of red pepper, is known to induce apoptosis in several types cancer cells, the mechanisms underlying capsaicin-induced cytotoxicity are unclear. Here, we showed that dihydrocapsaicin (DHC), an analog potential inducer autophagy. DHC was more cytotoxic than capsaicin HCT116, MCF-7 and WI38 cell lines. Capsaicin did not affect on sub-G1apoptotic peak, but induced G0/G1 arrest HCT116 cells. caused artificial autophagosome marker GFP-LC3 redistribute...
The purpose of this study was to compare the predictability new bone formation using an autologous concentrated growth factor (CGF) graft alone and platelet alone.Four bony defects 8 mm were formed, 3.7- × 10-mm implants placed in right femur. platelet-rich fibrin (PRF), CGF, synthetic grafted defect area. Enzyme linked immunosorbent assay quantitative analysis microscopic fibrinogen structure performed.At 4 weeks, comparisons each experimental group showed a significant difference between...
The most common therapy for estrogen receptor-positive breast cancer is antihormone therapy, such as tamoxifen. However, acquisition of resistance to tamoxifen in one third patients presents a serious clinical problem. Polo-like kinase 1 (Plk1) key oncogenic regulator completion G2-M phase the cell cycle. We assessed Plk1 expression five chemoresistant types and found that its downstream phosphatase Cdc25c were selectively overexpressed tamoxifen-resistant MCF-7 (TAMR-MCF-7) cells. Real-time...
Abstract Tamoxifen (TAM) is the standard anti-hormonal therapy for estrogen receptor-positive breast cancer. However, long-term TAM can make acquisition of resistance and there are still no solutions to treat TAM-resistant In this study, we found that protein mRNA expression P2X purinoreceptor 7 (P2X7) was higher in tamoxifen resistant MCF-7 (TAMR-MCF-7) cells than control cells. P2X7 inhibition potently inhibited migration TAMR-MCF-7 liver metastasis burden spleen-liver experiment....
The acidic tumor environment has emerged as a crucial factor influencing the metastatic potential of cancer. We investigated effect an on acquisition properties in MCF7 breast cancer cells and explored inhibitory effects gallic acid. Prolonged exposure to culture conditions (over 12 weeks at pH 6.4) induced migratory invasive cells, accompanied by increased expression Matrix Metalloproteinase 2 9 (MMP2 MMP9, respectively), together with alterations E-cadherin, vimentin,...
Inherited mutation in breast cancer susceptibility gene 1 (BRCA1) is strongly associated with mammary tumors that exhibit triple-negative characteristics, are insensitive to endocrine-targeted therapies, and show basal-like properties, including aggressive phenotypes [1, 2]. It has been reported the average cumulative risk of for BRCA1 carriers by age 70 years 57% (95% confidence interval [CI]: 47%-66%) [3]. Despite high incidence characteristics BRCA1-associated cancer, few substantial...