A5065019731- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Nosocomial Infections in ICU
- Orthopedic Infections and Treatments
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Tuberculosis
- Clostridium difficile and Clostridium perfringens research
- Infective Endocarditis Diagnosis and Management
- Urinary Tract Infections Management
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Infections and bacterial resistance
- Tuberculosis Research and Epidemiology
- Respiratory Support and Mechanisms
- Microscopic Colitis
- Streptococcal Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Bacterial Infections and Vaccines
- Escherichia coli research studies
- Antibiotics Pharmacokinetics and Efficacy
Chungnam National University Hospital
2011-2023
Chungnam National University
2013-2023
Samsung Medical Center
2007-2012
Sungkyunkwan University
2007-2012
Konkuk University
2005
Abstract Despite the ongoing spread of MERS, there is limited knowledge factors affecting its severity and outcomes. We analyzed clinical data specimens from fourteen MERS patients treated in a hospital who collectively represent wide spectrum disease severity, ranging mild febrile illness to fatal pneumonia, classified into four groups based on mortality. Comparative kinetic analyses revealed that high viral loads, weak antibody responses, lymphopenia accompanying thrombocytopenia were...
Observational studies of the ongoing coronavirus disease 2019 (COVID-19) outbreak suggest that a 'cytokine storm' is involved in pathogenesis severe illness. However, molecular mechanisms underlying altered pathological inflammation COVID-19 are largely unknown. We report here toll-like receptor (TLR) 4-mediated inflammatory signaling molecules upregulated peripheral blood mononuclear cells (PBMCs) from patients, compared with healthy controls (HC).
Background: From May to July 2015, the Republic of Korea experienced largest outbreak Middle East respiratory syndrome (MERS) outside Arabian Peninsula.A total 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as September 30th, 2015.Materials and Methods: We obtained information patients who were confirmed have MERS-CoV infection.MERS-CoV was using real-time reverse-transcriptase polymerase chain reaction assay. Results:The median age 55 years...
Autophagy is an important antimicrobial effector process that defends against Mycobacterium tuberculosis (Mtb), the human pathogen causing (TB). MicroRNAs (miRNAs), endogenous noncoding RNAs, are involved in various biological functions and act as post-transcriptional regulators to target mRNAs. The by which miRNAs affect antibacterial autophagy host defense mechanisms Mtb infections monocytes macrophages largely uncharacterized. In this study, we show significantly induces expression of...
ABSTRACT The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe infection with high mortality rate (~35%). MERS-CoV has been global threat due to continuous outbreaks in the Arabian peninsula and international spread by infected travelers since 2012. From May July 2015, large outbreak initiated an traveler from swept South Korea resulted 186 confirmed cases 38 deaths (case fatality rate, 20.4%). Here, we show rapid emergence of mutant reduced affinity...
De-escalation therapy is a strategy currently used for the management of nosocomial pneumonia. In this study, we evaluated clinical outcomes and risk factors related to de-escalation in patients with intensive care unit (ICU)-acquired pneumonia.This was retrospective observational cohort study ICU who developed pneumonia more than 48 hours after admission at Samsung Medical Center from September 2004 December 2007.The 137 comprised 44 (32.1%) received 93 non-de-escalation group. The group...
There are no available studies on the duration and risk factors of vancomycin-resistant enterococci (VRE) carriage after hospital discharge. In this study we investigated colonization with VRE for prolonged in outpatient clinic discharge from hospital.The took place January 2008 to September 2009. Patients were included if they identified as persistent carriers by follow-up rectal swab or stool cultures setting, without clearance VRE. The probability culture positivity was analyzed date. Cox...
Clostridioides difficile causes healthcare-related diarrhoea in high-income countries. Highly resistant spores persist healthcare facilities, primarily infecting patients who have recently received antimicrobials. C. infection (CDI) has been studied detail North America and Europe; however, the epidemiology of CDI elsewhere, including Asia-Pacific region, is largely unknown. A survey was performed 13 Epidemiological data on 600 cases were collected molecular typing undertaken 414 isolates....
Despite the worldwide effect of coronavirus disease 2019 (COVID-19) pandemic, underlying mechanisms fatal viral pneumonia remain elusive. Here, we show that critical COVID-19 is associated with enhanced eosinophil-mediated inflammation when compared to non-critical cases. In addition, confirm increased T helper (Th)2-biased adaptive immune responses, accompanying overt complement activation, in group. Moreover, antibody responses and activation are pathogenesis as evidenced by formation...
Background: A Middle East Respiratory Syndrome coronavirus (MERS-CoV) outbreak in South Korea 2015 started by a single imported case and was amplified intra-and inter-hospital transmission.We describe two hospital outbreaks of MERS-CoV infection Daejeon caused patient who infected the first Korean MERS. Materials Methods:Demographic clinical information involving MERS cases cluster were retrospectively collected potential contacts exposures assessed.The incubation periods serial intervals...
Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.This disease, which quickly spreading worldwide, has high potential for infection and causes rapid progression of lung lesions, resulting in a mortality rate.This study aimed to investigate the effects SARS-CoV-2 on renal function patients with COVID-19.Methods: From February 21 April 24, 2020, 66 diagnosed COVID-19 at Chungnam National University Hospital were...
We estimated the nationwide burden of nosocomial S. aureus bloodstream infection (SA-BSI), a major cause infection, in South Korea. To evaluate incidence SA-BSI, cases SA-BSI were prospectively collected from 22 hospitals with over 500 beds 4?months. Data on patient-days obtained national health insurance database containing claims data for all healthcare facilities The additional cost was through matched case?control study. economic calculated sum medical costs, costs caregiving and loss...
Clostridium ( Clostridioides ) difficile causes toxin-mediated diarrhea and pseudomembranous colitis, primarily among hospital inpatients. Outbreaks of C. infection (CDI) have been caused by strains with acquired antimicrobial resistance, particularly fluoroquinolone including ribotype (RT) 027 in North America Europe RT 017, the most common strain Asia. Despite being cause hospital-acquired high-income countries, frequent misuse antimicrobials Asia, little is known about CDI Asia-Pacific region.
Antimicrobial prescriptions for serious chronic or acute illness nearing its end stages raise concerns about the potential futile use, adverse events, increased multidrug-resistant organisms, and significant patient social cost burdens. This study investigated nationwide situation of how antibiotics are prescribed to patients during last 14 days life guide future actions.This multicenter retrospective cohort was conducted at 13 hospitals in South Korea from November 1 December 31, 2018. All...
Panton-Valentine leukocidin (PVL)-positive USA300 clone has been the most successful community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) spreading in North America. In contrast, PVL-negative ST72-CA-MRSA predominant Korea, and there no report of infections by strain except only one case perianal infection. Here, we describe first pneumonia caused following pandemic influenza A (H1N1) Korea. 50-year-old man was admitted with fever cough chest radiograph showed pneumonic...
A Case ReportWe report a case of spontaneous bacterial peritonitis from Ochrobactrum anthropi.O. anthropi is recognized as an emerging pathogen in immunocompromised patients.In contrast to most previously described cases, the patient reported here had no indwelling catheter.To our knowledge, O. has been medical literature until now.
Background/Aims We evaluated the clinical features of ciprofloxacin-resistant Proteus mirabilis bacteremia and risk factors for ciprofloxacin resistance. Methods From October 2000 to July 2009, 37 patients with clinically significant P. were identified data from ciprofloxacin-susceptible compared. Results The most common underlying diseases neurologic disease (37.8%) solid tumors (29.7%). site infection was urinary tract (35.1%). Ten (27.0%) infected isolates, univariate analysis revealed a...
Mortality of Community-Acquired Pneumonia in Korea:Assessed with the Severity Index and CURB-65 ScoreThe pneumonia severity index (PSI) are widely used tools for prediction community-acquired (CAP).This study was conducted to evaluate validation scoring system including PSI scores Korean CAP patients.In prospective cohort (participated by 14 hospitals Korea from January 2009 September 2011), 883 patients aged over 18 yr were studied.The 30-day mortalities all calculated their classes CURB...
Despite a clear association of patient's age with COVID-19 severity, there has been conflicting data on the viral load disease severity. Here, we investigated dynamics and severity using set respiratory specimens longitudinally collected (mean: 4.8 times/patient) from 64 patients broad distribution clinical during acute phase. Higher burden was positively associated inflammatory responses, as assessed by IL-6, C-reactive protein, lactate dehydrogenase levels in patients' plasma same day,...