A5101932290- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Trigeminal Neuralgia and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Polysaccharides and Plant Cell Walls
- Congenital Anomalies and Fetal Surgery
- Macrophage Migration Inhibitory Factor
- Cell Adhesion Molecules Research
- Radiation Detection and Scintillator Technologies
- Axon Guidance and Neuronal Signaling
- Cellular Mechanics and Interactions
- Names, Identity, and Discrimination Research
- Animal Genetics and Reproduction
- Complement system in diseases
- Acupuncture Treatment Research Studies
- Regional Development and Environment
- Microfluidic and Bio-sensing Technologies
- EEG and Brain-Computer Interfaces
- Pectus Deformity Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Apelin-related biomedical research
Eulji University
2018-2024
Daejeon University
2014-2016
Gachon University Gil Medical Center
2016
Kyungpook National University
2006-2012
Hallym University
2006
Chungnam National University
2000-2006
Institute of High Energy Physics
1993
Despite the worldwide effect of coronavirus disease 2019 (COVID-19) pandemic, underlying mechanisms fatal viral pneumonia remain elusive. Here, we show that critical COVID-19 is associated with enhanced eosinophil-mediated inflammation when compared to non-critical cases. In addition, confirm increased T helper (Th)2-biased adaptive immune responses, accompanying overt complement activation, in group. Moreover, antibody responses and activation are pathogenesis as evidenced by formation...
We have previously reported a novel method for producing chronic nociceptive behavior in rats following compression of the trigeminal ganglion. In present study, we further studied role demyelination development prolonged territory. For this purpose, lysophosphatidic acid (LPA) was injected into ganglia male Sprague-Dawley weighing between 250 and 260 g. Under pentobarbital sodium anesthesia, were mounted onto stereotaxic frame 3 microL LPA (1 nmol) solution ganglion to produce...
Background: We investigated the differential regulation of p-p38 MAPK or p-NF- κB in male Sprague-Dawley rats with inferior alveolar nerve injury resulting from mal-positioned dental implants. For this purpose, we characterized temporal expression medullary dorsal horn and examined changes nociceptive behavior after a blockade pathways trigeminal neuropathic pain. Results: Under anesthesia, left lower second molar was extracted replaced mini implant to intentionally injure nerve. Western...
ABSTRACT The present study is the first demonstration of prolonged nociceptive behavior in trigeminal region following compression ganglion rats. Experiments were carried out on male Sprague–Dawley rats mounted onto a stereotaxic frame under pentobarbital sodium anesthesia. For ganglion, 4% agar solution (8μl) was injected into through stainless steel injector (24 gauge), which extended 2mm beyond end guide cannula (21 gauge). Following injection, and removed. In control group, sham operated...
The analgesic effects of dexamethasone on neuropathic pain have been controversial. present study investigated the mechanical allodynia in rats with mal-positioned dental implants. Under anesthesia, left mandibular second molar was extracted and replaced by a miniature implant to injure inferior alveolar nerve. Nociceptive behavior examined each designated day after surgery. Mal-positioned implants significantly decreased air-puff thresholds both ipsilateral contralateral injury site....
// Yun Hee Kang 1 , Seung Ro Han 2 Jong-Tae Kim Seon-Jin Lee Young Il Yeom Jeong-Ki Min Chul-Ho Jae Wha Suk Ran Yoon Do-Young 3 Kwan Soo Hong 4 Geum-Sook Hwang Cheol 5 Young-Ha 6 and Gu Medical Genomics Research Center, Korea Institute of Bioscience Biotechnology, Daejeon, Korea, Department Biological Science, Daejeon University, BIMC, Konkuk Seoul, Seoul Basic Science Institute, Surgery, Samsung Sungkyunkwan University School Medicine, Infection Biology, Chungnam National Correspondence:...
The demyelinating diseases of the central nervous system involve myelin abnormalities, oligodendrocyte damage, and consequent glia activation. Neurotoxicant cuprizone (CPZ) was used to establish a mouse model demyelination. However, effects CPZ on microRNA (miRNA) expression behavior have not been clearly reported. We analyzed mice administered diet containing 0.2% for 6 weeks, followed by weeks recovery. Rotarod analysis demonstrated that treated group had poorer motor coordination than...
There is increasing evidence that the complement system activated in various cancer tissues. Besides being involved innate immunity against pathogens, also participates inflammation and modulation of tumor microenvironment. Recent studies suggest activation promotes progression ways. Among some cell lines, we found human bone osteosarcoma epithelial cells (U2-OS) can activate alternative pathway by pooled normal serum. Interestingly, U2-OS showed less expression regulatory proteins, compared...
We reported previously that tescalcin (TESC) levels were higher in tissue and serum from colorectal cancer (CRC) patients suggested TESC was a potential oncotarget CRC. The aim of this study to investigate the function CRC invasion metastatic potential. expression knocked down cells using small interfering RNA (siRNA). siRNA reduced cell migration by inhibiting matrix metalloprotease (MMP) epithelial-mesenchymal transition (EMT) pathway. RT-PCR Western blot analysis showed induced...
Extracellular vesicles (EVs) derived from urine are promising tools for the diagnosis of urogenital cancers. Urinary EVs (uEVs) considered potential biomarkers bladder cancer (BC) because is in direct contact with BC tumor microenvironment and thus reflects current state disease. However, challenges associated effective isolation analysis uEVs complicate clinical detection uEV-associated protein biomarkers. Herein, we identified uEV-derived alpha-2-macroglobulin (a2M) as a novel diagnostic...
Background: We investigated the role of central NMDA receptor NR2 subunits in modulation nociceptive behavior and p-p38 MAPK expression a rat model with compression trigeminal nerve root. To address this possibility, changes air-puff thresholds pin-prick scores were determined following an intracisternal administration subunit antagonists. also examined effects antagonists on expression. Results: Experiments carried out using male Sprague-Dawley rats weighing (200-230 g). Compression root...
The present study investigated the role of peripheral opioid receptors in mustard oil-induced nociceptive behavior and inflammation masseter muscles lightly anesthetized rats. Experiments were carried out on male Sprague-Dawley rats weighing between 300 400 g. After initial anesthesia with sodium pentobarbital (40 mg/kg, i.p.), one femoral vein was cannulated connected to an infusion pump for intravenous pentobarbital. rate adjusted provide a constant level anesthesia. Mustard oil (MO, 30...
Abstract Nogo receptor (NgR) has been shown to inhibit the migration and invasion of human glioma cells. However, little is known regarding regulatory mechanisms NgR in glioblastoma multiforme (GBM). In this study, we propose a novel mechanism that regulates maturation process through an interaction with vimentin. The inhibition TGFβ1 activity by LY2109761 attenuated migration/invasion GBM cells upregulating cell-surface NgR. Conversely, treatment suppressed maturation. We showed vimentin...
Group I mGluRs (mGluR1 and 5) pre- and/or postsynaptically regulate synaptic transmission at glutamatergic synapses. By recording spontaneous EPSCs (sEPSCs) in the spinal trigeminal subnucleus oralis (Vo), we here investigated regulation of through activation group mGluRs. Bath-applied DHPG (10 μM/5 min), activating mGluRs, increased sEPSCs both frequency amplitude; particularly, amplitude was long-lasting. The DHPG-induced increases sEPSC were not NMDA receptor-dependent. increase sEPSCs,...
Magnetic particle imaging (MPI) is an emerging radiation-free, non-invasive three-dimensional tomographic technology that can visualize the concentrations of superparamagnetic iron oxide nanoparticles (SPIONs). To verify applicability previously proposed point-of-care testing MPI (PoCT-MPI) in medical diagnosis and therapeutics, we imaged SPIONs animal tumor models.CT26 or MC38 mouse colon carcinoma cells (2 × 106 cells) were subcutaneously injected into right flank BALB/c mice. either...